"Pentoxifylline": analogues, cov lus qhia rau kev siv, tiag tiag nqi

Cov tshuaj yuav tau muab hloov los ntawm "Pentoxifylline?" Ib tug analogue ntawm cov tshuaj yuav tsum nyob rau hauv qhov tsab xov xwm ntaub ntawv. Los ntawm nws koj yuav kawm tau dab tsi yog meant hais tias medicament ntaub ntawv nyob rau hauv uas nws yog muag, yuav ua li cas nws yuav tsum tau siv, thiab hais txog.

Muaj pes tsawg leeg, zoo lawm, ntim

Nyob rau hauv dab tsi daim ntawv no yog muag yeeb tshuaj "Pentoxifylline?" Cov lus qhia rau kev siv (analogues ntawm cov tshuaj no muaj peev xwm yuav nrhiav tau nyob rau hauv tej lub tsev muag tshuaj) ntawd hais tias cov tshuaj yog muaj nyob rau hauv ntau yam ntaub ntawv, namely:

• Nyob rau hauv cov ntsiav tshuaj (400 thiab 100 mg) yog coated liab. Nyob rau hauv ib thawv tej zaum yuav muaj 60 los yog 20 daim.
• Lub pellets (400 thiab 100 mg). Lub suab pob ntawm cov duab los qhia tej zaum yuav 60 los sis 20 daim.
• Nyob rau hauv cov ntsiav tshuaj, lub caij nyoog kev txiav txim (600 thiab 400 mg) yog coated thiab enteric coated muaj ib tug kab rau division. Lub ntim thawv feem ntau muaj 50 daim.
• Lub vials nrog cov tshuaj cov kev txhaj tshuaj. Muaj pes tsawg leeg ntawm no formulation muaj xws li pentoxifylline thiab sodium tshuaj dawb thiab dej.

pharmacological nta

Yuav ua li cas cov khoom puas cov tshuaj "Pentoxifylline?" Analogue ntawm no txhais tau tias muaj cov tib yam ntxwv raws li hais medicament ib leeg. Nws yog ib tug tshiab pharmacological pab pawg neeg hemorheological nyiaj. Nws yog tau los lub plasticity ntawm cov ntshav liab thiab txo lawv deformation. Qhov no yuav tsub lub permeability ntawm cov hlab ntsha, uas muaj ib tug nqiam lumen.

Cov thaj chaw ntawm cov tshuaj ua rau paub microcirculation, zoo ntxim rau cov ntaub so ntswg hypoxia.

Yuav ua li cas puas "Pentoxifylline?" Analogues ntawm ntshuam thiab Lavxias teb sab muaj tib lub kho nyhuv li hais tias ntawm cov nyiaj rau nws tus kheej. Tom qab siv cov yeeb tshuaj, nws thiaj li aggregation ntawm erythrocytes uas tom qab tau yooj yim ua rau kom ntshav txaus rau nruab nrog cev thiab txeem mus rau hauv lub extravascular kev taw qhia.

Peb tsis tau hais tias qhov suav hais tias cov tshuaj thiaj li ntshav viscosity, yog li yeej txhawb platelet disaggregation. Raws li ib tug tshwm sim ntawm cov teebmeem ntawm cov tshuaj yog nce feeb thiab mob stroke volume, tab sis nws tsis hloov lub plawv dhia nuj nqis.

Yog li, mob ntsws expansion txog ntsha pab txoj kev O ₂ cov ntsiab lus ntawm cov ntshav, thiab cov expansion ntawm lub coronary hlab ntsha mus kom O ₂ tus me nyuam mus rau lub myocardium.

Saib formulation muaj peev xwm zuj zus lub suab nrov ntawm ua pa nqaij thiab diaphragm. Nyob rau hauv nws cov cawv tsub kom tus nqi ntawm cov ntshav uas ntws los ntawm collaterals, raws li zoo raws li kho kom zoo ntshav txaus nyob rau hauv lawv.

Yuav ua li cas lwm nta lub tshuaj muaj "Pentoxifylline?" Analogue ntawm cov tshuaj no thiab cov tshuaj nws tus kheej kom tus concentration ntawm ATP nyob rau hauv lub hlwb thiab tseem ua kom cov ntshav mov rau cov puas cheeb tsam (e.g., nyob rau hauv ischemic stroke).

Nws yuav tsum tau muab sau tseg tias hais tias cov tshuaj muaj ib tug zoo feem nyob rau hauv lub hauv paus poob siab system thiab nws cov lag luam. Nyob rau hauv qhov txhab ntawm peripheral hlab ntsha siv qhov no txhais tau ua rau kom nyob rau hauv taug kev mus, xws li nrog xws li cov kab mob li obliterative endarteritis.

pharmacokinetic tsis

tshuaj "Pentoxifylline" ntev npaum li cas twv? Cov lus qhia rau kev siv (analogues cov tshuaj no uas tau teev tseg hauv qab no) qhia rau peb hais tias cov tshuaj no muaj zoo heev tob tob hwj chim, xws li los ntawm cov ntshav-hlwb barrier.

Lub ib nrab-lub neej ntawm cov tshuaj thaum muab intravenously yog 30 feeb. Thaum tau txais cov tshuaj hauv nws yog kiag li absorbed los ntawm cov hnyuv ib ntsuj av.

Medicament hloov nyob rau hauv lub siab, nyob qhov twg nws cov ntaub ntawv metabolites theobromine. Qhov siab tshaj plaws ntshav concentration ntawm cov tshuaj no yog tiav tsis pub dhau 4 teev tom qab daim ntawv thov. Txawm li cas los, nws tseem nyob rau ntawm lub tshuaj ntau ntau rau txog ib hnub twg.

Tso tawm kom pom medicament nyob rau hauv lub ob lub raum (kwv yees li 95%). hnyuv los ntawm cov tshuaj tawm me ntsis.

Thaum lub fairer poj niam txiv uas pub niam mis, cov tshuaj yuav tsum tau tso tawm nrog rau cov mis nyuj. Nws yuav tsum tau muab sau tseg tias tshem tawm ntawm cov tshuaj tub ceevxwm nyob rau hauv cov neeg mob uas muaj mob loj mob raum, siab thiab nyob rau hauv cov neeg laus.

Indications rau kev siv

Vim li cas lub hom phiaj rau tus neeg mob yuav raug muab tso rau cov tshuaj "Pentoxifylline?" Analogs thiab tshuaj hloov muaj tib lub indications.

Tam sim no, xws ib tug zoo tshuaj no yog siv los kho ntau yam kab mob. Ntawm no lawv yog tam sim no:

• cerebrovascular tsis muaj peev xwm;
• urolithiasis;
• arteriosclerotic encephalopathy;
• ischemic stroke;
• ntshav qab zib nefroangiopatiya;
• tawg;
• obstructive ntsws;
• bronchial hawb pob;
• peripheral plawv mob ;
• encephalopathy;
• algomenorrhea;
• sepsis;
• cholecystitis;
• plab hnyuv dyskinesia ;
• pilorospazm;
• tus nqaij spasm;
• post-trombophlebitic syndrome;
• dysmenorrhea;
• angioneyropatii (Raynaud tus kab mob) ;
• lub plawv mob qhov muag;
• trophic cov ntaub so ntswg mob;
• trophic ulcers;
• hem kom nchuav menyuam;
• haumxeeb mob ntawm nruab nrab thiab inner pob ntseg;
• vascular impotence;
• npag dystrophy;
• gangrene, frostbite.

Contraindications

Uas kab mob txwv tsis pub siv cov tshuaj "Pentoxifylline?" Ib tug analogue ntawm cov tshuaj thiab cov tshuaj nws tus kheej tsis tau muab rau cov neeg uas intolerance mus rau lub ntsiab Cheebtsam, raws li zoo li lwm yam neeg sawv cev ntawm lub xanthine pab pawg neeg.

Nyob rau hauv tas li ntawd, qhov suav hais tias cov tshuaj txhob nyob rau hauv cov neeg mob uas muaj nyuam qhuav raug kev txom nyem ib hemorrhagic stroke los yog mob myocardial infarction raws li kev txom nyem los ntawm sab kev atherosclerosis lub plawv thiab lub hlwb hlab ntsha, porphyria.

Tso dej siv yeeb tshuaj yog txwv tsis pub rau arrhythmia, los ntshav, tsis tshua muaj ntshav siab, hemorrhages nyob rau hauv lub retina. Tsis tas li ntawd, cov tshuaj yog txhob thaum lub sij hawm lactation thiab hnub, cov me nyuam mus txog rau 18 xyoo.

Nrog tshwj xeeb ceev faj yog muab txhais tau tias cov ua neeg (nyob rau hauv thiaj li yuav tiv thaiv kom txhob los ntshav ntawm txheej week thiab hauv nruab nrog cev), thiab cov neeg mob uas muaj mob loj raum thiab lub siab, hnyuv rwj kab mob, gastritis thiab lub plawv tsis ua hauj lwm.

Txoj kev ntawm qhov kev siv

Yuav ua li cas siv cov tshuaj "Pentoxifylline?" Cov lus qhia rau kev siv, tiag tiag (analogues ntawm no lub cuab tam yuav muaj ntau noj tshuaj npaum cas) tej kws kho mob hais tias cov tshuaj no yog noj ntawm ncauj thiab parenterally (nyob ntawm seb lub heev ntawm tus kab mob no).

Ncauj thawj coj ntawm cov tshuaj pib nrog ib koob tshuaj ntawm 200 mg (i.e., 2 ntsiav tshuaj peb zaug ib hnub twg, tom qab ib tug noj mov). Tom qab ncav qhov teev xov tooj ntawm kho nyhuv yog txo los ntawm ib nrab. Hoob no ntawm kev kho mob tshuaj yuav tsum kav tsis muaj ntau tshaj li ib lub hlis.

Nyob rau hauv heev thiab mob cov kab mob ntawm hauv nruab nrog cev tshuaj muab nyob rau hauv tsiav tshuaj. Muaj 2 txoj kev ntawm yeeb tshuaj koom haum saib xyuas: tso dej thiab intraarterial. Tus thawj txoj kev ua los ntawm ib tug dropper. Rau lub hom phiaj no, 1 vial 250 ml qab zib tov los yog sodium tshuaj dawb. Hais tias ntau npaum yog muab tsis pub dhau 2 lub sij hawm.

Raws li rau intraarterial cov thawj coj, nws yog muab nyob rau hauv ib koob tshuaj ntawm 0.1 g ib 50 ml ntawm sodium tshuaj dawb tov.

phiv

Ntawm cov feem ntau phiv yog cov nram qab no:

• kiv taub hau, ntxhov siab vim, pw tsis taus, mob chua leeg, mus ob peb vas kev hloov, mob taub hau;
• cholecystitis exacerbation, txhawb siab transaminases, kev loj hlob cholestatic kab mob siab;
• ntuav, zoo nkaus li ntawm fullness nyob rau hauv lub plab, xeev siab, raws plab, tsis qab los noj mov;
• ua xua, anaphylactic poob siab, khaus, angioneurotic edema, lossis puas liab liab ntawm daim tawv nqaij;
• qhov tshwm sim ntawm arrhythmias, lub plawv mob, txo cov ntshav siab, stenokardicheskie mob;
• thrombocytopenia, leukopenia;
• kev pab, qhov muag plooj tsis pom kev;
• exacerbation ntawm mob hawb pob, bronchospasm, ua pa insufficiency;
• los ntshav ntawm txawv etiology.

Tshuaj "Pentoxifylline": analogues, nqe

Analogs pom tau hais tias cov tshuaj nram qab no tshuaj:

• dragees "Agapurin" (100 mg) thiab ib tug tov rau txhaj nyob rau hauv ampoules (100 mg);
• ntsiav tshuaj "Lauj kaub", coated ntsiav tshuaj (600 mg);
• dragees, ntsiav tshuaj thiab tshuaj tov "Trental".

Nws yuav tsum tau muab sau tseg hais tias "Trental" nruab nrab yog cov thawj cov tshuaj. Nws yog muab tso rau cov neeg mob uas encephalopathy ntawm txawv keeb kwm.

Raws li rau tus nqi, ces tag nrho cov kev npaj nws txawv. Analogue "Trental" "Pentoxifylline" yuav raug muas 120 rubles thawj medicament - rau 520 rubles "Agapurin" - 300 rubles, thaum lub sij hawm "Lauj kaub" - 400 rubles.

Xyuas

Xyuas txog cov tshuaj no yog mas zoo. Tshuaj yog zoo nyob rau hauv vascular cov kab mob ntawm ntau nruab nrog cev thiab tshuab. Feem ntau cov kev xyuas nyob rau kev siv ntawm "Pentoxifylline" twb tso tseg los ntawm cov txiv neej uas raug kev txom nyem los ntawm obliterating endarteritis nrog sib quas ntus claudication. Qhov no medicament yog rau lawv ib tug txhais tau tias № 1, txij li thaum tus kab mob no nyhav yuav vam meej.