Alkaline phosphatase - ib qho enzyme marker

Nyob rau hauv kev xyaum, clinicians yog feem ntau ntsib nrog ib tug cia li nce nyob rau hauv alkaline phosphatase kev ua si. Los ntawm kev siv ntawm multi-xeem cov khoom siv rau biochemical kev tshawb fawb nws muaj lub sij hawm los tswj cov kev ua ntawm cov enzyme. Raws li mus rau theem ntawm kev ua si ntawm hais tias enzyme yuav ntes cov kab mob ntawm lub hepatobiliary system thiab tus pob txha cov ntaub so ntswg.

Alkaline phosphatase - ib qho enzyme uas belongs rau lub chav kawm ntawv ntawm hydrolases, cleaving ib phosphate pab pawg neeg los ntawm txawv biopolymers (cov nqaijrog, nucleic acids, alkaloids). Qhov siab tshaj plaws enzyme ua si muaj cai nyob rau hauv ib tug alkaline ib puag ncig. Lub enzyme yog nyob rau hauv lub hlwb txuam nrog cov ntshav daim nyias nyias ntawm lub xeev, yog li ntawd nws yog hais txog cov daim nyias nyias-ua txhua yam enzymes. Alkaline phosphatase (ALP) yog tsim los ntawm cov sib txawv isozymes uas muab tso rau hauv lub epithelium zhelchnovyvodnyh ducts plasmatic daim nyias nyias ntawm hepatocytes thiab neurons, cov pob txha, hnyuv, tsev me nyuam, lub raum.

Txiav txim seb kev ua ntawm isoenzymes los ntawm kev siv electrophoresis. Txawm li cas los, ALP isozymes tsis muaj ib tug meej hloov khoom nruab nrog tseem, thiab electrophoretic txoj kev yog heev yooj yim. Yog li ntawd, mus piv rau cov kev tshawb fawb uas siv cov ib tug txheej txheem uas yog raws li nyob rau hauv qhov sib txawv isoenzymes rhiab heev rau thaum tshav kub kub. Plab hnyuv alkaline phosphatase koom thermostable feem thiab isozymes ntawm daim siab thiab pob txha - ib tug thermolabile. Feem ntau cov sensitive rau thaum tshav kub kub yog pob txha phosphatase.

Ntshiab alkaline phosphatase yog ib tug sib tov ntawm cov pob txha thiab lub siab isoenzymes. Tso enzyme los ntawm cov ntshav mus rau txawv nqaij nyob rau hauv lub physiological lub xeev thiab cov hnub nyoog ntawm tus kab mob (cev xeeb tub, parturition, lactation siv). Lub siab ua si ntawm alkaline phosphatase nyob rau hauv cov ntshav ntawm cov hluas yog vim qhov khaus lag luam ntawm osteoblasts nyob rau hauv cov pob txha ntaub so ntswg, uas yog tshwm sim los ntawm cov txheej txheem ntawm active kev loj hlob ntawm tus kab mob. Thaum lub sij hawm no lub sij hawm, lub enzyme ua si nyob rau hauv cov ntshav qab vim tus pob txha isoenzyme. Nyob rau hauv lub thib ob ib nrab ntawm cev xeeb tub thiab me nyuam txawj nce thiab cov kev puas tsuaj ntawm lub tsho me nyuam ua ib qho kev nce rau hauv lub concentration ntawm placental isoenzyme.

Ua lub concentration ntawm alkaline phosphatase nyob rau hauv cov ntshav feem ntau yog sau npe nyob rau hauv lub pathology ntawm lub siab thiab pob txha. Parenchymal lub siab puas ua rau ib tug me ntsis nce nyob rau hauv enzyme ua si nyob rau hauv cov ntshav ntshiab, raws li alkaline phosphatase txuam nrog cell week. Nyob rau hauv soj ntsuam hepatology siab isoenzyme yog indicative rau qhov mob ntawm cholestasis. Qhov no yog vim muaj zog synthesis ntawm cov kua tsib ciav hlwb AP thiab enzyme rho tawm ua txhaum nyob rau hauv bile. Hyperenzymemia yog tshwj xeeb yog high school thaum lub sij hawm txoj kev loj hlob ntawm pathologic txheej txheem thiab cov kua tsib stasis nyob rau hauv daim siab cov kua tsib ducts. Ces tus enzymatic kev ua ntawm alkaline phosphatase nyob rau hauv cov ntshav ntshiab yog nce tenfold. Yog hais tias qhov kev puas tsuaj intrahepatic biliary enzyme ua si nyob rau hauv cov ntshav qab tsuas 2-3 lub sij hawm. alkaline phosphatase cai rau cov neeg laus mus txog 31 xyoo ua 39,0-92,0 IU / L tom qab 31 xyoo - 39,0-117,0 IU / L. Alkaline phosphatase tus nqi nyob rau hauv cov me nyuam nyob rau hauv 10 xyoo - 106,0-213,0 IU / L mus rau 3 lub xyoos - 71,0-213,0 IU / l, thiab rau cov me nyuam mos - 35,0-106,0 IU / L.

Nyob rau hauv lub pathology ntawm cov pob txha, thaum muaj yog nce ua si ntawm osteoclasts, thaum lub sij hawm txoj kev loj hlob ntawm rickets, osteodistorofii, hyperparathyroidism nyob rau hauv cov ntshav tsub kom cov kev ua ntawm cov pob txha alkaline phosphatase. Nyob rau hauv cov ntaub ntawv no, tag nrho cov alkaline phosphatase kev ua si nyob rau hauv cov ntshav nce los ntawm 3-10 lub sij hawm. Rau thaum ntxov mob ntawm rickets thiab osteodystrophy yog ib qho kev nce rau hauv phosphatase kev ua si nyob rau hauv lub synovial cov kua. Qhov nce nyob rau hauv alkaline phosphatase kev ua si nyob rau hauv lub hlwb txha nqaj qaum kua yog ib tug kos npe rau ntawm lub yeej ntawm neuronal week, qhov twg nws yog ib ncig.