Hypovarianism, Cov tsos mob thiab kev kho mob

Nyob rau hauv ntawm zes qe menyuam hypofunction txhais li cas soj ntsuam lub sij hawm uas muaj xws li cov kab mob uas txawv nyob rau hauv etiology thiab pathogenesis. Lawv tag nrho cov muaj zoo sib xws tej yam tshwm sim ntawm kev sib deev underdevelopment. Cov no muaj xws ntxiv lawm tshob, hypoplasia, amenorrhea, hypoestrogenism thiab malnutrition lub tsev me nyuam thiab zes qe menyuam.

Muaj ntau ntau hom thawj hypofunction. Thawj, thawj, kev soj ntsuam hauv daim ntawv ntawm cov teeb meem yog ntxov ntxov lawm. Feem ntau nws tshwm sim nyob rau hauv cov poj niam laus tshaj 35 xyoo. Lub etiology ntawm tus kab mob ua si ib tug loj luag hauj lwm ntau yam cov nyom ib puag ncig yam tseem ceeb. Ua kom muaj qhov teeb meem yuav ua tau ib tug kev tshuaj ntsuam genetic hloov, ib tug kev tshuaj ntsuam genetic predisposition, autoimmune ntshawv siab nyob rau hauv lub zes qe menyuam.

Ntawm zes qe menyuam hypofunction zaum yuav tshwm sim tiv thaiv ib tug tom qab ntawm tej coj khaub thiab generative zog. Nws manifests nws tus kheej nyob rau hauv daim ntawv ntawm cov kub flashes, amenorrhea, nce tawm hws, nkees, tsis muaj zog, mob nyob rau hauv lub plawv thiab lub taub hau, kom txhob muaj hauj lwm zoo. Thaum lub sij hawm tshwm sim ntawm tus mob txhais tau hais tias: txo me me ntawm lub ncauj tsev menyuam thiab zes qe menyuam, uas tsis muaj ntau ntawm estrogens thiab prolactin, tsis muaj hauv paus thiab daj lub cev, txhawb follicle stimulating thiab luteinizing cov tshuaj hormones rau hauv cov ntshav. Qhov no hypovarianism muaj xws kev kho mob: daim ntawv thov ntawm cov tshuaj hormones (tshuaj thiab cov tshuaj no-progestin). Lawm txoj kev kho zoo heev pab txoj kev mob ntawm cov neeg mob, yog li nyob rau hauv kev tsim kom muaj tus mob nws yog tsim nyog los pib kho mob tam sim ntawd.

Cais (secondary) hypovarianism, organic thiab haumxeeb mob ntawm hauj lwm ntawm lub hypothalamic-pituitary system yog ib qho tseem ceeb soj ntsuam ntaub ntawv xws teeb meem. Txawm tias muaj tseeb hais tias lub zes qe menyuam sau heev li qub xov tooj ntawm cov hauv paus, lawv tsis tshwm sim maturation txheej txheem. Rau xws li ib tug mob yus muaj los ntawm: malnutrition, thawj los sis theem nrab amenorrhea, uterine thiab ntawm zes qe menyuam hypoplasia, gipoestrogeniya. Qhov no hypovarianism feem ntau tshwm sim nyob rau hauv lub keeb kwm yav dhau ntawm lub cev cov ntsiab lus ntawm FSH thiab luteinizing hormone nyob rau hauv cov ntshav.

Muaj polycystic zes qe menyuam syndrome. Tus kab mob no muaj feem xyuam rau txog 3% ntawm cov tub ntxhais cov poj niam. Xws li ib tug teeb meem yus tshaj ntau lawm ntawm androgens (adrenal thiab zes qe menyuam), peripheral swb nyob rau hauv lawv cov metabolism. Nrog rau cov nta nws yog txiav txim ib tug nce tus nqi ntawm luteinizing hormone, ib txwm los yog tsis muaj ntau ntawm FSH, kom ntshav ntawm prolactin. Qhov no hypovarianism, cov tsos mob tsiag ntawv los ntawm txoj kev loj hlob pseudohermaphroditism, rau cov uas yus muaj los ntawm hyperandrogenism, clitoral hypertrophy, amenorrhea, ntxiv lawm tshob, anovulation thiab mob pob txuv.

Lwm yog vim li cas, uas tej zaum yuav tshwm sim vim hypofunction ntawm zes qe menyuam tej zaum yuav virilizing ntawm zes qe menyuam hlav. Pob hlwb nyob rau hauv lub zes qe menyuam tsim ntev li ntawm nqi ntawm testosterone, dehydroepiandrosterone thiab androstenedione, uas yog cov txiv neej nrog txiv neej pw cov tshuaj hormones. Soj ntsuam ces ntawm tus kab mob yog cov uas tsis muaj poj niam, cov lus ua poj niam meager (oligoopsomenoreya), acyclic uterine los ntshav. Tus kab mob yus muaj los ntawm cov tsos mob ntawm alopecia, hirsutism, deepening ntawm lub suab, tus tsim ntawm txiv neej lub cev hom, tus tsim ntawm pseudohermaphroditism, hypertrophy ntawm tus ple.

Yog hais tias muaj hypovarianism, kev kho mob yog muab tom qab ib tug kev daim ntawv ntsuam xyuas. Nyob rau hauv lub tsim ntawm cov qog nqa cov kws khomob, tawg thiab phais tshem tawm ntawm lub qog. Hormonal mob yuav kho tom qab ib tug meej kev soj ntsuam ntawm ntau yam tshuaj hormones.