"Pipekuroniyu bromide": cov lus qhia rau kev siv

Tshuaj relaxing skeletal leeg, yog lug siv tsis tau tsuas yog thaum lub sij hawm kev phais cov txheej txheem ntawm nruab nrab thiab ntev ntev, tab sis kuj nyob rau hauv txoj kev xyaum ntawm kev poob plig nrog lub aim ntawm repositioning los yog prosthetic pob qij txha. "Pipekuroniyu bromide" yog hais txog cov pab pawg neeg antidepolyarizuyuschih hnaiv thiab muaj ib tug tshaj plaws ntev ntawm kev txiav txim ntawm 50-70 feeb nyob rau tus yam ntxwv ntawm tus kab mob. Cia peb xav txog cov lus qhia rau kev siv ntawm cov tshuaj, thiab tshwj xeeb tshaj yog nws cov kev siv nyob rau hauv kev ua kom loog xyaum.

pharmacological characterization

Lub mechanism ntawm qhov kev txiav txim ntawm cov tshuaj txuam nrog thaiv cov hlab synaptic kis tau tus mob nyob rau neuromuscular synapse. Vim li no, muaj yog inhibition ntawm qhov tshwm sim ntawm qhov kev txiav txim tej zaum nyob rau hauv cov nqaij fiber membrane, thiab yog li, cov nqaij cell loses nws muaj peev xwm mus ua ntawv cog lus.

Nrog heev raug rau cov tshuaj conditionally "pipekuroniyu bromide" skeletal musculature relaxes. Muab hais tias nicotinic cholinergic receptors ntawm lub hom nyob tsis tau tsuas yog nyob rau hauv cov kev sib cuag cheeb tsam ntawm efferent fibers Somatic tshee system nrog lub mob hlwb ntawm skeletal nqaij thiab ganglia nyob rau hauv lub autonomic lub paj hlwb, cov kev taw qhia ntawm loj koob tshuaj medicament tshwm sim los ganglioblokiruyuschimi tsis muaj zog nyhuv. Qhov no yog vim lub cessation ntawm cov kis ntawm cov hlab impulse mus rau lub postsynaptic daim nyias nyias ntawm neurons, uas ua rau yus mus rau ib tug txo nyob rau hauv ob qho tib si sympathetic thiab parasympathetic los.

indications

Kev npaj "pipekuroniyu bromide" yog qhia rau cov so ntawm skeletal nqaij thaum phais. Zoo ntawm cov tshuaj rau lub hom phiaj ntawm tracheal intubation nrog cov neeg kho tshuab cua.

Contraindications

Raws li cov tshuaj rau "pipekuroniyu bromide" kev qhia ntawv, cov tshuaj no yog kiag li txhob nyob rau hauv lub xub ntiag ntawm npau taws me ntsis thiab nyob rau hauv lub xub ntiag ntawm myasthenia (muaj tsawg heev, txhob txiav txim tus kab mob, uas yog nyob rau hauv yuam cai ntawm lub excitation ntawm lub neuromuscular synapse txoj kev loj hlob thiab leeg tsis muaj zog).

Cov tshuaj yog ua rau cov neeg mob nyob rau hauv thaum ntxov ua sawv ntawm cev xeeb tub. Nyob rau hauv lub tom qab ua sawv ntawm cov tshuaj yuav tsum tau siv, raws li nws crosses tus placental barrier nyob rau hauv me nyiaj.

phiv

Cov tshuaj yuav inhibit qhov kev ua ntawm lub hauv paus poob siab system, ua rau meem kev txhawj xeeb tshwm sim.

Los ntawm cov sab ntawm cov hlab plawv tus sab los tshwm sim los ntawm inhibition ntawm cholinergic kis tau tus mob nyob rau synapses. Ua li ntawd tej zaum yuav txo lub plawv dhia, txo cov ntshav siab, ischemic heart attack myocardial raug mob, hlwb puas txuam nrog poob perfusion.

Thaum raug tau kev nyuaj siab ntawm lub pa system ntawm lub pa muaj nuj nqi, qhov tshwm sim ntawm apnea los yog apnea (tshwj xeeb tshaj yog thaum lub sij hawm aftereffects ntawm cov tshuaj).

Cov tshuaj muaj feem xyuam rau cov metabolism thiab muaj peev xwm mus ua ib qho kev nce rau hauv cov ntshav potassium theem, ua rau cov theem ntawm endogenous creatinine thiab qis ntshav qab zib theem.

Tshuaj "pipekuroniyu bromide" - cov lus qhia rau kev siv

Lub tshuaj no yog muab tsuas nyob rau hauv lub saib xyuas ntawm ib tug tshwj xeeb. Ua ntej tshuaj thawj coj yuav tsum xyuas cov nyob rau ntawm anticholinesterases ( "Neostegmina" los yog "Pyridostigmine") los yog anticholinergics ( "Atropine").

Tom qab lub manipulation nruam neeg mob xyuas yog nqa tawm thaum lub sij hawm rov qab lub sij hawm tom qab tshuaj loog thiab tus neeg mob mus normalize nqaij laus.

Cov tshuaj ntawm medicament rau lub hauv paus ntawm txoj kev soj ntsuam ntawm tus neeg mob thiab kev tshawb fawb cov ntaub ntawv tsom xam kuaj hom kev kawm. Nyob rau hauv lub xub ntiag ntawm ua hauj lwm ntawm lub raum excretory muaj nuj nqi, kev siab tsis ua hauj lwm, cov rog - koob tshuaj yuav tsum tau sab medicament.

Cov tshuaj yog npaj tam sim ntawd ua ntej cov tshuaj thawj coj "pipekuroniyu bromide." Daim ntawv tshuaj tawm - vials ntawm lyophilized hmoov uas muaj 0.004 g ntawm active tshuaj.

Rau cov neeg mob nrog impaired cov ntshav ntsha tshuav nyiaj li cas thiab cov kua qaub-puag tshuav nyiaj li cas no kuj yuav tsum tau txhaj koob tshuaj haum. Preferential yuav txo tau ntawm ion concentration nyob rau hauv cov ntshav ntshav, hypothermia thiab siv cov mob glycosides (thaum lub sij hawm digitalization) yog tau lengthen lub caij ntawm yeeb tshuaj. Nyob rau hauv cov ntaub ntawv ntawm nqaij so nyob rau hauv pab pawg neeg no ntawm cov neeg mob chiv yuav tsum normalize lub ntsha ntawm cov ntshav, thiab ces mus nqa tawm nqaij so. Nyob rau hauv cov ntaub ntawv ntawm cov neeg mob uas mob hauv lub plawv tsis ua hauj lwm, ntshav yuav qeeb tus extension ntawm lub latent lub sij hawm ntawm kev siv yeeb tshuaj nyhuv (nce nyob rau hauv lub sij hawm ntawm kev tswj hwm thiab pib ntawm nyhuv).

Koj siv tau cov tshuaj nyob rau hauv cov me nyuam los ntawm 1 lub xyoo. Nyob rau hauv cov ntaub ntawv no nws yuav tsum tau nco ntsoov tias tus me nyuam lub cev yog tsawg rhiab rau cov teebmeem ntawm cov nqaij relaxant, thiab raws li, mus cuag cov nyhuv, cov tshuaj ntawm cov tshuaj yuav tsum tau nce.

So cov tshuaj

Muab cov tshuaj rau "pipekuroniyu bromide" daim ntawv qhia nyob rau hauv Latin yuav tsis txawm tus kws kho mob. Lub tsev kho mob tau txais lub hwj chim tshuaj los ntawm daim ntawv teev A xwb nyob rau kev thov thiab nyob rau hauv lub hauv paus ntawm lub xeev. Nyob rau hauv ib tug nyias muaj nyias ib cov ntaub ntawv, "pipekuroniyu bromide" daim ntawv qhia tej zaum yuav muab ib tug kws muaj txuj siv lub "liab" daim ntawv no, Txawm li cas los, tsis yog txhua txhua lub tsev kho mob network yeej muaj cai tau realization ntawm cov tshuaj thiab nyuaj tshuaj, xws li nqaij hnaiv.

pauv npe

Nyob rau hauv lub chaw ua tshuaj ua lag luam cov tshuaj muaj nyob rau hauv xws pauv npe raws li "Arduan" "Vero pipekuroniyu", "Aperamid", "pipekuroniyu bromide." Trade lub npe ntawm cov tshuaj yog nyob rau hauv lub chaw tsim tshuaj paus, muab ib tug yeeb tshuaj mus rau lub chaw ua tshuaj ua lag luam.

overdose

Ib tug overdose ntawm cov tshuaj thiab cov yuav txo tau cov nyhuv yog tau vim cov kev taw qhia ntawm anticholinesterases. Cov tshuaj pab tau kom lub concentration ntawm neurotransmitter acetylcholine, li no sib tw nrog nqaij relaxant rau cov thwj toob qhov chaw hauv receptor.

Tsis tas li ntawd, kho ntsuas nyob rau hauv overdose tsim los kom cov ntshav siab, muaj tseem ceeb heev lub cev functions, nrog rau ntawm cov nuj nqis ntawm cov neeg kho tshuab cua.

Tshuaj kev sib tshuam

Cov tshuaj yuav tsis tau tov nrog txawv Txoj kev lis ntshav dlaws, tsuas yog isotonic kev daws teeb meem ntawm sodium tshuaj dawb thiab dextrose. Cov kev loj hlob ntawm cov tshuaj nyhuv slows, lub zoo tshuaj txhaj koob tshuaj yog nce nyob rau hauv lub zwj ceeb ntawm preoperative thawj coj mus rau ib tug neeg mob lub cholinesterase inhibitors.

Nyob rau hauv ib tug sib koom daim ntawv thov nrog rau cov nqaij relaxant narcotic analgesics tau kev nyuaj siab ntawm lub pa chaw nrog txoj kev loj hlob ntawm cov pw tsaug zog apnea.

Siv cov tshuaj noj depolarizing nqaij hnaiv hom ntawm kev txiav txim yuav ob leeg txhim khu thiab tsis tau lub zuag qhia tag nrho cov leeg relaxant nyhuv. Qhov no teeb meem yog vim ntau npaum ntawm cov tshuaj, lub sij hawm ntawm cov thawj coj, thiab ib tug neeg rhiab heev mus rau yeeb tshuaj.

xaus

Nqa nqaij so thaum phais - ib tug tseem ceeb ib feem ntawm ib tug kev tshuaj loog. Tshuaj "pipekuroniyu bromide" yog ntse siv nyob rau hauv kev kho mob xyaum rau cov hom phiaj.

Nws yuav tsum tau nco ntsoov tias cov kev taw qhia ntawm cov tshuaj tsis tau tsuas yog ua rau ib ce xoob ntawm skeletal nqaij lub luag hauj lwm rau kev txaus siab zog, tab sis kuj ua rau tuag tes tuag taw ntawm lub pa nqaij. Xav li no, cov tshuaj no yog siv tsuas nyob rau hauv tej yam kev mob thiab kev phais intensive kev saib xyuas chav nyob.