Cov tshuaj "Aspekard": cov lus qhia rau kev siv, analogs, xyuas

Acetylsalicylic acid (ASA) yog hais txog cov tshuaj nrog antipyretic, anti-inflammatory thiab antiplatelet los. Nyob rau hauv kev kho mob xyaum nws yog siv ntau tshaj 125 xyoo, vim hais tias yog ib qho ntawm feem kawm tshuaj. Wherein ASA yog tam sim no muaj raws li ib tug kardioformy los txo txoj kev pheej hmoo ntawm coronary artery thrombosis, uas hinders lub kev loj hlob ntawm myocardial infarction. Ib tug raug piv txwv yog lub npaj "Aspekard" uas muaj acetylsalicylic acid nyob rau hauv ib koob tshuaj noj rau antiplatelet nyhuv.

Cov ntaub ntawv nyob rau hauv qhov kev tso tawm daim ntawv thiab Chaw tsim tshuaj paus

Cov chaw tsim tshuaj paus ntawm cov tshuaj yog cov Ukrainian lub tuam txhab "Stirolbiopharm". Raws li, qhov raug technology siv, ua nyob rau hauv daim ntawv zheludochnorastvorimoy ntaub ntawv ntawm ib koob tshuaj ntawm 100 mg rau ib ntsiav tshuaj. Txoj kev ntsiav tshuaj layout:

• Thawv 120 ntsiav tshuaj (10 mus rau 12 hlwv tab.);
• polymeric thawv 100 ntsiav tshuaj.

Ntsiav tshuaj "Aspekard" muaj 100 mg ntawm ASA, microcrystalline cellulose, croscarmellose sodium, colloidal silicon dioxide, stearic acid.

Pom zoo rau lub sij hawm

Nyob rau hauv kev npaj "Aspekard" daim ntawv thov kev nqaim txaus, txawm hais tias nws muaj cov lus qhia rau cov tswv yim rau kev kho mob ntawm ntau cov kab mob, nrog rau rheumatic kab mob. Chaw tsim tshuaj paus pom zoo "Aspekard" thiab raws li ib antipyretic neeg sawv cev los yog analgesic. Nyob rau hauv qhov tseeb, nyob rau hauv ntau npaum ntawm acetylsalicylic acid tshuaj yuav tsuas yuav zoo siv raws li ib tug tshuaj uas tiv thaiv platelet aggregation.

Indications "Aspekard"

Nyob rau hauv kev npaj "Aspekard" qhia ntawv nyob rau daim ntawv thov, xyuas tshawb fawb soj ntsuam cov tub txawg thiab muab ib tug ntau ntawm cov ntaub ntawv muaj feem xyuam rau antiplatelet txoj kev kho. Nws yog qhia nyob rau hauv lub nram qab no:

• thaum (ACS), mob coronary syndrome (ntawm kauj ruam mob nce myocardial infarction, kev nyuaj siab los yog lawm ST ya qhov chaw, nyob rau hauv tsis ruaj tsis khov angina);
• nrog stroke (ischemic stroke los yog nraum ischemic nres);
• nyob rau hauv cov ntaub ntawv ntawm cov pov thawj coronary artery kab mob raws li ib tug txhais tau tias ntawm kev tiv thaiv ntawm mob coronary syndrome thiab mob stroke;
• nyob rau hauv cov kev tiv thaiv ntawm recurrent lub sijhawm uas nws mob coronary syndrome thiab mob stroke;
• nrog lub xub ntiag ntawm varicose leeg;
• raws li ib tug tiv thaiv kev neeg sawv cev, ib tug ceeb toom shunt thrombosis tom qab CABG;
• uas kub siab nyob rau hauv cov ntaub ntawv ntawm ib tug siab mob plawv.

High mob plawv yog ib qho ua ib pawg tswvyim uas muaj xws li lub xub ntiag ntawm lub hom phiaj hloov khoom nruab nrog kev puas tsuaj nyob rau hauv tawg thiab lwm yam kab mob: ntshav qab zib mellitus, coronary artery kab mob, TSVB.

Nta ntau npaum kiag pom zoo los ntawm lub chaw tsim tshuaj paus

Nyob rau hauv kev npaj "Aspekard" tsim kom muaj kev qhia ntawv yog tsis tseem ceeb coj noj coj ua ntawm tus neeg mob txoj kev kho mob. Nws muaj cov lus qhia txog lub koom haum saib xyuas ntawm cov tshuaj nyob rau hauv txawv kev soj ntsuam lub sijhawm xws li los ntawm cov kev tiv thaiv ntawm atherothrombotic txheej xwm nyob rau hauv CHD thiab TSVB thiab xaus nrog mob mob ntawm cerebral ncig thiab lub plawv. Qhov no omission yog suav tias yog tsis tau saib xyuas thiab unprofessional cwj pwm rau qhov teeb meem ntawm cov tshuaj thiab lawv nrog cov lus qhia cov ntaub ntawv. Nws kuj tsim lub preconditions rau loj ntawv ntawm cov khoom nyob rau hauv uas pom zoo noj tshuaj npaum cas txawv.

Dosing kiag rau lub hauv paus ntawm thoob ntiaj teb cov tswv yim

Nyob rau lub hauv paus ntawm thoob ntiaj teb raws li kev cai tsim los ntawm cov European Community of Cardiology (ESC) thiab cov American Heart Association (Aha) thiab txais tau los ntawm Ministry of Health, lub hom ntawm daim ntawv thov ntawm acetylsalicylic acid yog raws li nram no:

• nyob rau hauv kauj ruam thaum muaj xwm ceev thaum lub sij hawm mob coronary syndrome yuav tsum muab tus neeg mob yuav zom cov ntsiav tshuaj 3 "Aspekard 100". Cov lus qhia rau kev siv yog ignored, thiab ib koob tshuaj ntawm 300 mg;
• mob mob ischemia (CHD) nyob rau hauv qhov kev txais tos muab ib ntsiav tshuaj ntawm 100 mg nyob rau hauv rau yav tsaus ntuj tom qab noj hmo;
• nrog tawg neeg mob muaj ib tug yuav muaj mob plawv mob, raws li tau zoo raws li venous varicose lossi txais yuav los ntawm 100 mg (1 ntsiav tshuaj) nyob rau hauv rau yav tsaus ntuj tom qab noj hmo.

Lwm txoj hau kev tshuaj thawj coj "Aspekard" qhia ESC thiab Aha tsis muab. Nws tseem ceeb heev kom nco ntsoov hais tias tus txheej txheem koob "Aspekard" yog 100 mg ntawm ASA. Rau kev tiv thaiv ntawm cov saum toj no cov kab mob, nyob rau hauv raws li cov lus qhia ESC thiab Aha, thov koob tshuaj ntawm 75 mg. Txawm li cas los, 100 mg muab cov neeg mob tom qab CABG los mus tiv thaiv thrombosis ntawm lub shunt. Nyob rau hauv lwm tus neeg mob nws pom zoo kom thov 75 mg, i.e. tus nqi ntawm cov ASA, uas muab txaus antiplatelet nyhuv thiab muaj ib tug tsawg kawg nkaus uas yuav muaj gastrotoxicity.

Tsis tas li ntawd, cov chaw tsim tshuaj paus tsis muaj ntaub ntawv tseem ceeb nyob rau hauv lub abolition ntawm cov tshuaj. Raws li statistics, cia li cessation ntawm qhov ua rau ntawm 10.2% ntawm cov mob plawv txheej xwm. Thiab lawv muaj nyob tom qab kwv yees li 10.6 hnub ntawm lub hnub tim ntawm tshem tawm ntawm ASA. Qhov no lub sij hawm yog ib qho nruab nrab thiab qhia lub sij hawm nyob rau hauv uas tag nrho cov pejxeem yog txo platelet cyclooxygenase tau hauj lwm. Raws li ib tug tshwm sim, tau ntawm cov ntshav txhaws rov qab los. Vim hais tias cov tshuaj yuav tsum tau noj tsis tu ncua, thaum lub sij hawm lub sij hawm ntawm lwm antiplatelet neeg sawv cev es tsis txhob "Aspekard" tsos ntawm cov teeb meem los ntawm tus mob huam yog yuav tsum tau.

Contraindications "Aspekard" npaj

Txoj kev nyab xeeb ntawm tag nrho cov kws tshuaj yog txheeb ze, vim hais tias lawv muaj kev phiv. Nyob rau tib lub sij hawm lawv ua rau ib txhia contraindications. Nyob rau hauv kev:

• nyob rau hauv mob ntawm cov ntshav coagulation (hemorrhagic diathesis, hemophilia A thiab B);
• nyob rau hauv mob ntawm lub plab nta (erosions, mob ulcers ntawm lub plab thiab duodenum 12);
• thaum lub sij hawm thawj peb lub hlis uas cev xeeb tub thiab lactation;
• nyob rau hauv kev mob loj raum los yog hepatic puas;
• thaum kev tsis haum tshuaj rau salicylates;
• nyob rau hauv cov me nyuam yau tshaj 18 xyoo;
• nyob rau hauv lub xub ntiag ntawm bronchial hawb pob;
• nyob rau hauv cov kev kho mob ntawm methotrexate.

Cov contraindications yog tsis, txawm hais tias tej lub sij hawm: lactation, cev xeeb tub, yaig thiab ulcers ntawm tus mob huam, kiag. Thiab kuj muaj yog ib tug pab pawg neeg ntawm lub xeev, lub xub ntiag ntawm uas yuav tsum tau tas li xyuas los ntawm ib tug kws kho mob. Qhov no simultaneous siv antiplatelet kho nrog anticoagulants, thiab kev kho mob ntawm cov neeg mob tom qab coronary artery bypass phais. Yog hais tias lub raum muaj nuj nqi ua ntawv thov mus rau yeeb tshuaj "Aspekard" cov lus qhia rau kev siv yuav tsum tau ntau npaum yuav txo tau los yog ua kom tiav cov gradual abolition ntawm cov tshuaj.

Joint los "Aspekard"

Acetylsalicylic acid muaj ib tug xov tooj ntawm cov teebmeem uas txhim khu los yog mluas qhov kev txiav txim ntawm ob peb tshuaj. Nyob rau hauv kev:

• ASA tej cov nyhuv ntawm tej anticoagulants thiab antiplatelet agents;
• ASA tej antipyretic thiab analgesic nyhuv ntawm narcotics yuav muab, amplifies antirheumatic nyhuv "Meloxicam";
• thaum ua ke nrog cytotoxic tshuaj tej lawv gastrotoxicity;
• thaum noj nrog haus dej haus cawv kev pheej hmoo ntawm lub rwj mob los yog los ntshav nce;
• glucocorticoids nce gastrotoxicity "Aspekard";
• ACK attenuates diuretic nyhuv thaum ua ke nrog diuretics "Furosemide", "torasemide", "spironolactone".
• "Aspekard" tsis muaj zog txog cov nyhuv ntawm uricosuric agents, "Probenecid", "Etamid", "sulfinpirazon";
• nonabsorbable antacids txo qhov haum ntawm "Aspekard".

Qhov ntau yam ntawm ib tug overdose thiab nws cov tsos mob

Kuj tshuaj "Aspekard" kev qhia ntawv, cov tswv yim thiab kev siv cov statistics paub meej tias ib tug high txaus theem ntawm kev ruaj ntseg nyob rau hauv cov txais tos raws li indications thiab contraindications kos. Qhov no txhais tau tias cov tshuaj txhaj koob tshuaj ntawm 100 mg ntawm cov tshuaj yog muaj kev ruaj ntseg txaus, txawm hais tias tus tswj ntawm lub xeev kev kho mob yog tsim nyog. Ntxiv mus, nyob rau hauv view ntawm lub pab peeb zeej tuaj ntawm cov neeg mob nrog suicidal tendencies, raws li zoo raws li kev pheej hmoo tias rau ntsiav tshuaj ntawm ASA yuav coj tus me nyuam, nthuav dav yuav tsum tau tshwm sim overdose thiab nws cov tsos mob.

Me me lom salicylates, provoked los ntawm daim ntawv thov ntawm cov kev npaj "Aspekard" tsis muaj ib tug kws kho mob pom zoo cov tsos mob yog cov nram qab no hais tias: kiv kiv taub hau, mob nyob rau hauv lub fossa podlozhechkovoy, txoj hlab cheeb tsam, tej zaum mob, tshwj xeeb tshaj yog nyob rau hauv cov neeg mob uas raum kab mob. Nyob rau hauv cov ntaub ntawv ntawm overdose raws li muaj yog lawv tshee hnyo rau, ntuav, tej zaum nrog ntshav streaks. Tus thawj yog ntawm lub dag induction ntawm emesis: tshaj txias haus, txais hluav ncaig txoj kev thiab ehnterosorbentov tus me nyuam tus neeg mob nyob rau hauv lub tsev kho mob.

Ceeb tshaj, cov tshuaj lom koob tshuaj "Aspekard" phau ntawv qhia tsis qhia kom meej. Lawv yog cov sib txawv rau txawv nyhav thiab muaj hnub nyoog ntawm tus neeg mob. Piv txwv li, nyob rau hauv ib tug neeg laus tib neeg overdose tshwm sim me me ASA tshwm sim nyob rau ib nkag txog 5-7 grams acid. Cov me nyuam muaj txaus rau ib tug overdose ntawm 1.5 g ib koob tshuaj. Ib tug loj overdose tshwm sim thaum koj thov 7-9 grams ntawm cov neeg laus thiab cov me nyuam 2-2.5 gram ASA.

Qhov no degree ntawm yeeb tshuaj overdose manifested los ntawm cov saum toj no mob uas muaj kev txawj ntse zog. Poob lawm daim ntawv pib tinnitus xav yuav tsis meej pem, incoherent hais lus. Ntuav feem ntau tshwm sim, tus neeg mob sai sai poob kua los ntawm ntuav, ua tsis taus pa quickens, muaj mob urinary tuav, nce lub cev kub. Pab tus neeg mob nyob rau hauv xws li ib tug teeb meem no nws yog tsis yooj yim sua rau nws tus kheej - tus me nyuam yog yuav tsum tau nyob rau hauv lub NICU rau Txoj kev lis ntshav txoj kev kho bicarbonate, sodium lactate.

Nta ntawm tshuaj txiav txim "Aspekard"

Txuas mus rau lub tshuaj "Aspekard" kev khiav hauj lwm qhia ntawv muaj ib qho hais txog ntawm lub txais tos ntawm ib ntsiav tshuaj ib hnub twg (100 mg / hnub). Qhov no tshuaj ASA yog txaus rau inhibit platelet cyclooxygenase. Cov no inhibition ntawm synthesis ntawm thromboxane A2, uas tag cheeb qhov uas cov muaj peev xwm ntawm lub hlwb los platelet aggregation. Eliminates qhov no tau thrombosis, uas yog qhov ua rau ntawm myocardial los yog cerebral infarct.

Yuav kom muab antithrombotic nyhuv ntawm acetylsalicylic acid yuav tsum tau absorbed rau hauv cov ntshav. Txawm li cas los, ib co ntawm nws ua nyob rau hauv lub plab thiab kuj inhibiting cyclooxygenase-1 thiab nws cov isoforms nyob rau hauv lub mucosa ntawm qhov hloov. Cov tshwm sim ntawm no mechanism yog lub sab nyhuv - txo muaj peev xwm muco-tiv thaiv carbonate. Qhov no yuav tsub kev txaus ntshai ntawm erosions thiab ulcers ntawm lub plab, nkoos hnyuv-los ntshav. Enteric formulations yog tseem tau ntxias los ntshav, tab sis lub zaus ntawm no sab nyhuv, lawv muaj tsis tshua muaj neeg me me.

Cev xeeb tub thiab lactation

Kws muaj txuj tswv yim, raws li nyob rau hauv lub statistical kev ntsuam xyuas thiab ib tug series ntawm thwmsim, uas koj yuav muaj ib tug to taub kom meej hauv daim ntawv thov ntawm "Aspekard" cov tshuaj thaum lub sij hawm cev xeeb tub. Nyob rau hauv kev, 1 peb lub hlis nws siv yog txwv tsis pub. Thaum 2 thiab 3 peb lub hlis daim ntawv thov tso cai, tab sis tom qab kev luj xyuas ntawm nws kho siv thiab muab piv rau cov txais tos txaus ntshai. Nyob rau hauv lub loj heev feem ntau ntawm cov kev soj ntsuam lub sijhawm teem caij ASA tsis tas, txawm hais tias lwm narcotics yuav muab yog tseem tau ua rau kom cov kev pheej hmoo ntawm nchuav menyuam.

Thaum lub sij hawm lactation, siv cov tshuaj "Aspekard" analogues nws, Generics, raws li zoo raws li tag nrho cov tshuaj uas acetylsalicylic acid nyob rau hauv muaj pes tsawg leeg yog txwv tsis pub. Yog vim li cas rau qhov no yog ntaus cov tshuaj nyob rau hauv niam cov kua mis. nws penetrates txawm nrog nws nyob rau hauv tus me nyuam lub cev. Thiab nws txaus ntshai yog yuav muaj tsim Reye syndrome - ib tug tsis tshua muaj mob loj hepatic encephalopathy, uas ua rau lub hlwb o thiab kev tuag ntawm ib tug me nyuam. Rau yam uas zoo li, txwv tsis pub siv ntawm cov tshuaj ua ntej lub hnub nyoog ntawm 16-18 xyoo.

Specifications Xyuas cov tub txawg thiab cov neeg mob

Characterizing cov tshuaj "Aspekard" neeg mob tawm tswv yim nyob rau hauv ntau biased. Lawv zoo soj ntsuam tus nqi ntawm cov tshuaj, vim nws yog yuav luag tus nqi qis tshaj ntawm cov phooj ywg. Txawm li cas los, cov lus hais txog lub tswv yim daim ntawv thov ntawm cov uas tsis tshua indicative ntawm lub cev tsis mus ntsuam xyuas cov neeg kawm ntawv ntawm cov neeg mob txo txoj kev pheej hmoo ntawm vascular thrombosis. Nyob rau hauv cov nqe lus ntawm cov kev phiv qhia los ntawm cov neeg mob, cov tshuaj yog yus li sufficiently kev nyab xeeb.

Tswvyim ntawm cov kws txawj muaj tseeb: firstly, cov tshuaj yog zoo nyob rau hauv txo txoj kev pheej hmoo ntawm thrombosis, thiab tib ob, cov neeg mob raws li antiplatelet txoj kev kho yog dua vim hais tias ntawm qhov uas tsis muaj "Aspekard" nqi ntawm cov tshuaj. Analogs ntawm cov chav kawm ntawv ntawm antiplatelet agents yog ho muaj dua. Domestic enteric npaj "Atsekardol" kim kim los ntawm 50%, thaum lub sij hawm tus nqi ntawm txawv teb chaws ntau dua los ntawm 7-10 lub sij hawm. Tab sis raws li nyob rau hauv tsawg phiv enteric agents, raws li zoo raws li lub economic tshawb pom, nws yog ntshaw kom muab feem rau "Atsekardolu". Tus nqi ntawm cov kev kho mob txhua hli yuav tsum yog hais txog 20 rubles.

Lub hom phiaj tsis muaj kardiopreparata "Aspekard"

Txuas mus rau lub tshuaj "Aspekard 100" phau ntawv qhia hais tias cov tshuaj yog muaj nyob rau hauv cov ntsiav tshuaj. Lawv yaj nyob rau hauv lub plab thiab tsim ib tug siab concentration. Muab lub zos gastrotoksichesky nyhuv, cov tshuaj loses Safety Lwm yam tshuaj, namely enteric. pais plab los ntshav yuav raug thaum ua ntawv thov cov tom kawg yog npaum li cas tsawg.

Piv txwv ntawm kev ruaj ntseg cov tshuaj raws li nram no: "Atsekardol", "Polokard", "Cardiomagnyl", "Tshuaj aspirin cardio." Ntxiv mus, hais tias txhais tau hais tias kuj comprise magnesium hydroxide, tau los tiv thaiv lub mucosa ntawm kev raug mob los ntawm acetylsalicylic acid. Cuaj kaum, cov tshuaj "Aspekard" tej zaum yuav siv rau kev tiv thaiv ntawm thrombus tsim, albeit nrog txwv. Txawm li cas los, cov neeg mob muaj mucosal yaig, rwj 12 duodenum los yog plab, xws li tus mob, nws yog pom zoo kom noj enteric kardioformy acetylsalicylic acid.

Vneotraslevoe daim ntawv thov kardiopreparata "Aspekard"

Feem ntau ntawm cov muaj cov lus qhia rau kev siv ntawm lub muaj antiinflammatory thiab antipyretic zog tshuaj "Aspekard 100". Nyob rau hauv qhov tseeb, tag nrho cov kev kho muaj tshuaj los yog 5 lub sij hawm ib koob tshuaj - 500 mg. Cov tshuaj ntawm 100 mg yog heev dua lwm yam mob, thiab nws cov nyhuv yog tsis txaus rau zoo txo kub nyob rau hauv kis kab mob.

Kardioforma npaj manufactured nyob rau hauv ib koob tshuaj ntawm 100 mg, yog haum rau mob thiab kub ib ce nyem tsuas nrog ib koob tshuaj 5 ntsiav tshuaj. Yog li predominance selectivity rau cyclooxygenase 1 txiav txim hauv lub xub ntiag ntawm ib tug plurality ntawm sab tshua. Yog li ntawd, raws li ib tug febrifuge "Aspekard" tshuaj, ntawm chav kawm, yog tsis tsim. Txawm li cas los, thaum lub caij muaj ib tug xov tooj ntawm ib tug xov tooj ntawm kev ruaj ntseg cov tshuaj seeb ntau dua selectivity rau cyclooxygenase 2. Lawv kuj tau tsawg dua phiv nrog qhov tau ua txhaum ntawm lub loj hlob ntawm txoj hnyuv epithelium.

Kev Nyab Xeeb hauv chav kawm ntawv counterparts "Aspekard" tshuaj

Ib tug zoo xws li cov qauv muaj cai nyob rau hauv cov kev kho mob ntawm rheumatic kab mob. Thiab daim ntawv mus rau yeeb tshuaj "Aspekard" qhia rau kev siv cov kev qhia txog lawv cov kev kho mob. Txawm li cas los, cov pom zoo koob tshuaj yog ntawm qhov kev txiav txim ntawm 5-8 grams tauj ib hnub.

Cov nyiaj no ntawm acetylsalicylic acid qhia tau hais tias gastrotoxicity incomparably muaj zog nyhuv tshaj thaum "meloxicam" Pharmaceuticals, "celecoxib", "Roferoksib" thiab lwm tus neeg. Thiab raws li antipyretic zoo tshaj plaws hauv chav kawm ntawv analogue yog "Ibuprofen".