Hypothalamic tso cov tshuaj hormones

Tso cov tshuaj hormones yog neeg neurohormone uas yog tsim hypothalamic nucleus. Lawv inhibit (statins) los yog tsim kho (liberiny) lawm Tropic pituitary cov tshuaj hormones. Nws activates lub endocrine qog, thiab muaj yog kev cai ntawm qhov kev tso tawm ntawm cov tshuaj hormones. Lub siab dua qhov chaw ntawm lub hauv paus poob siab system thiab endocrine system yog zoo txog vim hais tias ntawm lub tso cov tshuaj hormones.

hypothalamic muaj nuj nqi

Ib tug ntawm cov tseem ceeb Cheebtsam ntawm lub endocrine system lub luag hauj lwm rau zus tau tej cov tshuaj hormones - lub hypothalamus. Ua los ntawm cov hypothalamus tshuaj yog cov tshuaj hormones muab kev koom tes nyob rau hauv metabolic kev ntawm lub cev.

Nyob rau hauv lub hypothalamus muaj hlab ntsha hlwb kom zus tau tej cov tsim nyog yam hauv lub cev yuav tsum tau rau qub hauj lwm. Cov hlwb yog hu ua neurosecretory. Lawv ua hauj lwm - yuav tau txais pulses uas kis ntau qhov chaw ntawm lub paj hlwb. Rho tawm ntsiab tshwm sim los ntawm aksovazalnye synapses.

Ua los ntawm hypothalamic tso cov tshuaj hormones, los yog raws li lawv yog hu ua txawv, statins thiab liberiny, yog qhov tseem ceeb rau tej hauj lwm ntawm lub pituitary caj pas. Los ntawm lawv tshuaj xwm, lawv yog peptides. Vim tshuaj thiab paj impulses yog lawv synthesis, lawv thauj nyob rau hauv cov ntshav los ntawm tus pituitary hypothalamic-pituitary system.

kev faib ntawm cov tshuaj hormones

Xav txog cov feem ntau zoo-paub tso cov tshuaj hormones:

• Inhibiting lub tso pa tawm ntawm pituitary muaj nuj nqi - nws yog ib tug somatostatin melanostatin, prolaktostatine.
• Hom - peb yuav tau tham txog melanoliberine, prolaktoliberine, folliberine, lyuliberine, somatoliberin, thyrotropin-tso lawm, gonadotropin-tso lawm thiab corticotropin.

Cov tshuaj, los yog es ib co ntawm lawv, yuav roughly ua los ntawm lwm yam lub cev, tsis tsuas yog tus hypothalamus (e.g., pancreas).

Statins thiab liberiny

Cov hauj lwm ntawm lub pituitary caj pas yog ncaj qha nyob rau lawv. lawv kuj muaj ib feem nyob rau hauv lub hauj lwm ntawm lub peripheral endocrine qog:

• thyroid;
• zes qe menyuam nyob rau hauv cov ntxhais;
• noob qes hauv caug.

Statins thiab liberiny uas qhov zoo tshaj plaws lub npe hu yog:

• dopamine;
• GnRH (lyuliberin, folliberin);
• melonostatin;
• somatostatin;
• tireoliberin.

Lub secretion ntawm luteinizing hormone thiab follicle-stimulating hormones ntawm lub pituitary GnRH muab.

Nyob rau cov kev ua ntawm androgen nyob rau hauv cov txiv neej kuj muaj kev cuam tshuam GnRH, ua rau kom ib qho kev nce ntawm cov phev ua si thiab cov theem ntawm libido.

Thiab cov poj niam neurohormone lub luag hauj lwm rau lub cev ntas, tus nqi ntawm cov tshuaj hormones txawv nrog lub sij hawm ntawm lub voj voog nws.

Tsis txaus zus tau tej cov tso cov tshuaj hormones feem ntau ua rau ntxiv lawm tshob thiab impotence.

Cov yam ntxwv ntawm cov tshuaj hormones

Corticotropin lawm lub luag hauj lwm rau txoj kev xav ntawm kev ntxhov siab vim, ua los ntawm cov hypothalamus. Qhov no yog yam tseem ceeb heev tso tau, kuj nyob rau hauv nrog cov pituitary cov tshuaj hormones thiab lawv cov teebmeem rau lub adrenal qog. Cov neeg uas muaj ib tug tsis muaj no lawm feem ntau txom nyem los ntawm tawg, thiab adrenal insufficiency.

GnRH - ib yam tshuaj uas pab tau ntau lawm ntawm gonadotropins - kuj yog ib tug cov khoom ntawm lub hypothalamus. Nws tseem hu ua gonadotropin-tso lawm.

Lub cev tau hauj lwm ntawm kev ua me nyuam kabmob ua tsis tau tsis GnRH. Nws yog qhov no lawm yog lub luag hauj lwm rau lub ntuj kawg ntawm lub cev ntas rau cov poj niam. Nrog nws koom tes yuav siv sij hawm muab cov txheej txheem ntawm maturation thiab tso tawm ntawm lub qe. Qhov no lawm yog lub luag hauj lwm rau libido (pw ua ke tsav). Thaum muaj tsis txaus zus tau tej cov tshuaj los ntawm lub hypothalamus nyob rau hauv cov poj niam feem ntau tsim ntxiv lawm tshob. Yuav ua li cas lwm tus muaj tso cov tshuaj hormones?

somatoliberin

Feem ntau cov sai tso tawm rau hauv thaum yau thiab thaum tiav hluas. Nws lub ntsiab feature yog tus txheej txheem ntawm normalization ntawm hloov khoom nruab nrog txoj kev loj hlob thiab lub cev tshuab. Los ntawm nws cov nyob rau hauv tag nrho cov kev loj hlob thiab tsim ntawm tus me nyuam. Tsis txaus zus tau tej cov tshuaj los ntawm lub hypothalamus yuav ua tau kom dwarfism (dwarfism).

Prolaktoliberin

Nws feem ntau active kev loj hlob tshwm sim thaum lub sij hawm hnub thiab thoob plaws hauv lub noj lub sij hawm ntawm tus me nyuam niam. Qhov no tso tau normalizes zus tau tej cov prolactin, txoj kev ducts ntawm lub mammary qog.

Prolaktostatin

Prolaktostatin hais txog ib tug subclass ntawm statins ua los ntawm cov hypothalamus, yog lub luag hauj lwm rau lub inhibition ntawm prolactin.

Los ntawm prolaktostatinam muaj xws li:

· Dopamine;

· Somatostatin;

· Melanostatin.

Lawv lub ntsiab txiav txim yog aimed ntawm suppressing Tropic cov tshuaj hormones ntawm lub pituitary thiab hypothalamus.

Melanotropin-tso lawm

Nyob rau hauv tus txheej txheem ntawm melanin xim thiab sib cais ntawm lub hlwb muaj feem xyuam rau melanoliberin. Nws kuj ua rau lub ntsiab ntawm lub DWP pituitary.

Influences neurophysiological tus cwj pwm. Nws yog siv rau tshem cov kev kho mob ntawm depressive lub xeev thiab parkinsonism.

Thyrotropin-tso lawm (TRH)

Los ntawm thyrotropin-tso cov tshuaj hormones ntawm lub hypothalamus kuj siv thyroliberine. Nws yeej txhawb zus tau tej cov tshuaj hormones ntawm lub anterior pituitary thyritropic.

Yuav kom ib tug me me raws li influences tus txheej txheem ntawm prolactin. Thyroliberine tej lub concentration ntawm thyroxine nyob rau hauv cov ntshav.

Cns muaj ib lub zog txhawb rau cov txheej txheem ntawm zus tau tej cov tshuaj hormones. Zus tau tej cov neurohormones yog lub luag hauj lwm neurosecretory cell ntxawg system.

Yooj yim zog liberinov

Qhov no hypothalamic tso cov tshuaj hormones. Ua ntxawg zog. GnRH normalize hauj lwm ntawm lub tsev me nyuam system ntawm cov poj niam thiab cov txiv neej.

Lawv yog cov luag hauj lwm rau lub tu tub tu kiv ntawm follicle-stimulating lawm thiab muaj feem xyuam rau lub lag luam ntawm lub noob qes thiab zes qe menyuam.

Tej tivthaiv raws li lyuliberin, renders txiag ntxim rau ovulation, txoj kev ua tau me nyuam hauv plab conception.

Cov poj niam uas yog tsis muaj ab tsi mus rau lub intimate lub neej, thiab lyuliberin folliberin ua nyob rau hauv tsis txaus ntau.

Muaj kuj tso yam hais txog qhov nruab nrab feem ntawm cov hypothalamus, tab sis lawv cov kev twb kev txuas mus rau lub pituitary anterior pituitary hlwb thiab tsis tau kawm.

Agonists tso lawm tshuaj

Raws li twb tau sau tseg, cov tshuaj hormones los ntawm cov hypothalamus. Thaum nws yog qhov kev kawm rau tsim kho lub zes qe menyuam, rau piv txwv ua ntej IVF txoj kev, siv agonists los yog corticotropin tso lawm analogs. Hais tias yog, lawv muaj nyob rau hauv lub cev cov nyhuv tib yam li nws tus kheej lawm.

Tab sis qhov muaj feem ntawm kev phiv tshuaj nyob rau ib feem ntawm tus poj niam lub cev. Qhov no tshwm sim vim qis tshuaj no ntau ntau. Cov feem ntau los muaj xws li:

• mob taub hau;
• tawm fws;
• kub flashes;
• paum dryness;
• mus ob peb vas swings;
• kev nyuaj siab.

Tshuaj yog siv raws li nram no:

• "Diferelin" yog ib tug dag decapeptide analogue ntawm lub ntuj lawm tso.
• "Dekapeptil" raws li ib feem ntawm ib tug triptorelin, ib co analogue ntawm GnRH. Lub ib nrab-lub neej ntev. Feem ntau siv rau dag insemination.
• "Lyukrin depot" - leuprorelin. Nws muaj anti-tshuaj, anti-androgenic nyhuv, kho endometriosis, hormone-dependent hlav - cancer ntawm lub prostate, uterine fibroids. "Lyukrin depot" thiaj li muaj cov concentration ntawm testosterone rau cov txiv neej, estradiol nyob rau hauv cov poj niam, nyob rau hauv tas li ntawd, cheeb incretia pituitary FSH, LH.
• Nyhuv ntawm cov tshuaj maj restores cov physiological secretion ntawm cov tshuaj hormones.
• 'Zoladex' - hluavtaws analogue ntawm ib tug tej yam tshuaj-tso lawm (LH). Feem ntau siv nyob rau hauv IVF. Thiaj li muaj cov concentration ntawm estradiol nyob rau hauv cov ntshav, qhov no tshwm sim vim hais tias ntawm hluav ntawm LH secretion ntawm anterior pituitary.
  

Peb tau sib tham txog kev npaj agonists tso lawm.

antagonists

Txij thaum tau txais tso lawm agonists qab heev estradiol zaum yuav tshwm sim sai tso tawm ntawm luteinizing hormone. Qhov no ua rau ntxov ntxov ovulation thiab kev puas tsuaj ntawm lub qe. Kom tsis txhob no, lub antagonists tso lawm siv. Raws li ib tug tshwm sim ntawm lawv ua tau tsim kho lub pituitary caj pas dua. Ntawm zes qe menyuam hyperstimulation syndrome tsis manifest nws tus kheej, tab sis nws yog li ntawd feem ntau rooj plaub vim lub caij nyoog siv GnRH agonists. Yog muab tsis pub dhau tsib hnub los ntawm qhov pib ntawm daim ntawv thov ntawm follicle stimulating lawm.

Yuav kom kho yog muaj kev vam meej, tag nrho cov hom phiaj npaj yuav tsum tau tsuas yog ib tug tshwj xeeb.