Yuav ua li cas "Lyrics" ntsiav tshuaj? Cov kev siv ntawm tus nqi

Tshuaj "lyrics" (ntsiav tshuaj), tus nqi ntawm uas yog los ntawm 700 mus 4000 rubles., - sufficiently zoo-paub tshuaj. Active tshuaj - pregabalin - analog ntawm gamma-aminobutyric (GABA) acid (GABA). Tom qab ntawd nyob rau hauv qhov tsab xov xwm yuav muab annotation tshuaj. Cia peb nrhiav tau tawm yog dab tsi tshuaj "Lyrics" siv cov neeg mob.

mechanism ntawm qhov kev txiav txim

Pregabalin exhibits nws miv nyuas siv zug nyob rau hauv cov kev kho mob ntawm ntshav qab zib neuropathy thiab postherpetic neuralgia, rau cov uas tshuaj "lyrics" tshuaj nqi mus txog 13 lub lis piam nrog ib tug txhua txhua hnub kom tsawg tus nqi 2 lub sij hawm thiab mus txog rau 8 lub lis piam, 3 lub sij hawm ib hnub twg. Tawm tsam tom qab ntawm txoj kev loj hlob ntawm cov txhais tau tias qhia tib yam tshwm sim. Txuam nrog fibromyalgia yog kom meej meej pom yuav txo tau nyob rau hauv mob cov tsos mob taw tes thaum noj cov tshuaj txhaj koob tshuaj ntawm 300-600 mg ib hnub twg. Txhua hnub ntau npaum ntawm 450 mg thiab 600 mg yuav muab piv rau efficiency, tab sis lub caij nyoog kawg no yog tsis tshua tau zam lub txim rau. Cov tshuaj thiaj li heev ntawm epileptic qaug dab peg, uas ntsiav tshuaj "lyrics" pom zoo kom ib chav kawm ntawm 12 lub lis piam, 2 los yog 3 zaug ib hnub twg. Thaum lub sij hawm txais tos tshwm sim tib lub qauv ntawm cov mob tshwm sim thiab cov hauj lwm zoo ntawm cov tshuaj nyob rau hauv qhov koob. qaug dab peg zaus pib kom txo tau twb nyob rau hauv thawj lub lim piam ntawm kev kho mob. Symptomatology ntawm generalized kev ntxhov siab vim teeb meem qhia tau hais tias ib tug ib txwm kom txo tau nyob rau hauv thawj xya hnub ntawm kev kho mob. Tom qab yim lub lis piam 52% ntawm cov tshuaj cov neeg mob uas tau txais pregabalin thiab 38% ntawm cov neeg mob uas tau txais cov placebo, pom ib tug 50 feem pua yuav txo tau nyob rau hauv cov tsos mob ntawm lub Hamilton scale (Ham-A).

tshuaj

Lub medicament "lyrics" (ntsiav tshuaj) - Tus neeg siv qhia no - nyob rau hauv lub pom zoo txhua hnub koob tshuaj nrog sab pharmacokinetic yus linearity, tsis tshua muaj (<20%) interindividual variability. Ua daim ntawv thov ntawm cov tshuaj ntawm cov tshuaj yuav tsum tau muab kwv yees rau lub hauv paus ntawm ib chav tsev ntawm ntau npaum cov ntaub ntawv. Yog li ntawd tsis tu ncua saib xyuas lub concentration ntawm active ingredient yog tsis tsim nyog. Pharmacokinetic ciaj ciam ntawm cov tshuaj "Lyrics" nyob rau hauv kev noj qab nyob tuaj pab dawb, cov neeg mob uas tau qaug dab peg uas tau txais antiepileptic txoj kev kho, raws li tau zoo raws li uas tau txais cov tshuaj rau suppressing mob syndromes yog zoo sib xws.

Haum thiab tshem tawm

Tom qab noj rau ib qho kev npliag plab pregabalin yog absorbed sai sai heev. Ib teev tom qab ntawd, cov ntshav Cmax tiav raws li thaum ua ntawv thov rau thawj lub sij hawm, thiab nrog rov qab. Nyob rau hauv keeb kwm yav dhau ntawm pregabalin qhov ncauj bioavailability yog ≥90% thiab yog ywj siab ntawm koob tshuaj. Equilibrium yog tiav thaum noj dua nyob rau hauv ib lub sij hawm ntawm 24-48 teev. Yog hais tias cov tshuaj yog thov tom qab ib tug noj mov, Cmax tej zaum yuav txo los ntawm 25-30% thiab ua rau kom nws cov kev kawm lub sij hawm rau 2.5 sij hawm. Txawm li cas los, tsis muaj clinically ho ua rau qhov haum ntawm cov tshuaj tsis muaj zaub mov noj. Yeej cov tshuaj tas los ntawm ob lub raum unchanged. T1 / 2 nruab nrab ntawm 6.3 lub sij hawm.

Tshuaj nyob rau hauv tshwj xeeb mob

Yog hais tias koj nyom raum muaj nuj nqi, nws yog tsim nyog los noj mus rau hauv tus account lub peculiarity ntawm pregabalin clearance, nws yog ncaj qha proportional rau creatinine clearance. Yeej cov tshuaj tas los ntawm ob lub raum, yog li ntawd nws yog tsim nyog nyob rau hauv cov ntaub ntawv ntawm ua txhaum ntawm lawv lub zog los txo cov tshuaj tsawg. Sib nrug los ntawm ob lub raum, lub medicament yuav zoo muab tshem tawm los ntawm cov ntshav los ntawm hemodialysis (4-teev hemodialysis kev sib kho muab 50% txo nyob rau hauv cov tshuaj nyob rau hauv concentration ntshav) thiab ces ntau ntshaw lub sij hawm cov tshuaj txhaj koob tshuaj. Ib tug tshwj xeeb kev tshawb ntawm cov tshuaj ntawm cov kab mob "Lyrics" nyob rau hauv cov neeg mob uas impaired siab muaj nuj nqi tsis tau ua.

Pregabalin metabolized yuav luag tsis raug, yog tso tawm ua ke nrog cov zis nyob rau hauv unchanged daim ntawv no, txawm li cas los tsis hnov lub siab muaj nuj nqi tsis ho muaj kev cuam tshuam lub concentration ntawm cov tshuaj nyob rau hauv ntshav. Thaum cov tshuaj yog muab rau cov neeg mob tshaj 65 xyoo ntawm lub hnub nyoog, koj yuav tsum dais nyob rau hauv lub siab hais tias nrog lub hnub nyoog Pregabalin clearance nyhav kom txo tau. Yog hais tias ib tug neeg laus neeg ntawm poob raum muaj nuj nqi, nws yog tsim nyog yuav txo tau nyob rau hauv tshuaj txhaj koob tshuaj.

ntau npaum

Lub sij hawm npaum li cas ntawm cov kev npaj hais tseg nyob rau hauv lub 150-600 mg ib hnub twg. Nkag yog nqa tawm ob zaug los peb zaug, tsis hais cov mov noj. Lub medicament "lyrics" (ntsiav tshuaj) phau ntawv qhia kom noj nrog neuropathic mob ntawm 150 mg ib hnub twg. Yog hais tias lub tiav nyhuv thiab tolerability zoo ib lub lim tiam hnub koob tshuaj yuav tau nce mus rau 300 mg (teev "lyrics 300" ntsiav tshuaj). Yog hais tias tsim nyog, lub siab tshaj plaws tshuaj ntawm 600 mg ib hnub twg tej zaum yuav muab ib lub lim tiam tom qab. Ib yam li ntawd xam koob thaum cov kev kho mob ntawm qaug dab peg. Raws li twb hais saum toj no, nws pom zoo tshuaj rau cov kev kho mob ntawm fibromyalgia, uas ntsiav tshuaj "lyrics" yog muab nyob rau hauv ib koob tshuaj 75 mg ib hnub twg nyob rau hauv ob koob tshuaj. Nyob rau ua cov tshuaj mus rau 300 mg cuam tshuam rau tiav nyhuv thiab tolerability. Yog hais tias muaj yog tsis muaj zoo ntxim, nce lub koob tshuaj rau 450 mg, thiab yog hais tias yuav tsum tau - ib lub lim tiam rau 600 mg. Kho generalized kev ntxhov siab vim teeb meem pib nrog ib koob tshuaj ntawm 150 mg. Tsis tas li ntawd ib lub lim tiam, tsom kwm tus tiav cov nyhuv thiab tolerability, txhua hnub koob tshuaj ntau zog rau 450 mg, thiab tom qab 7 hnub - txog li 600 mg (yog tias tsim nyog).

tshem tawm ntawm cov tshuaj

Yog hais tias tsim nyog, kev kho mob discontinuation yog pom zoo kom ua nws yam tsawg kawg yog ib lub lim tiam ib tug gradual yuav txo tau nyob rau hauv koob tshuaj. Cov neeg mob uas tau lus zoo raum muaj nuj nqi, nqa tawm ib tug neeg xaiv ntawm koob tshuaj. Nyob rau hauv cov kev tshwm sim ntawm kev phiv los nyob rau hauv cov neeg mob uas tau txais txhais tau tias "Lyrics" ntsiav tshuaj-kom muaj sib npaug xaiv cov kws muaj txuj. Ntawm cov feem ntau txhais tau tias zoo li cov nyhuv tej zaum yuav hais cov tshuaj "Mydocalm" "Apizartron" "Sedavit" "Ambene".

zaj lus tim khawv

Tshuaj yog pom zoo rau cov tshem tawm ntawm neuropathic mob, raws li adjunctive txoj kev kho rau ib nrab qaug dab peg ntawm qaug dab peg, uas yog nrog los yog tsis nrog theem nrab generalization. Txhais tau tias qhia rau kev ntxhov siab vim teeb meem generalized xwm, raws li zoo raws li fibromyalgia.

Contraindications

Yog tsis muaj cov ntaub ntawv nyob rau kev siv ntawm cov tshuaj nyob rau hauv cov me nyuam thiab cov tub ntxhais hluas mus rau 17 xyoo inclusive. Nyob rau hauv kev twb kev txuas nrog cov tshuaj no yog muab tsuas rau cov neeg laus. Contraindications muaj xws li raws roj ntsha cov kab mob raws li galactose intolerance, lactase tsis muaj peev xwm, raws li zoo raws li malabsorption ntawm zib / galactose. Lub cuab tam yog tsis qhia rau meem kev txhawj xeeb. Kom muaj ib tug ua tib zoo siv cov tshuaj nyob rau hauv cov neeg mob uas raum thiab lub plawv tsis ua hauj lwm.

phiv

Raws li qhov kev paub ntawm cov kev soj ntsuam daim ntawv thov ntawm cov medicament, nyob rau hauv cim nkees nkees thiab kiv taub hau li undesirable txim. Cov phenomena yuav tshwm sim nyob rau hauv mob loj tsawv lossis mob me me degree. Cov lwm sab los ua nyob rau hauv discontinuation ntawm yeeb tshuaj kho mob, nws yuav tsum tau muab sau tseg asthenia, tsis meej pem, qhov muag plooj tsis pom kev, incoordination, ataxia, peripheral edema. Tsis tas li ntawd ntawm cov tsis zoo los muab sau mob taub hau, tsis nco qab, qaug dab peg, o ntawm tus nplaig, raws plab, xeev siab, keratitis. Feem ntau yeej tsis muaj cov pob khaus tawv nqaij thiab angioneurotic cov tshuaj tiv thaiv. Muaj urinary tuav, pulmonary edema thiab gynecomastia. Cov lwm sab los yog hu ua qaug zog.