Phosphatidic acid. Synthesis thiab tseem ceeb nyob rau hauv lub cev

Los ntawm qhov seem yus pom ntawm tshuaj qauv, phosphatidic acid yog qhov nyuaj phospholipid.

Qhov no tshuaj yog ib tug ntawm cov milestones ntawm phosphoglycerides metabolism hauv vivo.

Qhov no hauv chav kawm ntawv ntawm tshuaj yog muab ntau xim nyob rau hauv txoj kev tshawb no ntawm lub teeb liab zog tshuaj tebchaw.

Rau hnub tim, mus txog rau lub xaus tsis meej tag nrho cov kev mus nyob rau hauv lub metabolism ntawm phosphatidic acids, nyob rau hauv particular, yog tseem xam tau tias yog rau lo lus nug ntawm lub mechanism ntawm lub teeb liab kis tau tus mob cov ntaub ntawv sib txuas, zoo li hais txog lub xub ntiag ntawm phosphatidic acids ionophoric zog.

Synthesis of phosphatidic acid

Phosphatidic acid tsim yog los ntawm phospholipase D. Qhov no hauv chav kawm ntawv ntawm enzymes muaj ib tug leading luag hauj lwm nyob rau hauv lub synthesis ntawm phosphatidic acids. Raws li ib tug raug luv luv-lived tshuaj compound, tom qab lub substance nyob rau hauv tus fosfogidrolazy hydrolysed rau diglyceride (los ntawm cov tshuaj tiv thaiv dephosphorylation).

Thaum interacting nrog cov tib enzyme phosphatidic acid yuav hloov thiab diacylglycerol, uas ua ib lub voj voog ntawm biochemical kev tig cev activator muaj nuj nqi ntawm lub enzyme protein kinase C.

Synthesis of phosphatidic acid tshwm sim nyob rau hauv cov ntaub so ntswg adipose. Cov txheej txheem yuav pib nrog qhov tau txais tsab nyob rau hauv adipocytes (adipose cov nqaij mos hlwb) fatty acids tsim nyob rau hauv lub hydrolysis ntawm cov nqaijrog (mas, tsis tshua muaj heev ceev lipoproteins). Hauv lub cell, interacting nrog glycerol-tri-phosphate, fatty acids uas yog hloov dua siab tshiab ua ntej mus lysophosphatidic acid, uas los ntawm lub tom qab tsim phosphatidic acid.

Formula tsim therefrom phosphoric glycerophospholipids muaj seem ntawm fatty acids, glycerol, thiab nitrogen-muaj anions.

Lub ntsiab lus ntawm phosphatidic acid

Nws pom hais tias lub phosphatidic acid yog ib tug thiaj li hu ua taw sib txuas, uas yog, cov neeg uas yog ib tug muaj nuj nqi ntawm intermediaries nyob rau hauv cov kis ntawm cov ntaub ntawv nyob rau hauv lub signaling txoj. Nyob rau hauv kev, nws yog ib tug tseem ceeb link nyob rau hauv cov kis ntawm cov Pib ntsais koj teeb nyob rau hauv cog hlwb:

• cytokinin;
• osmotic uas muaj ib tug nqi nyob rau hauv txoj kev loj hlob ntawm ib tug cellular lo lus teb rau qhov no zoo ntawm kev nyuaj siab.

Thaum lub sij hawm thwmsim nws twb pom tau tias cov theem ntawm compound nyob rau hauv lub hlwb raug tsob nroj kab mob pathogenic yam tsub kom ho. Qhov no cov tshuaj tiv thaiv ua rau:

• Osmotic kev nyuaj siab.
• Tsis tshua muaj kub.
• Cov nyhuv ntawm tej active cov khoom xyaw muaj ib tug zaub keeb kwm (phytohormones).

Yog li, nws yuav tsum xaus lus rau qhov kev koom tes ntawm phosphatidic acid thiab nws cov metabolites nyob rau hauv txoj kev tshua lub luag hauj lwm rau adaptation ntawm tus kab mob rau stressful lub sijhawm.

Tsis tas li ntawd, nws yog lub npe hu hais tias lub phosphatidic acid yog ib qho tseem ceeb rau cov thauj ntawm protons thiab cov tshuaj tiv thaiv ntawm calcium ions los ntawm cov daim nyias nyias ntawm neurons thiab nqaij fibers. Raws li, phosphatidic acid thiab kuj ascribe muaj nuj nqi ionophore (xaiv: rau calcium ions thiab protons).

transduction mechanism

Txawm hais tias lub hom phiaj ntawm phosphatidic acid nyob ncaj qha rau txoj kev (mechanism) ntawm lub teeb liab kis tau tus mob yog tseem debated thiab yuav tsum tau specification.

Txawm li cas los muaj tsis muaj tsis ntseeg tias cov transduction yog nqa tawm ua tsaug rau cov muaj peev xwm ntawm phosphatidic acid, rau cov cellular qauv ntawm daim nyias nyias, daim nyias nyias tswj cov kev ua ntawm enzymes, thiab kuj koom nyob rau hauv lub sis raug zoo nrog cov cellular membrane protein molecules.

Daim ntawv thov ntawm phosphatidic acid

Kev tshawb fawb muaj antioxidant kev ua ntawm derivatives ntawm phosphatidic acid, ua raws li nyob rau hauv txoj kev tshawb no ntawm cov qauv txheej txheem thiab uas lom khoom tau qhia tias yog li ntawd-hu ua phosphatidic acid mimetics muaj antioxidant plurality ntawm mechanisms ntawm kev txiav txim.

Comprehensive ntaub ntawv nyob rau hauv cov kev taw qhia ntawm kev txiav txim ntawm phosphatidic acid tso cai rau kom siv nws thiab nws cov metabolites nyob rau hauv qhuav ntawm biologically active tshuaj tsim los txhim khu kev ua tau zoo thiab ua siab ntev thev ntawm lub hlwb.

Ua raws cov cellular theem, xws tebchaw tsis pom, tiam sis tsuas yog normalize lub hlwb; qhov tseem ceeb point yog los txo cov kev pheej hmoo ntawm tsis phiv.