"Endoxane": cov lus qhia rau kev siv, tiag tiag counterparts, lub chaw tsim tshuaj paus

Tshuaj "endoxane" yog hais txog ib tug pab pawg neeg ntawm anti-mob cov neeg ua hauj. Nyob rau hauv daim ntawv ntawm tso tawm nws yuav tau muab los siv lus los yog parenterally. Yuav ua li cas hom tshuaj taw thiab nyob rau hauv dab tsi ntau npaum, daws tsuas tus kws kho mob rau lub hauv paus ntawm lub sij tshwm sim ntawm tus neeg mob tus mob.

Muaj pes tsawg leeg thiab thaj chaw ntawm cov tshuaj

Lub ntsiab active ingredient ntawm cov tshuaj "endoxane" cov lus qhia rau kev siv hais txog cyclophosphamide. Ib tug ntsiav tshuaj muaj 50 mg ntawm nws. Cov tshuaj hais txog ib tug pab pawg neeg ntawm antitumor tshuaj thiab yog ib tug biconcave ntsiav tshuaj nrog ib tug dawb lub hnab ntawv thiab cov tub ntxhais ntawm lub tib lub Hawj txawm. Raws li ntxiv Cheebtsam active kws khoom muaj calcium carbonate thiab hydrogen phosphate, sodium karamellozu, glycerol, gelatin, lactose, pob kws starch, macrogol, magnesium stearate, polysorbate, sucrose, talc, silica thiab titanium.

Yuav ua li cas yog lub pharmacology ntawm cov tshuaj?

Lub ntsiab active tshuaj yeeb tshuaj, namely cyclophosphamide, alkylating thiab muaj cytostatic nyhuv. Los ntawm cov xwm, nws yog ze rau mustard roj, nitrogen ua nws analogue.

Lub mechanism ntawm qhov kev txiav txim ntawm cyclophosphamide raws li nyob rau hauv lub tsim ntawm crosslinks ntawm DNA molecules thiab RNA thiab protein synthesis suppressing lub cev.

Cov tshuaj ntawm cov tshuaj

Lub ntsiab active ingredient "endoxane" cov tshuaj muaj yuav luag tiav degree ntawm absorbability los ntawm cov hnyuv ib ntsuj av. Nws concentration hauv cov ntshav tom qab qhov ncauj thiab tso dej thawj coj yog tib yam. Cyclophosphamide metabolism tshwm sim feem ntau nyob rau hauv lub siab, nyob qhov twg nyob rau hauv tus ntawm microsomal oxidase mechanism yog lub tsim ntawm active alkylating metabolites. Ib txhia ntawm lawv yog hloov dua siab tshiab rau hauv tsaug zog cov ntaub ntawv, lwm pab pawg neeg tsiv mus rau lub hlwb, qhov chaw uas lub enzymatic kev txiav txim ntawm phosphatases transformed rau hauv tshuaj nrog cytotoxic zog.

Lub degree ntawm thwj toob ntawm tus thawj hauv daim ntawv ntawm cov tshuaj noj ntshav cov nqaijrog yog negligible thiab yog 12-14%. Txawm li cas los, tib qib ntawm metabolites twb sib npaug 60%.

cyclophosphamide ua los ntawm lub raum feem feem ntau nyob rau hauv daim ntawv ntawm metabolites. Kwv yees li 5-25% ntawm cov tshuaj yog tas nyob rau hauv nws thawj daim ntawv nyob rau hauv cov zis thiab bile.

Parameter T1 / 2 nyob rau hauv cov tshuaj sib npaug 7 teev rau cov neeg laus thiab 4 teev rau cov me nyuam.

Nyob rau hauv dab tsi koob noj cov tshuaj?

Tshuaj "endoxane" nyob rau hauv cov ntsiav tshuaj daim ntawv coj lus ua ntej noj mov los yog ib nrab ib teev tom qab noj mov, tom qab 2 teev.

Vim lub fact tias cov kws khoom muaj nyob rau hauv lub loj tus naj npawb ntawm chemotherapeutic kiag, cov kev xaiv hom kev saib xyuas thiab ntau npaum tus kws kho mob pom tias ib lub zuj zus.

"Endoxan" - ntsiav tshuaj - phau ntawv kom ntau npaum 1-3 mg / kg lub cev hnyav ib hnub twg, uas tej zaum yuav tsum yog los ntawm 50 mus rau 200 mg cyclophosphamide rau 24 teev. Lub caij ntawm kev kho mob yog 2-3 lub lim piam.

Yog hais tias cov tshuaj yog noj ua ke nrog lwm yam tshuaj uas muaj anti-mob zog, ntau npaum ntawm tag nrho cov ntsiab ntawm txoj kev kho undergoes kho.

Yeej yuav muaj ib tug overdose?

Lub xub ntiag ntawm ib lub antidote nyob rau hauv cov kev npaj "endoxane cov lus qhia rau kev siv yog tsis paub tseeb hais tias. Nyob rau hauv cov ntaub ntawv ntawm tau siab tshaj lub yam koob tshuaj pom zoo rau cov txij nkawm kho raws li tsim nyog kho mob ntawm kis kab mob, ntsoos ntsoos cov tsos mob cardiotoxicity thiab myelosuppression tshem tawm.

Raws li ib tug tshuaj ua ke nrog lwm yam tshuaj?

Yog hais tias tus neeg mob yuav siv sij hawm cov txhais tau tias provoking microsomal oxidation nyob rau hauv lub siab, ces lub neej coj kev kho mob nrog rau cov tshuaj "endoxan" qhia hais nce synthesis ntawm metabolites nrog alkylating kev ua si, tsis yog ib nrab-lub neej ntawm cyclophosphamide thiab ua rau kom nws cov efficiency.

Qhov no tshuaj cheeb cholinesterase kev ua si thiab metabolic pathway yeeb, nce nws toxicity, thiab tsub kom lub efficiency ntawm suxamethonium.

Yog hais tias "endoxane" siv nyob rau hauv ua ke nrog "Allopurinol" uas muaj yog nce nws tsis zoo los rau tus hlwb pob txha.

Nyob rau hauv cov ntaub ntawv ntawm simultaneous kev kho mob nrog cyclophosphamide, colchicine, probenecid, sulfinpyrazone tus kws kho mob feem ntau corrects KOOB anti-gout tshuaj. Qhov no yog txuam nrog kev raug mob ntawm nephropathy nyob rau hauv ib tug sib koom daim ntawv thov "endoxane" nrog uricosuric tshuaj.

Cyclophosphamide thiaj synthesis yam nyob rau hauv lub siab, yog lub luag hauj lwm rau cov ntshav txhaws thiab platelet ntau lawm, txawm li cas los, thaum kho mob nrog anticoagulants txo kev ua si ntawm lub yav tas.

Cov neeg mob noj cov tshuaj "endoxan" phau ntawv qhia kom noj cov zaub mov tsis suav txiv kab ntxwv qaub kua txiv, txij li thaum nws muaj yam uas ua txhaum cov kev ua kom tau zoo thiab lub ntsiab active khoom sib ua zaub mov ntawm lub medicament.

Thaum pa roj carbon monoxide-xeem nrog cyclophosphamide "Doxorubicin" los yog "daunorubicin" yog amplified cardiotoxic los ntawm cov tshuaj no.

Thaum lawv tseem nrog rau lwm yam immunosuppressants, xws li "Azathioprine" "Tacrolimus", "Chlorambucil", "SSC", "Merkapturin" ua rau ib qho kev nce nyob rau hauv qhov tshwm sim ntawm ob kab mob thiab qog hom.

Nyob rau hauv cov ntaub ntawv ntawm kev sib koom siv "endoxane" thiab "Lovastina" nyob rau hauv cov neeg mob uas lub plawv sib hloov tej zaum yuav cov kev pheej hmoo ntawm rhabdomyolysis thiab lub raum tsis ua hauj lwm nyob rau hauv ib tug mob daim ntawv.

Yog hais tias kev kho mob nrog cyclophosphamide ua ke nrog mielosupressantami los yog nrog tawg txoj kev kho, yog nws ua tau mus nce ugneeniya hlwb pob txha muaj nuj nqi.

Tib mus txais tos "endoxan" nrog high-koob cytarabine thaum lub sij hawm rau kev npaj mus manipulations rau hlwb pob txha hloov tsub kom cov xwm txheej ntawm neeg tuag taus cardiomyopathy.

Yuav ua li cas puas cov tshuaj no rau lub tsev me nyuam muaj nuj nqi?

Tshuaj "endoxane" neeg mob testimonials ua pov thawj nws, yuav ntxias sterility nyob rau hauv cov neeg mob ntawm ob sexes, uas tej zaum yuav irreversible.

Nyob rau hauv Feem ntau, cov poj niam amenorrhea tshwm sim, tab sis coj khaub regularity feem ntau rov qab nyob rau hauv ib ob peb lub hlis tom qab kev kho mob nrog cyclophosphamide. Yog hais tias txoj kev kho tau nqa tawm nyob rau hauv prepubertal ntxhais, hloov nyob rau hauv txoj kev loj hlob ntawm ob kev sib deev ces muaj cai. Ua poj niam ib txwm, fertility tau ploj lawm.

Nyob rau hauv cov kev kho mob ntawm cov txiv neej cov tshuaj "endoxane" qhia hais tias nyob rau hauv tej rooj plaub raug qhia azoospermia los yog oligospermia. Qhov no yog vim lub zog zus tau tej gonadotropins ntawm ib tus nqi ntawm testosterone tso tawm. libido theem thiab potency nyob rau hauv cov txiv neej yog tsis txo. Yog hais tias kev kho mob nrog cyclophosphamide ua nyob rau hauv prepubertal cov tub hluas, lub obazovanie theem nrab kev sib deev ces muaj tshwm sim feem ntau. Txawm li cas los, tus neeg mob ntawm azoospermia, oligospermia thiab kev txhim kho ntawm gonadotropins tau sau tseg. Nws tseem yuav tshwm sim testicular Atrophy. Nws yog ib nqi sau cia hais tias lub azoospermia yog reversible, txawm hais tias tus rov qab los ntawm lub zog yuav tshwm sim nyob rau hauv ib ob peb xyoos tom qab qhov kawg ntawm kev kho mob.

Yuav ua li cas yog cov kev phiv los ntawm ib tug yeeb tshuaj?

Noj tshuaj "endoxane cov lus qhia rau kev siv yog paub tseeb hais tias, tej zaum nws yuav ua rau ib txhia mob ntawm lub hemopoietic system:

• Leukopenia, neutropenia - feem ntau heev.
• Tsawg ntau yog anemia thiab thrombocytopenia.

Tom qab 1-2 lub lis piam los ntawm thaum pib ntawm kev kho mob, tus neeg mob qhia lub siab tshaj plaws yuav txo tau ntawm leukocytes thiab platelets nyob rau hauv cov ntshav. Cov tsis raug txum tim rov los li qub tsis pub dhau 7-10 hnub los ntawm qhov kawg ntawm txoj kev kho.

Nyob rau hauv cov kev kho mob nrog cyclophosphamide yuav ua sab tshua ntawm tus mob huam:

• Xeev siab thiab ntuav.
• Anorekisya.
• Stomatitis.
• Mob nyob rau hauv lub plab cheeb tsam.
• Quav irregularities.
• Daj ntseg.
• Hemorrhagic mob plab.

Feem ntau yeej tsis tshwm sim siab kawg txuam nrog nce ua si ntawm enzymes thiab bilirubin theem sawv. Heev ib tug loj pawg ntawm cov neeg mob uas muaj aplastic anemia thiab tau txais high-koob tshuaj "endoxane" los yog combining nws nrog busulfan, hais tias endoflebit hepatic leeg. Qhov no tshwm sim yuav tshwm sim 1-3 lub lis piam tom qab hloov hlwb pob txha hloov thiab yog manifested nyob rau hauv ib tug ntse nce nyob rau hauv lub cev loj, ascites, hepatomegaly thiab hyperbilirubinemia, hepatic encephalopathy.

Ua ntej cov tshuaj yuav ua rau undesirable tshua nrog daim tawv nqaij:

• Reversible alopecia.
• Pob.
• Lub pigmentation ntawm daim tawv nqaij thiab cov rau tes.

Nws kuj yuav txhais los ntawm ib tug ua txhaum ntawm lub urinary system nyob rau hauv cov kev kho mob ntawm cov tshuaj "endoxane". Cov lus qhia, xyuas ntawm cov kws kho mob thiab cov neeg mob yuav qhia tau ntau lub xeev:

• Cystitis ua ke nrog fibrosis zais zis (los yog tsis muaj nws).
• Hemorrhagic urethritis.
• Necrotic phenomena tubule mus txog thaum tuag.

Nyob rau hauv cov zis, cov neeg mob tej zaum yuav kuaj tau los ntawm lub epithelium ntawm lub urinary zis. Yog hais tias daim ntawv ntawm hemorrhagic cystitis hnyav, tsis txhob noj cov tshuaj. Qhov zoo tshaj plaws kev tiv thaiv ntawm tus mob no yog cov tshuaj "Mesna". Yog hais tias "endoxan" koob tshuaj ntau zog, muaj peev xwm tsim lub raum tsis ua hauj lwm raws li nephropathy thiab giperurekemii.

Yog hais tias tus neeg mob muaj ib tug loj heev degree ntawm tiv thaiv, ces cov kev kho mob ntawm cyclophosphamide tej zaum yuav muaj mob loj heev mob.

Tsis tas li ntawd muaj peev xwm tsim cov nram qab no tshwm sim tsis zoo:

• Cardiotoxicity (high koob tshuaj), mob degree ntawm lub plawv tsis ua hauj lwm.
• Koj muaj teebmeem kev fibrosis, interstitial xwm.
• Cuam tshuam spermatogenesis thiab oogenesis, reversible thiab irreversible sterility.
• Txoj kev loj hlob ntawm ob phem neoplasms xws li mob cancer ntawm lub zais zis, mieloproliferatsiya thiab lymphoproliferation.
• Kev tsis haum tshuaj raws li pob, khaus, urticaria, tej zaum nyob rau hauv daim ntawv ntawm ib tug anaphylactic cov tshuaj tiv thaiv.
• Tsis mob zoo.
• Ntawm lub ntsej muag yaug kais dej, tawm hws, mob taub hau.

Lub hav zoov ntawm kev phiv loj heev los ntawm kev noj cov tshuaj yog ib txwm seb puas tsimnyog tau rau lo lus nug hais txog cov tau cov kev pab cuam tiv thaiv tau txaus ntshai rau tus neeg mob.

Uas kab mob muab cov tshuaj no?

Ntsiav tshuaj "endoxan" tej zaum yuav raug muab tso rau tus neeg mob yog hais tias nws muaj cov nram qab cov kab mob:

• Hodgkin tus kab mob.
• Ntau myeloma.
• Tus mob cancer mis.
• Lymphoblastic nqaij hlav nyob rau hauv mob los yog mob daim ntawv.
• Tsis-Hodgkin lymphomas hom.
• Retinoblastoma.
• Neuroblastoma.
• Mycosis gribkovidnogo cim.

Nws qhia lub ibqho ntawm daim ntawv thov nyob rau hauv lub complex anticancer txoj kev kho daim ntawv mus rau yeeb tshuaj "endoxane" kev qhia ntawv. Cov chaw tsim tshuaj paus xav hais tias nws muaj xws li nyob rau hauv cov kev kho mob ntawm ncauj tsev menyuam thiab lub zais zis mob cancer, mob ntsws cancer thiab prostate cancer, sarcomas thiab reticulosarcoma, cov kab mob Ewing thiab Wilms.

Cov tshuaj cyclophosphamide-raws li yuav siv tau raws li immunosuppressant hnyav autoimmune kab mob xws li, psoriatic thiab mob caj dab rheumatoid, haemolytic anemia, collagen kab mob, nephrotic syndrome, raws li zoo raws li kom tsis txhob graft rejection.

Thaum cov tshuaj yog txhob?

Lub medicament "endoxan" muaj ib tug luj contraindications, xws li:

• Cev xeeb tub thiab lactation.
• Cystitis.
• Cov kab mob nyob rau hauv lub active daim ntawv.
• Kev ua txhaum ntawm pob txha tsim muaj hauj lwm cov lus hais daim ntawv no.
• Lub xub ntiag ntawm npau taws me ntsis rau qhov yooj yim thiab ntxiv cov tshuaj tshuaj.
• urinary tuav tseg.

Tshwj xeeb kev kho mob cov kws kho mob muab cov tshuaj nyob rau hauv cov kab mob ntawm lub plawv, lub raum thiab lub siab, loj heev, gout, adrenalectomy, lub xub ntiag ntawm infiltration dab nyob rau hauv lub hlwb pob txha, nefrourolitiaze.

Cov kev taw qhia nyob rau hauv cov kev kho mob ntawm

Thaum lub sij hawm haus "endoxan" raug mus rau lub obligatory tswj ntshav (qe thiab platelet suav) thiab zis (lub xub ntiag ntawm cov ntshav liab) ntawm ib tug neeg mob.

nws yog pom zoo yuav tsum txhob muab kev kho mob "endoxane" txhais tau tias nyob rau hauv tej rooj plaub. Cov lus qhia rau kev siv cov tshuaj pom zoo kom ua li ntawd nyob rau hauv cov nram no tej yam kev mob:

• Manifestation ntsuas cystitis.
• Tej lub concentration ntawm leukocytes thiab platelets mus rau lub tseem ceeb heev qhov tseem ceeb.
• Tshwm sim ntawm kab mob (koob tshuaj kho yog tau).

Yog hais tias "endoxane" yog siv nyob rau hauv siab koob, tus neeg mob yog tshuaj, "Meena" rau kev tiv thaiv ntawm hemorrhagic cystitis hom.

Nyob rau hauv cov kev kho mob nrog cov tshuaj no yuav tsum caiv txhob haus cawv thiab siv txhim khu kev qha txoj kev pov.

Yog hais tias tus neeg mob yog muab "endoxan" rau 10 hnub tom qab phais nrog ua kom tsaug zog, lub anesthesiologist yog paub txog qhov no.

Tom qab adrenalectomy ua ib koob tshuaj hloov "endoxane" thiab lwm yam tshuaj corticosteroids.

tshuaj analogues

Yog hais tias muaj yeej loj heev contraindications thiab txaus ntshai, ces muaj li cas muab li noj cov tshuaj "endoxane" kev qhia ntawv. Analogs yuav tshuaj los ntawm ib tug kws kho mob raws li ib tug haum lwm. Cov lawv:

• "Ledoksin".
• "Cyclophosphamide".
• "Cytoxan."
• "Cyclophosphamide - Teva".
• "Cyclophosphamide -Lens".
• "Endoxane - Astana".

Cov ntaub ntawv no yog ib tug yooj yim to taub version ntawm cov lus qhia mus rau yeeb tshuaj "endoxane". Lub hom phiaj ntawm cov tshuaj no yog ua tau tsuas yog los ntawm cov kws kho mob.