Pob necrosis Factor: npaj

Pob necrosis tau (TNF) - ib pab pawg neeg ntawm cytokines kev protein - hormone zoo li tshuaj ua los ntawm lub cev. Nws ua rau ib tug ntau ntawm kev txaus siab nyob rau hauv cov tshuaj vim nws cov khoom - muaj peev xwm ntxias ntawm tes tuag (necrosis) intratumoral cov ntaub so ntswg. Qhov no yog ib tug tiag tiag txhob nyob rau hauv cov tshuaj, uas koj mus thov cov khoom uas muaj TNF rau cov kev kho mob ntawm cancer.

Keeb kwm ntawm foundations

By pib ntawm lub XX xyoo pua nyob rau hauv kev kho mob xyaum nws tau raug kuaj qauv: nyob rau hauv ib co neeg mob muaj yog ib tug txo thiab / los yog disappearance ntawm mob tsim tom qab cov kev hloov ntawm tej kab mob. Ces American kws ntawv William Coley pib txhob txwm tshaj tawm muab muaj mob cancer tshuaj uas muaj kab mob hauv tsev (cov kab mob thiab lawv cov co toxins). Cov kev tsis pom yuav zoo, raws li muaj ib tug muaj zog tshuaj lom ntxim rau cov neeg mob. Tab sis nws yog pib ntawm ib tug xov tooj ntawm cov kev tshawb fawb ua rau lub foundations ntawm ib tug protein, hu ua lub qog necrosis tau. Pom substance ua ceev ceev tuag ntawm kev mob hlwb implanted nyob rau hauv daim tawv nqaij ntawm kev sim nas. Ib me ntsis tom qab, nws twb cais ntshiab TNF, uas tso cai rau siv rau kev tshawb nrhiav.

Qhov no discovery pab mus rau ib tug txhob nyob rau hauv kev kho mob cancer. Yav tas los, siv cov proteins cytokines tau ntse kho cancer yog cov cia li ib ob peb ntawm kev kawm ntawv - melanoma daim tawv nqaij cancer, mob raum mob cancer. Txawm li cas los, tseem ceeb kev kawm nyob rau hauv daim teb no tau tso cai rau txoj kev tshawb no ntawm cov khoom muaj los ntawm lub qog necrosis tau. Npaj raws li nws muaj nyob rau hauv lub kws khomob txoj kev.

mechanism ntawm qhov kev txiav txim

mob necrosis tau ua nyob rau hauv ib lub cell - lub hom phiaj. Muaj ntau ntau mechanisms ntawm kev txiav txim:

• Los ntawm tshwj xeeb TNF receptors launches cov multi-theem mechanism - programmed cell tuag (kev puas ntsoog). Daim ntawv no yog hu ua ib tug cytotoxic. Nyob rau tib lub sij hawm tau pom ib tug ua kom tiav disappearance ntawm hlav, los yog txo nws loj.
• Los ntawm qhov ua txhaum cai los yog txiav ntawm lub cell voj voog. Cancer cell yuav tsis tau faib thiab lub pob loj hlob nres. Daim ntawv no yog hu ua ib tug cytostatic. Feem ntau o nyob rau tog twg los tsis ua, los yog zuj zus lawm nyob rau hauv loj.
• By thaiv cov hlab qhov txheej txheem ntawm neovascularization ntawm lub qog cov ntaub so ntswg thiab kev puas tsuaj ua ntej uas twb muaj lawm cov hlab ntsha. Lub qog deprived ntawm cov zaub mov, necrotic, decreases thiab disappears.

Muaj tej yam teeb meem nyob qhov twg mob cancer hlwb yog insensitive rau txhaj tshuaj vim change. Ces tus saum toj no mechanisms tsis tshwm sim.

Cov kev siv nyob rau hauv cov tshuaj

Pob necrosis tau yog siv nyob rau hauv lub thiaj li hu ua cytokine txoj kev kho - kev kho mob ntawm kev proteins uas yog generated los ntawm cov ntshav hlwb lub luag hauj lwm rau kev tiv thaiv. Tus txheej txheem yog tau txhua ntu ntawm lub qog txheej txheem thiab tsis contraindicated rau cov neeg uas muaj comorbidities - plawv, raum, hepatic. Yuav kom txo tau cov tshuaj muaj taug thov cov recombination mob necrosis tau.

Kev kho mob nrog cytokines - tshiab thiab progressively tsim teb ntawm Oncology. Kev siv ntawm TNF yog suav tias yog qhov zoo tshaj. Vim qhov no tshuaj yog heev tshuaj lom, nws yog siv los ntawm thiaj li hu regional perfusion. Cov kev muaj nyob rau hauv lub fact tias cov kab mob qog hloov khoom nruab nrog los yog lub cev ib feem nrog kev pab los ntawm tshwj xeeb cov khoom cawm nej dim ntawm cov kev ncig. Ces artificially ua ntshav nrog txhaj TNF.

txaus ntshai txim

Nyob rau hauv soj ntsuam xyaum, mob necrosis tau siv nrog ceev faj. Ib tug xov tooj ntawm cov kev tshawb fawb muaj pov thawj hais tias TNF - ib tug tseem ceeb feem nyob rau hauv txoj kev loj hlob ntawm sepsis, tshuaj lom poob siab. Lub xub ntiag ntawm no protein ntau zog lub pathogenicity ntawm cov kab mob thiab kab mob, uas yog tshwj xeeb tshaj yog txaus ntshai nyob rau hauv lub xub ntiag ntawm tus kab mob HIV nyob rau hauv ib tug neeg mob. Nws muaj pov thawj hais tias TNF yog muab kev koom tes nyob rau hauv yuav ua kab mob autoimmune (e.g., mob caj dab rheumatoid) nyob rau hauv uas lub cev yuam tau txais cov ntaub so ntswg thiab hlwb ntawm tus kab mob ntawm txawv teb chaws lub cev thiab kev puas tsuaj rau lawv.

Yuav kom txo tau lub siab lom nyhuv soj ntsuam cov nram qab no:

• tsuas siv cov zos nyob rau qhov chaw ntawm lub qog tsim;
• ke nrog lwm yam tshuaj;
• Lawv ua hauj lwm nrog tsawg lom mutant TNF proteins;
• muab neutralizing tshuaj.

Tej xwm txheej no yuam txwv kev siv cov qog necrosis tau. Kev kho mob lawv yuav tsum zoo-ncaav.

diagnostic qhia

Ib tug ntshav kuaj tsis ntes TNF nyob rau hauv ib tug noj qab nyob zoo lub cev. Tab sis cov theem tsub kom dramatically nyob rau hauv kis kab mob qhov twg cov ntshav los yav toxins. Ces tej zaum nws yuav tsum tam sim no nyob rau hauv cov zis. Pob necrosis tau nyob rau hauv lub synovial cov kua rheumatoid mob caj dab hais tias.

Tsis tas li ntawd kom ntawm qhov ntsuas no hais txog kev tsis haum tshuaj, cancer kab mob thiab yog ib tug kos npe rau ntawm tsis kam transplanted pub kabmob. Muaj pov thawj hais tias lub nce nyob rau qhov ntsuas no yuav qhia tias tsis yog-sib kab mob xws li mob plawv tsis ua hauj lwm, bronchial hawb pob.

Nyob rau hauv ntau yam immunodeficiency (xws li AIDS) thiab mob kab mob cov kab mob uas tshwm sim raws li raug mob thiab kub yus, tej yam kev mob yog tsim uas txo lub qog necrosis tau. Ib tug yeeb tshuaj uas muaj ib qho immunosuppressive nyhuv, muab ib tug zoo xws li cov nyhuv.

npaj

raws li nyob rau hauv TNF tshuaj hu ua tsom - muaj peev xwm ua aiming ntawm kev molecules ntawm cancer hlwb, ua rau cov tuag ntawm lub yav tas. Cov nyhuv rau lwm yam kabmob yog tsawg heev, uas thiaj li toxicity, uas muaj ib tug mob necrosis tau. raws li cov tshuaj yog siv raws li ib tug TNF nyob ib leeg (monotherapy) thiab combining nrog lwm cov neeg ua hauj.

Niaj hnub no muaj ntau cov khoom rau lub hauv paus ntawm TNF, namely:

• NGR-TNF - teb chaws cov khoom, lub active khoom sib ua zaub mov yog ib tug derivative ntawm lub TNF. Nws yog tau puas rau cov hlab ntsha ntawm lub qog, depriving nws ntawm nws lub hwj chim.
• "Alnorin" - Lavxias teb sab kev loj hlob. Nws yog zoo heev nyob rau hauv ua ke nrog nrog interferons.

"Refnot" - Russia tus tshiab tshuaj uas muaj mob necrosis ceeb thiab thymosin alpha 1. Nws toxicity yog heev tsawg, tab sis cov ua hauj lwm zoo yog sib npaug zos rau lub ntuj TNF, thiab txawm ntau tshaj nws los ntawm ib tug immunostimulatory kev txiav txim. Cov tshuaj yog tsim nyob rau hauv 1990. Nws tau ntse dhau tag nrho cov tsim nyog raug soj ntsuam thiab tsuas yog nyob rau hauv 2009 tau kaw, uas tau muab hauj kev tso cai los kho lawv cov qog nqaij hlav.

Self-thawj coj ntawm tag nrho cov tshuaj nyob rau hauv lub hauv paus ntawm lub qog necrosis tau kiag li txwv tsis pub. Cancer kev kho mob - mas lub koom haum uas yuav siv sij hawm qhov chaw heev dua lwm yam nyob rau hauv lub saib xyuas ntawm ib tug tshwj xeeb.