Tshuaj tua kab mob "Linezolid": cov lus qhia rau kev siv, nqe counterparts, qhov kev tso tawm daim ntawv thiab xyuas

Feem ntau ntawm cov paub tshuaj kab mob los yog kab mob amenable rau kev kho mob los ntawm cov pa tshuaj. Txawm li cas los, muaj pathogens uas tau yoog mus rau thiaj li hu ua nosocomial tej yam kev mob. Lub sib ntaus tawm tsam lawv yog ib tug heev nyuaj ua hauj lwm, vim hais tias muaj ntau yam tshuaj lawv tsuas tsis ua hauj lwm. Tshuaj tua kab mob "linezolid" yog hais txog cov tshuaj uas muaj peev xwm yuav hais txog nrog thiaj li hu ua nosocomial kab mob los yog lwm yam resistant mus rau lwm cov hom ntawm cov tshuaj. Uas yog hais txog nws thiab yuav tsum tau tham nyob rau hauv no tsab xov xwm.

piav qhia

Tshuaj "Linezolid" cov lus qhia ua ntawv thov rau antimicrobial broad-spectrum. Raws li nws yooj yim zog thiab cov yam ntxwv nws belongs rau lub chav kawm ntawv oxazolidinone uas lub dag lub zog thiab ntau yam txiav txim tawm tsam kab mob nyob rau hauv ntau lub respects superior mus rau yeeb tshuaj "vancomycin" thiab lwm yam khoom nrog ib tug zoo xws li cov muaj pes tsawg leeg.

Niaj hnub no, muaj ntau ntau hom ntawm antimicrobial neeg sawv cev "linezolid". Khoom daim ntawv no, yog feem ntau siv rau kev kho mob, - ib tug membrane plhaub ntsiav tshuaj uas muaj 400 los yog 600 mg ntawm active tshuaj. Nyob rau hauv tas li ntawd, nyob rau hauv kev kho mob xyaum Txoj kev lis ntshav tov yog feem ntau siv, uas nyob rau hauv txhua milliliter muaj 2 mg ntawm active tshuaj thiab cov hmoov (granules) los npaj ib ncua kev kawm, lub concentration ntawm lub active ingredient uas yog 100 mg rau ib 5 ml ntawm khoom zaum kawg.

indications

Raws li hais ua ntej lawm nyob rau hauv no tsab xov xwm, cov tshuaj "Linezolid" phau ntawv qhia xav kom koj siv cov muaj kab mob tshwm sim los ntawm cov kab mob resistant mus rau lwm cov tshuaj tua kab mob. Cov no muaj xws ob gram-zoo thiab gram-tsis zoo kab mob teej tug mus rau lub co los yog aerobic hom uas tau tsim kuj (stability) rau methicillin, gikopeptidnym tebchaw, penicillin thiab lwm yam tshuaj tua kab mob.

Daim ntawv ntawm cov kab mob uas ib tug "linezolid" medicament qhia muaj xws li:

• lub tsev kho mob los yog lub zej lub zos mas yuav kis tau mob ntsws;
• daim tawv nqaij kab mob;
• nqaij mos;
• Lwm yam kab mob tshwm sim los ntawm cov tshuaj tua kab-resistant Enterococcus.

Raws li ib tug txoj cai, ua ntej yuav siv cov tshuaj no ua cov kev tshawb fawb kom paub tias cov kuj ntawm pathogens rau lwm yam tshuaj. Yog hais tias tsis muaj leej twg nyob, kev kho mob yog nqa tawm nrog kev pab los ntawm lwm yam antimicrobial tshuaj.

Contraindications

Lub ntsiab thiab tseem ceeb tshaj plaws contraindication rau kev siv ntawm cov tshuaj tua kab mob 'Linezolid cov lus qhia rau kev siv hais txog meem kev txhawj xeeb rau nws. Nws kuj tsis pom zoo kom siv cov tshuaj rau kev kho mob ntawm cov neeg mob uas noj lwm yam tshuaj los ntawm cov pab pawg neeg ntawm Mao inhibitors. Nyob rau hauv tas li ntawd, nws tsis pom zoo rau qhov no neeg sawv cev ua ke nrog tricyclic antidepressants thiab tshuaj muaj peev xwm mus nce ntshav siab (epinephrine, dopamine, thiab lwm yam triptan).

Kev npaj "linezolid" (ntsiav tshuaj, Txoj kev lis ntshav tov thiab cov slurry) yog ua rau cov kab mob xws li tawg, hyperthyroidism, los yog seratoninovy carcinoid syndrome, feohromotsitoz. Lub xub ntiag ntawm cov contraindications yuav tsum tau kuaj ua ntej pib ntawm txoj kev kho siv cov tshuaj.

Mechanism ntawm kev txiav txim ntawm cov tshuaj nyob rau hauv lub cev

Action "Linezolid" tshuaj vim nws muaj peev xwm los thaiv tus neeg txhais lus txheej txheem ntawm protein lug nyob rau hauv lub hlwb ntawm cov kab mob. Vim lub loj hlob ntawm kab mob yog nres thiab muaj lawv tuag. Kuj mus rau yeeb tshuaj nyob rau hauv feem ntau ntawm cov kab mob yog ua heev maj mam.

Tom qab haus ntawm cov tshuaj active ingredient ntaub ntawv lub metabolite hydroxyethyl glycine. Lub degree ntawm nws cov koom haum nrog ntshav cov nqaijrog achieves ib tug 31% kev kawm. Nyob rau hauv laboratory kev tshawb fawb pom tias cov compound penetrates mus rau hauv tag nrho cov ntaub so ntswg thiab kabmob. Nws kuj muaj cov muaj peev xwm kis tau los ntawm lub tsev me nyuam mus rau hauv lub fetus thiab kua mis (cov cuab yeej ntawm tus tshuaj no yog thaws rov los nyob rau hauv lub tswv yim pom zoo ntawm kev noj cov tshuaj los ntawm cev xeeb tub thiab lactating cov poj niam).

Lub ib nrab-lub neej ntawm lub active tshuaj thiab nws metabolite tas yog 4.5-5 lub sij hawm. Feem yog los ntawm cov urinary system (50% raws li ib tug metabolite thiab 35% lawm), thiab los ntawm cov hnyuv (tsis tsawg tshaj li 9%). Sau kom tiav feem tshwm sim nyob rau 8-12 teev tom qab tau txais medicament.

Yuav ua li cas tau "Linezolid"

Kws txawj taw tes kom paub tias nyob rau hauv feem ntau tus neeg mob yuav tsis ntawm nws tus kheej txiav txim siab nyob rau hauv txoj kev ntawm kev txais tos "Linezolid" tshuaj. Ceeb toom, ntsiav tshuaj, kev daws teeb meem thiab emulsions uas yog tsis suav tias yog li cais npaj, thiab raws li ib daim ntawv ntawm cov tshuaj, uas muaj nyob rau ntawm no point paub meej tas nrho. Hauv qab no yog cov ntsiab lus tseem ceeb hais txog lub tshuaj thiab ntev ntawm txoj kev kho.

Tshuaj "Linezolid" phau ntawv qhia qhia siv cov hauv qab no schemes:

1. Ib tug tov rau Txoj kev lis ntshav yog muab intravenously 2 lub sij hawm ib hnub twg. Ib tug tib koob tshuaj 400-600 mg active tshuaj. Lub caij ntawm kev kho mob nyob rau hauv lub heev ntawm tus kab mob no thiab nws cov localization. Feem ntau, feem coob tau mob yuav tsum tau ib lub sij hawm tsawg kawg yog 10 thiab tsis muaj ntau tshaj li 14 hnub, thiab tsuas yog nyob rau hauv cov kab mob tshwm sim los ntawm Enterococci, kev kho mob kav los ntawm 2 mus rau 4 lub lis piam.
2. Kev npaj "linezolid" (ntsiav tshuaj) yog coj raws li 2 lub sij hawm ib hnub twg nyob rau hauv ib tug npaum li ntawm 400 los yog 600 mg rau ib txais tos. Rau cov neeg mob muaj hnub nyoog li 5 mus rau 14 xyoo, ntau npaum yuav muab xam rau ntawm lub hauv paus ntawm lub cev hnyav thiab yog 10 mg rau ib 1 kg ntawm lub cev hnyav, 2 lub sij hawm ib hnub twg. Qhov siab tshaj plaws tshuaj rau ib haus (p.o.) yuav tsum tsis pub tshaj 600 mg. Lub caij ntawm txoj kev kho yog txiav txim los ntawm tib lub tsis uas raug xam tias yog saum toj no.
3. Granules, uas yog ua los ntawm ib tug emulsion, thov los ntawm cov saum toj no cov tswvyim. ntau npaum xam thaum nws yog tsim nyog los nqa tawm raws li cov tib cov lus qhia.

Txij li thaum cov tshuaj "Linezolid" yog muab heev dua lwm yam los ntawm cov tshuaj thiab yog siv xwb nyob rau hauv lub tsev kho mob, ib tug overdose ntawm lub tsev no thiab cov tsos ntawm pronounced sab los yog zoo tshem tawm. Cov kws kho mob nyob rau hauv lawv cov kev txheeb xyuas hais tus neeg mob tshaj txuam nrog nyob rau hauv lub cev ntawm lub active tshuaj tshuaj thiab nws cov metabolites vim mob ntawm lub urinary nruab nrog cev thiab lub siab. Lub txim ntawm xws overdoses yog feem ntau heev sai sai tshem tawm, raws li tus neeg mob yog raug kho nyob rau hauv lub qhov kev saib xyuas ntawm cov kws tshwj xeeb.

tshuaj cov kev sib tshuam

Txij li thaum ib tug ntawm cov tshuaj ntaub ntawv ntawm qhov tshuaj "linezolid" yog npaj rau tso dej thawj coj, nws yog ib qho tseem ceeb tias cov tshuaj yog kiag li tau tshaj qhov yooj yim kev daws teeb meem siv thaum lub sij hawm kev kho mob (5% zib tov, 0.9% tov ntawm sodium tshuaj dawb thiab Ringer tus tov).

Kev mloog yuav tsum tau them mus rau lub zwj ceeb ntawm cov neeg mob, uas nyob rau hauv tas li ntawd mus rau "Linezolid" coj adrenergic tshuaj. Yog hais tias ib tug ua tiav tsis ntawm lub yav tas yog tsis tau, cov kws kho mob xav tau los saib xyuas lawv cov tshuaj.

Tshuaj "Linezolid '(zoo xws li cov nyob rau hauv muaj pes tsawg leeg kuj yuav equated rau nws) yog tau siab tshaj lub tshuaj" Chlorpromazine "," Cotrimoxazole "" Diazepam "thiab" Phenytoin ". Yog hais tias tus neeg mob ua ntej daim ntawv thov ntawm cov tshuaj tua kab mob coj hais tias txhais tau hais tias yog tau los txhawb nqa luv 3 hnub ua ntej kev kho mob "linezolid" kev npaj.

ceev faj

Raws li ntxiv tswv yim pom zoo nyob rau kev siv ntawm tshuaj tua kab mob "Linezolid" phau ntawv qhia no muaj cov lus qhia hais txog cov poj niam xeeb tub thiab cov neeg uas twb muaj lawm comorbidities. Nyob rau hauv tas li ntawd, nws cov ntsiab lus mus rau lub tseem phiv. Tiam sis ua ntej tej yam uas ua ntej.

Raws li rau lub txais tos "Linezolid" tshuaj xyuas ntawm cov kws kho mob tham txog kev ceev faj thaum siv rau cov cev xeeb tub thiab lactating cov poj niam. Qhov no yog vim lub fact tias cov nyhuv uas cov tshuaj rau hauv lub tsim fetus los yog tus me nyuam mos tus me nyuam tau raug insufficiently kawm. Feem ntau, kev kho mob yog nrog nws siv tsuas yog hu yog tias qhov uas yuav kom cov me nyuam hauv plab ho hauv qab no cov kev tsim pab rau cov niam.

Ib tug nyuaj lub raum thiab hepatic tsis ua hauj lwm, kuj yuav tsum tau ceev faj daim ntawv thov ntawm cov tshuaj, vim hais tias metabolites yog tas mas nyob rau hauv cov kabmob, thiab txuam nrog ntawm cov tshuaj nyob rau hauv lawv tej zaum yuav ua rau deterioration ntawm tus neeg mob.

phiv

Raws li cov ntsiab ntawm cov kev soj ntsuam pom, undesirable tshua ntawm lub ntau yam nruab nrog cev thiab systems nyob rau hauv lub txais tos tshuaj tua kab mob "linezolid" feem ntau cuam tshuam rau lub paj hlwb thiab digestive systems. Hais txog 10% ntawm cov neeg mob thaum lub sij hawm kev kho mob muaj cai xeev siab thiab mob taub hau. Ib me ntsis tsawg txhawj xeeb txog lawv raws plab, kiv taub hau, thiab Candidiasis nyob rau hauv lub qhov ncauj mucosa.

Nyob rau hauv tas li ntawd, cov kws txawj taw tes qhia tawm xws li pliaj los ntawm cov tshuaj raws li peripheral neuropathy, qaug dab peg, nrig txog kev pom kev tsis taus (mus txog nws tag nrho tsis), thrombocytopenia, serotonin syndrome, angioedema thiab anaphylactic poob siab. Vim lub fact tias cov tshuaj yog tsuas yog siv nyob rau hauv lub tsev kho mob ib puag ncig, feem ntau loj heev txim yog zam.

Kev kho mob nyob undesirable tshua nyob rau ib feem ntawm symptomatic thiab tshuab. Kev tshem tawm ntawm cov tshuaj yog tau yog hais tias qhov heev ntawm sab los yog ib tug loj teeb meem tshaj tus kab mob no raug kho xam tau tias yog tshuaj tua kab mob.

Drug analogues "Linezolid"

Txawj nyeem ntawv tej zaum muaj ib lo lus nug txog seb tus "Linezolid" analogues ntawm cov tshuaj muaj. Ntawm cov hoob kawm, tus kws ua lag luam yog hais tias tsis tag nrho, nws muaj ib tug ob peb cov tshuaj uas zoo sib xws rau cov antimicrobial muaj pes tsawg leeg. Cov tshuaj txog Serb tshuaj tua kab mob "Zeniks" Norwegian "zyvox" thiab Israeli "Linezolid Teva". Muaj pes tsawg leeg ntawm tag nrho cov tshuaj raws li lub ntsiab active tshuaj muaj linezolid.

Puas muaj qhov sib txawv ntawm cov txhais tau tias thiab kev npaj "Linezolid" uas muaj npe saum toj no? Tus nqi ntawm cov tshuaj - uas yog lub ntsiab qhov txawv. Qhov tseeb yog hais tias muaj tib lub muaj pes tsawg leeg, cov tshuaj ua rau tib neeg lub cev nyob rau hauv raws nraim tib yam: tawm tsam nrog lub tib kab mob, ua rau cov tib phiv los yog cov tib contraindications. Tsis ntau sib txawv cov ntsiab lus thiab cov hau kev ntawm kev kho mob thiab ntau npaum.

Raws li ib tug txoj cai, qhov ntau kim mas analogues "Linezolid" tshuaj tua kab mob siv nyob rau hauv cov kev tshwm sim hais tias qhov no xyov tshuaj yog tsis tam sim no nyob rau hauv drugstores. Qhov no tshwm sim feem ntau, vim hais tias ntawm nws cov kev siv ntawm ib tug ntau ntawm cov neeg mob yog yuav luag tsis yooj yim sua vim tshuaj noj tshuaj thiab sib zog heev rau lub rhawv yuav tsis tau solved tsis muaj leej twg ntawm lub tsev muag tshuaj saw. Los ntawm no me me tog bookings tshuaj thiab, yog li ntawd, lub sijhawm ntawm ib co taw tes rau muag tag nrho nws cov Tshuag.

Tus nqi ntawm cov tshuaj

Lub medicaments ntawm lub oxazolidinone pab pawg neeg muaj ib tug nqi vim lub complex multistep synthesis ntawm cov tshuaj yeeb dej caw nyob rau hauv kws laboratories. Yuav ua li cas yog lub "Linezolid" tshuaj nqi? Ntsiav tshuaj (cov ntsiab lus ntawm lub ntsiab active tshuaj 600 mg, pob ntawm 10 daim) nyob rau hauv lub khw muag tshuaj chains yog tsawg kawg yog 18 txhiab. Cov nqi siab tshaj plaws ntawm no ntau npaum daim ntawv no yog 20 txhiab rubles ib 10 ntsiav tshuaj. Me ntsis cheaper yog cov tshuaj ntawm ib koob tshuaj ntawm 400 mg. Nws nqi yog hais txog 17-18 txhiab rubles rau 10 ntsiav tshuaj.

Cov tshuaj rau Txoj kev lis ntshav "Linezolid" koj yuav yuav ib tug me ntsis cheaper: pob ntawm 10 packets ntawm 100 ml yuav raug nqi 7.5-9 txhiab rubles, 10 packs ntawm 300 ml txhua - nyob rau hauv 15,3-16,2 txhiab rubles.

Cov kev npaj ntawm lub tib lub npe, uas yog npaum li cas pheej yig dua, feem ntau tig mus ua ib tug ntawv cuav thiab, nyob zoo, muaj tsis ntxim rau cov neeg mob lub cev. Cuaj kaum, qhov kev ncua nyob rau hauv txoj kev kho rau tus kab mob no, uas yuav pab tau tshem ntawm cov tshuaj tua kab mob 'Linezolid' nws tus kheej yog heev txaus ntshai. Yog vim li cas cov kws txawj pom zoo kom mus tau rau hauv lub tshuaj xwb nyob rau hauv pharmacies nrog ib tug zoo lub koob npe nrov.

Comments txog tshuaj tua kab mob "Linezolid"

Qhov chaw sib txawv yuav tsuj tsawg nrhiav kev xyuas txog cov tshuaj tua kab ntawm cov hoob kawm no. Qhov no siv tshwj xeeb rau cov lus qhia txog nws kev txais neeg kawm, cov neeg mob tau piav. Qhov no yog vim lub fact tias feem ntau ntawm cov neeg mob thaum lub sij hawm txoj kev kho muaj nyob rau hauv loj heev mob, thiab nco ntsoov tag nrho cov carry-rau pem hauv ntej ntawm koj lawv yog ib yam nyuaj heev.

Tshwj xeeb, nyob rau hauv lem, teb rau cov tshuaj "Linezolid" tsis tshua muaj zoo. Raws li lawv, cov tshuaj yog tau tiv nrog txawm lub feem ntau resistant cov kab mob. Lawv kuj taw tes kom paub tias qhov uas yuav muaj teeb meem vim kev phiv los sis overdose yog zoo nonexistent. Qhov no yog vim lub fact tias ib tug tshuaj tua kab mob yog tsuas yog siv nyob rau hauv tsev kho mob qhov chaw. Thaum tus thawj kos npe rau ntawm tsis haum los yog kev phiv tshuaj mus rau yeeb tshuaj yog nqa tawm tag nrho cov tsim nyog kho mob los mus tshem tawm lawv.

Yog li ntawd, peb ntsia tag nrho cov ntsiab lus ntawm cov tshuaj "linezolid". Cov lus qhia rau kev siv, cov nqi thiab tau tshuaj tshua tau piav nyob rau hauv daim ntawv no nyob rau hauv kom meej. Nws yuav tsum tau muab sau tseg tias, txawm tus nqi ntawm cov tshuaj, nws siv yog txhaum nyob rau hauv txhua txhua rooj plaub. Yuav kom txiav txim siab rau cov kev kho mob ntawm cov neeg mob cov tshuaj no ua tau tsuas yog tus kws kho mob.