ALT nce. Yuav ua li cas?

alanine aminotransferase (ALT) enzyme muaj nyob rau hauv lub siab siv raws li ib tug qhia rau ntes mob ntawm nws functions. Li cas rau cov tseeb, yog ALT theem nce?

Ntawm cov ntau enzymes uas yog ntsuas ntawm hepatocellular mob, feem ntau pab tau thiab tsim nyog yog alanine aminotransferase (ALT) thiab aspartate aminotransferase (AST). Los ntawm lawv ceev hloov cov tshuaj tiv thaiv nyob rau hauv ib tug gamma-gamma band ketoglutarate alanine thiab aspartate pawg. Raws li ib tug tshwm sim ntawm txoj kev no ua pyruvic thiab oxaloacetic acid.

Thiab ALT thiab AST - cellular enzymes raum, siab, plawv. Txawm li cas los, alanine aminotransferase, mas nyob rau hauv daim siab thiab yog lub feem ntau yooj yim ntawm nws cov qhov taw qhia, thiab aspartate aminotransferase -. Raws li ib feem ntawm ntau (lwm yam tshaj li cov neeg uas muaj npe saum toj no) hauv nruab nrog cev thiab cov nqaij mos, nrog rau skeletal nqaij, lub hlwb, thiab lwm yam no yog vim li cas tus yuam sij enzyme AST yog tsis tshua muaj heev raws li ib tug qhia ntawm lub siab muaj nuj nqi, thiab nws yuav siv sij hawm yog ib feem nyob rau hauv amino acid metabolism.

Yog hais tias muaj yog kev puas tsuaj ntawm mob hlwb, plawv, raum, alanine aminotransferase (ALT) nyob rau hauv cov ntshav uas yuav ntog. Nce ntawm cov cellular enzyme nyob rau hauv cov ntshav muaj pes tsawg leeg qhia latent kab mob. Thaum tshawb fawb qhia tias siab ALT ntau ntau, tej zaum yuav tsim heev loj kab mob nyob rau hauv cov ntshav, xws li:

- mob npuas paug,

- kab mob kab mob siab,

- myocarditis,

- lub siab ua cancer,

- lub plawv tsis ua hauj lwm,

- ib lub plawv nres.

Thiab qhov kev nce rau aspartate aminotransferase nyob rau hauv cov ntshav yuav ua rau

- lub plawv nres,

- lub siab ua cancer,

- npag dystrophy ,

- pancreatitis,

- paroxysmal myoglobinuria,

- kab mob siab,

- dermatomyositis,

- lub plawv tsis ua hauj lwm.

Yog hais tias, txawm li cas los, lub zuag qhia tag nrho tus nqi ntawm AST thiab ALT ntau zog, tej zaum yuav muaj:

- uas nws kim heev hepatic necrosis,

- toksinogennye siab raug mob,

- mob loj heev kis kab mob siab,

- long-leeg tshav cev qhuav dej.

Yuav luag tag nrho cov kab mob ntawm tib neeg cov ntshav kev tshawb fawb qhia tau tias cov nqi thiab AST, thiab ALT nce, uas yog, cov theem ntawm tag nrho ob qho enzymes nyob rau hauv cov neeg mob yog yuav luag tib yam thiab qhia tau hais tias lub xub ntiag ntawm pathology. Tab sis muaj yog tsis tau lwm sib txawv. Yog hais tias ALT theem nce rau ib tug ntau dua twg aspartate aminotransferase, uas qhia rau hauv lub tsim kom loj hlob lub sij hawm ntawm tus kab mob siab B mob. Yog hais tias cov ntshav ACAT ntau, nws ntau zaus nrog lub plawv muaj teeb meem.

Nyob rau hauv ib tug neeg noj qab nyob rau hauv lub txheem ntawm cov cellular enzymes yuav tsum nyob rau theem:

- nyob rau hauv cov txiv neej mus txog 41 units ib liter (U / L);

- nyob rau hauv cov poj niam mus txog 31 units ib liter (U / L).

Kom paub tias cov theem ntawm cov enzymes, protein metabolism, coj cov ntshav Science News for KIDS. Cai rau ALT therein yuav 28-190 nmol / (c l) los yog 0.1, 68 mmol / (mL hr) thiab rau ACAT - 28-25 nmol / (c l) los yog 0,1-, 45 pmol / (mL hr). Qhov no txoj cai yog nyob rau hauv ob leeg yog muab rau cov qauv ntawm cov Reitman-Frankel (colorimetric txoj kev ntawm kev tshawb fawb).

Feem ntau, kev kuaj ntshav alanine aminotransferase ua kom paub txog lub xeev ntawm lub siab, thiab aspartate aminotransferase - mus saib hauv lub xeev ntawm lub myocardium (lub plawv mob). Yog hais tias tus tsom xam qhia tau hais tias lawv cov ntshav, nws txhais tau tias kev ntawm kev puas tsuaj thiab ntawm tes tuag tshwm sim nyob rau hauv cov kabmob. Yog li ntawd, yog tias AST tshaj cov theem nyob rau hauv cov ntshav nyob rau hauv lub 2-20 lub sij hawm, ces nws yog tau txoj kev loj hlob ntawm myocardial infarction. Yog hais tias ALT theem nce, muaj yog ib tug pathological txheej txheem nyob rau hauv lub siab.

Nyob rau hauv luv taw qhia ntawm cov ntshav alanine aminotransferase thiab aspartate aminotransferase cov kws txawj paub hais tias lub cev tsis muaj lub pyridoxine (vitamin B6). Feem ntau qhov no tshwm sim thaum lub sij hawm cev xeeb tub, nrog heev hemodialysis thiab lub raum tsis ua hauj lwm.

Tu siab, los ntawm ib tug ntshav ntshiab ntawm ib tug neeg noj qab nyob yog cov enzymes yog tsis paub hais tias, yog li cov unintelligible thiab lawv mechanism ntawm clearance (tus nqi ntawm kev ceev ntawm cov ntshav kho mob, lwm cov bioliquid thiab ntaub so ntswg ntawm tej tshuaj vim hais tias ntawm lawv cov redistribution, biotransformation, tshem tawm ntawm lub cev).