"DioCore 160": cov lus qhia rau kev siv, tiag tiag counterparts. "DioCore solo 160": cov lus qhia rau kev siv, tiag tiag

Feem tooj ntawm cov neeg puav raug kev txom nyem los ntawm cov ntshav siab. Txawm li cas los, xws li ib tug pathological mob tsis tau tsuas yog theem tseem ceeb tsis xis nyob rau tus neeg mob, tab sis kuj hawv ua phem nws lub neej. Yog li ntawd, nyob rau hauv hnub no tus kws ua lag luam muaj ntau ntau yam khoom uas ua rau kom txos cov ntshav siab.

Cov feem nrov ntawm cov neeg cov neeg uas tsis tu ncua raug kev txom nyem los ntawm tawg, siv ib tug yeeb tshuaj raws li "DioCore 160". Cov lus qhia rau kev siv, analogues cov tshuaj no, raws li zoo raws li kev txheeb xyuas txog nws, nta thiab cov khoom yuav tsum tau nthuav tawm ib tug me ntsis rau yav tom ntej.

Muaj pes tsawg leeg, hauj lwm, ntim thiab zoo

Tshuaj "DioCore 160", cov nqe lus yog muaj nyob rau hauv ib lub thawv uas ua los ntawm cov duab los qhia, manufactured nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj. Lawv yog cov zaj duab xis-coated thiab muaj xws active cov khoom xyaw li valsartan thiab hydrochlorothiazide. Tsis tas li ntawd qhov qhia txhais tau tias muaj xws li microcrystalline cellulose, sodium lauryl sulfate, qos starch, talc, pob kws starch, croscarmellose sodium, magnesium stearate, colloidal anhydrous silica thiab opadry II Txiv kab ntxwv.

Peb tsis tau hais tias xws li ib tug yeeb tshuaj, thiab muaj peev xwm nrhiav tau rau ntawm kev muag khoom raws li "DioCore Solo 160". Los ntawm cov ua ntej nws txawv nyob rau hauv hais tias nws cov active ingredient ua xwb valsartan.

Lub hauv paus ntsiab lus ntawm cov lag luam ntawm ib tug medicament

Yuav ua li cas yog cov tshuaj "DioCore 160"? Cov lus qhia rau kev siv cov ntawv qhia hais tias qhov no antihypertensive neeg sawv cev, uas yog tsim los ntawm ib tug thiazide diuretic thiab ib tug angiotensin receptor II antagonist.

Qhov cuab yeej no muaj ib tug ntau yam ntawm muaj sia los uas yog npaum li cas raws li indirect thiab ncaj qha ib feem nyob rau hauv cov ntshav siab kev cai. Angiotensin II yog ib tug haib vasoconstrictor neeg sawv cev los ntawm ib tug ncaj qha pressor nyhuv. Nws kuj ncua lub sodium thiab nkoos lub tso pa tawm ntawm aldosterone.

Valsartan hu ua kom nquag plias thiab kev angiotensin receptor II antagonist. Nws yog tsim los rau qhov ncauj saib xyuas thiab xaiv ua yeeb yam nyob rau hauv lub AT1 receptor subtype uas yog lub luag hauj lwm rau cov teebmeem ntawm angiotensin II. Ib nrab agonist kev ua si nyob rau receptor subtype AT1, qhov no caij tsis qhia.

Tsis tas li ntawd valsartan tsis inhibit ACE, uas converts angiotensin kuv mus angiotensin II, bradykinin rhuav tseg. Tsis cai thiab kev phiv los ntawm bradykinin.

Nyob rau hauv cov neeg uas kub siab, cov tshuaj ua rau ib tug txo nyob rau hauv cov ntshav siab. Nyob rau hauv cov ntaub ntawv no, nws twb tsis muaj ntxim rau lub plawv dhia.

Muaj ntau cov neeg mob tom qab ib tug tib koob tshuaj ntawm cov kev kawm tshuaj pib antihypertensive ua si cai tsis pub dhau 2 teev, thiab cov ntshav siab yuav txo tau tshaj 6 teev.

Lub antihypertensive nyhuv ntawm cov tshuaj mob tsawv rau ntau tshaj ib hnub. Thaum tsis tu ncua ntsiav tshuaj tshaj plaws kho nyhuv yog tiav tsis pub dhau plaub lub lis piam thiab khaws cia thoob plaws hauv lub chav kawm ntawm ntev-lub sij hawm kev kho mob.

tshuaj

Yuav ua li cas yog lub xam qhovkev kev tig tau thaj chaw ntawm lub medicament "DioCore 160"? Cov lus qhia rau kev siv (ntsiav tshuaj yuav tsum tau muab xwb tus kws kho mob) hais tias tom qab noj cov tshuaj rau hauv lub nqus ntawm hydrochlorothiazide thiab valsartan yog heev ceev ceev. Qhov nruab nrab tsis bioavailability ntawm no neeg sawv cev yog 23%.

Lub kinetics ntawm valsartan yog linear. Ua kev siv ntawm cov tshuaj tsis dais tej kev hloov. Nrog ib tug tib ntsiav tshuaj ntawm lawv txuam nrog yog negligible.

Valsartan yog ua txhua yam rau ntshav cov nqaijrog ntawm 94-98%. Nws feem yog nqa tawm nrog rau cov quav thiab zis. Thaum noj ua ke nrog rau cov AUC ntawm valsartan zaub mov yog txo los ntawm 48%.

Tom qab tau txais cov ntsiav tshuaj hauv hydrochlorothiazide haum tshwm sim es sai sai (txog 2 teev). Ntxiv mus, nws bioavailability yog 60-80%. Qhia rau nws nyob rau hauv cov zis.

Nrog ua ke nrog ntawm valsartan thiab hydrochlorothiazide mauj bioavailability ntawm lub yav tas yog txo los ntawm kwv yees li 30%.

indications ntsiav tshuaj

Nyob rau hauv dab tsi tej yam kev mob rau tus neeg mob tej zaum yuav tau tsa tshuaj "DioCore 160"? Cov lus qhia rau kev siv, tiag tiag cov kws kho mob qhia tias qhov cuab tam yog heev zoo tshwm sim rau nws tus kheej nyob rau hauv tawg, raws li zoo raws li cov tsis muaj hauj lwm zoo ntawm tus kab mob no nyob ib leeg.

Contraindications kom tau txais cov ntsiav tshuaj

Koj puas paub tias nyob rau hauv tej rooj plaub, tsis muab tshuaj "DioCore 160"? Phau ntawv lub xeev hais tias xws li cov tshuaj yog ua rau ib tug neeg intolerance ntawm nws cov khoom xyaw.

Nyob rau hauv tas li ntawd, nws yog txwv tsis pub rau siv nyob rau hauv cov neeg mob uas cholestasis, mob siab puas, thiab biliary mob npuas paug. Tsis tas li ntawd, nws tsis yog tshuaj rau cov neeg uas raug kev txom nyem los ntawm ib daim ntawv uas mob loj heev thiab muaj mob loj tsawv raum tsis ua hauj lwm, ib cov tsos mob ntawm anuria, txo sodium thiab potassium ntau nyob rau hauv cov ntshav, hypercalcemia thiab hyperuricemia.

Ntsiav tshuaj "DioCore 160": cov lus qhia rau kev siv

Raws li ib tug dav dav txoj cai, los mus tshem tawm cov ntshav siab nyob rau hauv tsev rau cov neeg mob pom zoo kom siv ntawm ib ntsiav tshuaj "DioCore 80" ib zaug ib hnub twg. Raws li rau lub "DioCore 160" ntawm cov tshuaj, nws yog tshuaj xwb nyob rau hauv lub tsev kho mob. Nyob rau hauv cov ntaub ntawv no, tus neeg mob yuav tsum tau nyob rau hauv lub qhov kev saib xyuas ntawm ib tug kws kho mob.

Raws li kev xyaum qhia tau hais tias, ib tug hnov li thaum muaj zog tawg cai 2-3 lub lis piam tom qab pib ntawm txoj kev kho.

Rau cov neeg uas muaj mob loj tsawv lossis tseem ceeb hepatic los yog lub raum tsis ua haujlwm zoo yuav tsum tau nqa tawm tsim nyog kho ntawm lub ntau npaum ntau (ib lub zuj zus).

Lub caij ntawm kev kho mob nrog rau qhov no tshuaj yuav tsum tau txiav txim los ntawm lub mus kawm tus kws kho mob.

phiv

Yuav ua li cas hom ntawm cov kev phiv rau tus neeg mob yuav tsum tau paub txog ua ntej koj yuav siv ib cov tshuaj "DioCore Solo 160"? Cov lus qhia rau Siv lub xeev uas xam tau tias yog tshuaj tsis tshua muaj ua rau kev phiv txheej xwm uas muaj tsis ruaj tsis khov thiab mob-txhais cim.

Kwv yees li 1% ntawm cov neeg mob thaum noj cov tshuaj no nyob tsis muaj zog mob taub hau, rov qab mob, qaug zog, hnoos, kiv taub hau thiab nasopharyngitis.

Tsawg dua 1% tsis yws hlo li ntawm mob plab, ntxhov siab vim, tsis xis nyob rau hauv lub caj dab thiab hauv siab, qaug zog, mob tej pob txha, serous bronchitis, nkees nkees, laryngitis, ua tsis taus pa, raws plab mob, txo erection, txo salivation, hypotension, Gastroenteritis, paresthesia, nce tawm hws, tsis rhiab heev, nqaij tu-sauv, insomnia, peripheral edema, xeev siab, mob pob ntseg, qhov ntswg congestion thiab ib tug me ntsis sawv nyob rau hauv lub cev kub. Tej zaum cov neeg mob tau lus zoo tsis pom kev, tsis ruaj tsis khov tachycardia thiab tinnitus. Nws yuav tsum tau muab sau tseg hais tias ib tug ncaj qha kev sib raug zoo nrog qhov tshwm sim ntawm cov tshuaj thiab cov tshuaj tsis tau tsim muaj.

Yuav ua li cas lwm sab los yuav ua rau cov tshuaj "DioCore Solo 160"? Cov lus qhia nyob rau hauv daim ntawv thov hais tias thaum uas siv cov cuab tam, muaj cais tus neeg mob ntawm qhov pib ntawm pob, khaus thiab lwm yam kev tsis haum ces, xws li vasculitis, thiab ntshiab kev mob kev nkeeg. Nyob rau hauv tas li ntawd, cov neeg mob tej zaum tsim myalgias thiab nefralnaya kawg.

Heev tsawg daim ntawv ntawm cov kev phiv thaum noj "DioCore 160" cov khoom no yog ib qho yooj yim uas tsis yog-cardiogenic edema uas yog txuam nrog ib tug neeg intolerance ntawm hydrochlorothiazide.

Kev tshawb fawb tau qhia tias nyob rau hauv ib co neeg mob kho nrog no lub cuab tam, tsis poov tshuaj nyob rau hauv cov ntshav, elevating creatinine thiab urea, raws li zoo raws li paub me ntsis neutropenia.

tsos mob ntawm overdose

Yuav ua li cas yog cov tsos mob "DioCore Solo 160" uas muaj koob ntawm cov tshuaj? Phau ntawv hais tias xws li mob yog tsis paub hais tias lub sij hawm no.

Lub ntsiab kos npe rau ntawm nce koob tshuaj yuav ua tau mob hnyav hypotension. Yog hais tias cov tshuaj tau txais kuj ntev los no, tus neeg mob yuav tsum tau artificially ntxias ntuav. Tsis tas li ntawd kev sib ntaus los hypotension tej zaum yuav nqa tawm los ntawm tso dej thawj coj ntawm tej saline.

Nws yuav tsum tau nco ntsoov hais tias hais tias nws yog tsis yooj yim sua rau deduce qhov suav hais tias cov tshuaj los ntawm lub cev los ntawm hemodialysis. Qhov no yog vim lub fact tias valsartin, muaj nyob rau hauv nws cov muaj pes tsawg leeg, nws reacts nrog cov ntshav proteins. Txawm li cas los, nws yuav tsum tau muab sau tseg tias hydrochlorothiazide yog tshem tawm nyob rau hauv no txoj kev heev ntse.

Tshuaj kev sib tshuam nrog lwm yam tshuaj

Yog nws tau mus ua ke nrog rau lwm cov txhais tau tias "DioCore 160"? Instruction hais tias ua ke nrog ntawm cov tshuaj no nrog rau lwm cov antihypertensive tshuaj pab pawg neeg yuav ua rau kom txhim khu cov nyhuv ntawm tej ntshav siab.

Lub simultaneous siv cov medicament nrog poov tshuaj-uas muaj additives, me me diuretics, solezamenitelyami thiab tshuaj uas ua rau kom cov ntsiab lus ntawm poov tshuaj nyob rau hauv lub cev, yuav tsum xeem concentration ntawm poov tshuaj nyob rau hauv cov ntshav ntshiab.

Thaum simultaneous thawj coj "DioCore" nrog ACE inhibitors tau lawm tias reversible nce nyob rau hauv lub concentration ntawm lithium nyob rau hauv cov ntshav.

Yuav ua li cas cov tshuaj yuav xyuam xim siv cov tshuaj "DioCore 160"? Phau Ntawv Qhia hais tias monotherapy tawg qhov cuab tam yog tsis cai tej sis raug zoo nrog cov "glibenclamide", "amlodipine", "warfarin", "cimetidine", "Digoxin", "furosemide", "indomethacin" Atenolol ".

Txij li thaum cov tshuaj nyob rau hauv muaj pes tsawg leeg nyob rau hauv saib xyuas muaj xws li thiazide diuretic pab pawg neeg, nws tej zaum nram qab no sib tshuam:

• txo nyob rau hauv diuretic nyhuv ntawm cov tshuaj thaum nws yog siv ua ke nrog lub NSAID (e.g., salicylates los yog "Indomethacin");
• potentiation ntawm nqaij hnaiv.

Yuav ua li cas lwm yam yeeb tshuaj cov kev sib tshuam yuav tsum paub ua ntej yuav noj cov "DioCore 160"? Cov lus qhia, xyuas qhia tias thaum uas siv cov no lub cuab tam nrog kaliynesberegayuschimi diuretics, salicylates, ACTH, amphotericin karbenokslolonom thiab tejzaum nws ib tug ntse txo nyob rau hauv lub concentration ntawm poov tshuaj nyob rau hauv cov ntshav.

Thaum siv tshuaj thiab qhov ncauj antidiabetic cov tshuaj yuav tsum tau nqa tawm ib lub zuj zus kho lawv npaum li cas.

Nws tsis pom zoo kom siv cov xam tau tias yog medicament ua ke nrog diuretics thiazide pab pawg neeg, raws li qhov no yuav ua kom nrov loj saum toj no-hais sab los ntawm cov tshuaj thiab mus ua npau taws me ntsis kev tshua.

Thaum ua ntawv thov ib txhij nrog methyldopa hydrochlorothiazide yuav tsim hemolytic anemia.

Thaum ua ke tshuaj "DioCore 160" nrog kolestiraminom txo nws bioavailability thiab haum.

Ua ntej cov tshuaj uas muaj vitamin D nyob rau hauv cov ntshav calcium concentration yuav tau nce nyob rau hauv cov neeg mob.

Nws yog txwv tsis pub nqa mus siv rau "DioCore" nrog cyclosporine, raws li qhov no yuav ua rau cov tsos mob thiab mob podagropodobnye giperurikekii.

Cov tswv yim pom zoo nyob rau hauv cov ntsiav tshuaj

Yuav ua li cas koj yuav tsum paub ua ntej koj siv cov tshuaj "DioCore Solo 160"? Cov lus qhia rau kev siv, xyuas hais tias thaum lub sij hawm kev kho mob nrog rau qhov no neeg sawv cev nyob rau hauv tus neeg mob yuav tsum tau kev saib xyuas ntawm ntshiab theem ntawm electrolytes nyob rau hauv cov ntshav.

Nrog rau txoj kev loj hlob ntawm lub cuam tshuam hypotension yuav tsum tau hloov dua siab tshiab rau hauv ib tug kab rov tav txoj hauj lwm. Yog hais tias yuav tsum tau, nqa tawm ib qho kev tso dej Txoj kev lis ntshav ntawm ib txwm saline. Tom qab stabilizing lub siab kev kho mob tej zaum yuav tau mus ntxiv.

Cov neeg uas muaj unilateral los yog ob sab sib dho raum leeg stenosis txais valsartan tej zaum yuav ua ib qho kev nce nyob rau hauv cov ntshiab creatinine los sis cov ntshav urea.

Thaum muab tus medicament rau cov neeg mob nrog impaired raum muaj nuj nqi koob tshuaj hloov yog yuav tsum tau, tab sis yuav tsum tau periodic xyuas ntawm creatinine thiab uric acid, thiab poov tshuaj ntsiab lus ntawm cov ntshav.

Muaj pov thawj hais tias thiazide diuretics yuav exacerbate mauj lupus erythematosus. lawv kuj hloov glucose siab tev taus ntawm tus neeg mob, ua rau kom lub concentration ntawm cov roj uas txhaws, thiab uric acid nyob rau hauv cov ntshav triglyceride. Nyob rau hauv no hais txog, cov neeg mob uas mob ntshav qab zib tej zaum yuav tsum tau hloov li cas lawm ntawm cov tshuaj ntawm qhov ncauj hypoglycemic kab mob los yog insulin.

Nyob rau hauv cov neeg mob uas muaj mob loj tsawv thiab me siab puas tsis cholestasis cov tshuaj hloov yog yuav tsum tau. Tab sis nyob rau hauv cov tej yam kev mob cov tshuaj yuav tsum tau noj nrog huab ceev faj.

Muaj cov ntaub ntawv ntawm photosensitivity thaum lub sij hawm kev kho mob nrog thiazide diuretics. Yog hais tias nyob rau hauv lub chav kawm ntawm kev kho nrog no txhais tau tias yog ib tug tshuaj tiv thaiv ntawm photosensitivity, kev kho mob yuav tsum tau txiav.

Yog hais tias tsim nyog, rov thawj coj ntawm ib tug diuretic yog pom zoo los tiv thaiv lam tau lam ua feem ntawm cov khoom cua ultraviolet tawg los yog lub hnub.

tshuaj analogues

Yuav ua li cas yuav muab suav hais tias hloov peb txhais tau tias? Raws li txawj zoo xws li cov zog yog tshuaj xws li "Air-hiav txwv", "Dentokind", "Intsena", "Cinnabsin", "Softovak", "Medotsef" "Vinblastine-Teva".

Xyuas ntawm kev npaj

Tam sim no uas koj paub yuav ua li cas siv cov tshuaj "DioCore 160". Cov lus qhia rau kev siv cov tshuaj no twb tau piav nyob rau hauv kom meej saum toj no.

Qhov cuab yeej no yog heev nrov nrog cov neeg mob thiab cov kws kho mob. Kws txawj qhia hais tias nws zoo manifests nws tus kheej nyob rau hauv lub xub ntiag ntawm mob loj heev arterial hyperplasia. Tau txais kev pab tag nrho pom zoo nrog rau qhov no. Raws li lawv cov lus teb, kev noj ib ntsiav tshuaj txhawb restoration ntawm cov ntshav siab, raws li tau zoo raws li pab txhawb lawv tus mob.

Nws yog tsis yooj yim sua tsis tau nco ntsoov lub fact tias cov tshuaj muaj ib tug yooj yim hauv daim ntawv ntawm kev tso cai thiab ntau npaum. Txawm li cas los, kev noj ib tug ntau dua koob ntawm cov tshuaj yuav tsum tsuas yog nyob rau hauv lub tsev kho mob, nyob rau hauv lub saib xyuas ntawm ib tug kws kho mob.