Bacteriophages: hom thiab lub hom phiaj

Phage lysis - tus txheej txheem ntawm kev puas tsuaj ntawm cov kab mob los ntawm phages, feem ntau yog tshwm sim nyob rau hauv lub cuam tshuam hloov thaum txawj rov qab. Yog hais tias nws tus kheej-kho tsis tau tshwm sim, lub cev yuav tsum tau pab los ntawm plaug lub sib nug xov bacteriophage, uas ua rau ib tug kws lub tuam txhab. Hu bacteriophages kab mob cov kab mob uas txeem thiab ua rau lawv nyias mus nyias (lysis) nyob rau hauv ib tug lub rooj sib tham nrog nws raug rau microbial hlwb.

Nyob rau hauv Greek bacteriophage txhais tau tias "eater ntawm cov kab mob." Nyob rau hauv cov xwm, cov kab mob yog heev ntau haiv neeg thiab yog cov coob ntawm cov tam sim no lub npe hu kab pawg. Phages yog cov kab mob sib txawv ntawm cov nroj tsuag, tsiaj txhu thiab tib neeg tus qauv, muaj ntau nyuaj. Lawv muaj nyob rau hauv los nag, cua, cov av, cov zaub mov, nyob rau hauv kev kawm daim tawv nqaij, tsiaj ntaub plaub, nyob rau hauv luv luv, peb txog qhov twg muaj tus kab mob no.

Nyob rau hauv xyoo tsis ntev los, ib tug loj hlob txaus siab nyob rau hauv bacteriophages yog siv raws li ib tug lwm txoj rau tshuaj tua kab mob. Qhov no yog vim li, thiab cov neeg thiab lwm yam tshuaj ncaj qha kev cuam tshuam rau cov pathogens. Txawm li cas los, tshuaj tua kab mob paub nyhuv dejnum tsis tsuas yog nyob rau hauv lub pathogenic muaj, tab sis kuj rau lub chaw tso dej. Bacteriophages, hom uas yog cov sib txawv, ua xaiv, tsuas yog rau cov "lawv" cov kab mob, tawm hauv lub wreckage ntawm nws. Ua tau, yog li zaum thiab tsis txua lawv cov npe, nws yog yooj yim npaum li mus hu lawv feem cov kab mob uas lawv raug.

Bacteriophages: Hom

Tsim streptococcal, coliform Proteaceae, klebsiellezny, Staphylococcus, Pseudomonas, Salmonella, dysentery, typhoid bacteriophage raws li "Intestifag" thiab "Piobakteriofag".

Active npaj yog txiav txim los ntawm lawv cov degree ntawm dilution ntawm uas tus lysis rhiab kab lis kev cai. Yog li, titer ntawm 10 nyob rau hauv lub thib ob degree txhais tau tias teev lytic bacteriophage active zog ntawm ib tug dilution ntawm 1 000 000 lub sij hawm. Thaum ib tug kub ntawm 4-6 C tshuaj lawv khaws lawv lub zog mus rau 12 xyoo.

Nyob rau qhov kev tso tawm cov ntaub ntawv uas txawv nyob rau hauv kev ua si bacteriophages. Hom tshuaj yuav muaj kev cuam tshuam ob leeg tus neeg pathogens, thiab rau ob peb zaug. Monophages cuam tshuam ob peb kab mob los ntawm lub tib lub kab mob. K complex npaj (polyvalent) muaj xws li bacteriophage "Sekstafag" uas yog tau ib txhij inhibit qhov kev ua si ntawm staphylococci, streptococci, xws li Enterococci, Pseudomonas thiab Escherichia coli, Proteus, Klebsiella. Tsis tas li ntawd, muaj ib tug "Intestifag" npaj rau cov kev kho mob ntawm plab hnyuv kab mob, nws muaj ib tug kab mob Salmonella, typhoid, dysentery, proteus, coli thiab streptococcal (suppressing Enterococci) phages.

Tshuaj siv nyob rau hauv dysbacteriosis, plab hnyuv kab mob, inflammations ntawm lub urogenital system thiab broncho-pulmonary apparatus los kho tus mob lub taub dej khawb dab, raws li tau zoo raws li cov kab mob ntawm lub qhov ncauj kab noj hniav thiab sinuses. Lawv yog siv raws li lub sab hauv, xws li nyob rau hauv daim ntawv ntawm cov enemas, thiab zos - mus yaug, ntxuav lub qhov txhab, douching. Piv txwv li, "Tus Bacteriophage Klebsiella polyvalent lim" rau cov kev kho mob ozeny, rinoskleromy, kab mob tshwm sim los ntawm tus kab mob Klebsiella mob ntsws, siv los ntawm nqus tau pa ntawm qhov txhab raj cua, lub suab thiab lub caj pas, muab turunda soaked nyob rau hauv cov kua, otitis, siv rau kev ntxuav nyob rau hauv sinusitis. Thaum cystitis, enterocolitis, urethritis, mob ntsws tshuaj no yog coj hais lus.

Bacteriophages muaj ib tug loj ntawm zoo tshaj tshuaj tua kab mob. Lawv muaj tsis muaj kev phiv, lawv raug txawm me nyuam mos thiab cev xeeb tub cov poj niam, lawv tsis hom. Lawv yuav tsum tau ua ke nrog rau tej tshuaj, raws li zoo raws li cov kev siv rau kev tiv thaiv ntawm kis kab mob. Cov kev npaj muaj ib pab cawv rau txoj kev loj hlob ntawm kev tiv thaiv, tsis txhob suppress lub ntuj muaj thiab lawv cov nyhuv yog pom li 2-4 teev tom qab haus. Lawv tsis tsim kuj pathogens.

Ib drawback yog bacteriophages. Hom kev siv niaj hnub no nyob rau hauv cov tshuaj, tsis tau ob peb, uas txwv lawv siv nyob rau hauv ntau mob.

Outlook daim ntawv thov

Nyob rau hauv thiaj li yuav ntse thov lom khoom, nws yog tsim nyog los mus txiav txim qhov rhiab heev ntawm cov kab mob mus rau lawv. Txawm li cas los, zaum tau pom ib qho kev nthuav qauv: rhiab heev ntawm kab ntawd los phages yog tsis txo, tab sis, theej tsub kom, vim lub kawm ntawm cov khoom uas tshiab haiv neeg. Rau hnub tim, lub bacteriophage staphylococcal ntse lyse 90% ntawm tag nrho cov hom ntawm tus kab mob tso thaum lub sij hawm lub taub dej khawb txhab.

Muaj ntau hom kab mob tshwj xeeb ntseeg tau hais tias phage txoj kev kho yuav sai sai no revolutionize lub sib ntaus tawm tsam cov kab mob. Immunologists saib lub zeem muag ntawm txoj kev siv ntawm cov nyiaj no nyob qhov twg Immunopreparat powerless. Raws li cov kev tshawb fawb analytical nyob rau hauv lub tom ntej no ob peb xyoos, ib tug ntawm cov feem ntau pheej chaw ntawm pharmacology yuav zus tau tej cov phages.