PTH nce - raws li evidenced los ntawm tsom xam?

Parathyroid hormone (txwv tsis pub hu ua parathyroid lawm, parathyrin) - ib yam tshuaj ua los ntawm cov parathyroid cov ntaub so ntswg (parathyroid) qog, uas muaj nyob rau ntawm lub anterolateral sab ntawm lub caj dab. Lawv yog cov qab lub qog caj pas, uas yog zoo nyob ib sab mus rau lub rear nto thereof thiab lub qis ib feem ntawm ob nws qhia. Parathyroid hormone nyob rau hauv lawv cov tshuaj xwm yog ib tug complex protein tshuaj - polypeptide amino acid derivatives.

Nws lub ntsiab muaj nuj nqi yog yuav tsum koom thiab kev cai ntawm calcium thiab phosphorus metabolism hauv lub cev. Cov ntsiab lus ntawm calcium nyob rau hauv cov ntshav thiab cov pa ntawm parathyroid lawm yog ncaj qha nyob ntawm txhua lwm yam. Cov tshuaj yuav ua rau kom cov calcium uas concentration ntawm ua yeeb yam nyob rau hauv cov pob txha ntaub so ntswg, lub raum thiab hnyuv ib ntsuj av. Cov pob txha parathyrin tsub kom logoff dissolving lub mineral ib feem los ntawm stimulating synthesis ntawm tej enzymes uas yog lub luag hauj lwm rau lub neej puas ntawm cov pob txha ntaub ntawv. Pob Txha cov ntaub so ntswg yog raug nyob rau hauv tus ntawm PTH resorption thiab calcium ions nyob rau hauv cov ntshav. Ua ke nrog calcium pauv paratgormot pab tswj cov theem ntawm phosphate nyob rau hauv lub cev. Txo cov kev siv ntawm cov thawj lom txheej txheem, nws amplifies lub thib ob txaus. Ntxiv mus, lub hormone yog muab kev koom tes nyob rau hauv pab tau synthesis ntawm calcitriol nyob rau hauv cov hnyuv, pab calcium reabsorption. Parathyroid hormone yuav siv sij hawm ib tug indirect ib feem nyob rau hauv cov kev cai ntawm cov kev ua ub ntawm tag nrho cov calcium-dependent enzymes katalirizuemye lawv cov tshuaj tiv thaiv. Nyob rau hauv nws lub hwj kuj tau txais cov ntshav coagulation system.

Yog hais tias PTH yog tsa, ces tsim mob loj heev endocrine kab mob txuam nrog cov pob txha sam xeeb txhaum - hyperparathyroidism, thiab txha. Cov tshwm sim ntawm xws physiological defect sharply txo nyob rau hauv cov ntshav calcium ntau ntau, uas ua rau yus muaj zog neuromuscular excitability. Comorbidities nyob rau hauv cov ntaub ntawv no yuav pab tau siab alkali cov ntsiab lus nyob rau hauv lub cev thiab cov kev loj hlob ntawm lub raum tsis ua hauj lwm. Los ntawm kev txo cov ntsiab lus ntawm calcium nyob rau hauv lens cataract ob lub qhov muag tshwm sim.

Theem ntawm cov hormone ntawm lub parathyroid qog nyob rau hauv cov ntshav yuav raug ib tug circadian atherosclerosis. Lub basal theem yog teem rau ntawm txog 8 teev sawv ntxov, thaum nyob rau hauv lub 14-16 teev ntawm lub hnub, thaum ib tug txiv neej yog ntawm lub ncov ntawm kev ua si, parathyroid hormone nce. cov ntshav mus kuaj yog nqa tawm los ntawm tus xov tooj ntawm parathyrin immunohemilyuminestsentsii. Nws yuav tsum ua ib qho kev npliag plab, nrog ib hnub los yog ob tug ua ntej cov ntshav zauv tshem tawm cawv kom tsawg thiab hnyav ib ce rau ob peb teev ua ntej sai, tsis haus luam yeeb.

Nyob rau tsom xam ntawm parathyroid lawm yog tshuaj tsuas yog thaum ib tug neeg mob yog xav tias lub hav zoov ntawm cov kab mob xws li hyper- thiab gipokaltsimiya, urolithiasis thiab neurofibromatosis. Tsis tas li ntawd indications rau kev tsom xam lub hom phiaj yuav muaj xws li: txha psevdoperelomy ntev cov pob txha, tej physiological hloov osteosclerosis pob txha los yog vertebral lub cev thiab xav tias ntau yam endocrine neoplasia hom 1 thiab hom 2 (TXIV NEEJ 1.2). Nyob rau parathormone tus nqi rau ib tug neeg laus yog suav tias yog 9,5-75 pg / ml. Qhov no siv tau rau ob leeg cov txiv neej thiab cov poj niam ntawm lub tsev me nyuam muaj hnub nyoog. Yog paub hais tias cov PTH yog tsa, muaj yog txhua txhua yog vim li cas rau pov plob hais tias tus neeg mob muaj cov thawj, theem nrab, tertiary hyperparathyroidism, pseudohypoparathyreosis los yog Zollinger-Ellison syndrome.

Nyob rau hauv lub neej coj thawj hyperparathyroidism hyperplasia ntawm lub parathyroid caj pas, mob cancer ntawm lub prostate cov ntaub so ntswg thiab endocrine neoplasia ob hom. Co. theem nrab hyperparathyroidism muaj xws li mob raum insufficiency, hypervitaminosis D, ulcerative mob plab, rickets, Crohn tus kab mob. Yog hais tias PTH yog tsa, ces tus tsom xam yog feem ntau yog ua nyob rau hauv nrog lub ntsiab txhais ntawm lub theem ntawm calcium nyob rau hauv cov ntshav thiab nyob rau hauv lub neej yav tom ntej cov kev sib piv ntawm ob ntsuas thiab qhia dependencies.