"Pharmadipin" (tee) los ntawm dab tsi?

Tam sim no, muaj ntau ntau yam tshuaj los ntawm kev kub ntxhov thiab angina tawm tsam. Ib qho ntawm lawv kuj yog "Pharmadipin" (tshuaj). Los ntawm dab tsi no siv tshuaj yaj yeeb, peb yuav xav txog ntxiv nyob rau hauv ntau dua kom meej.

Muaj pes tsawg leeg

Lub active muaj nyob rau hauv cov ntaub ntawv no yog nifedipine (nifedipine). Nyob rau hauv 1 ml ntawm no tov, nws yog nyob rau hauv ib tug tej tus nqi. Namely, thaum recalculating los ntawm 100%, cov hom tshuaj qhuav yog 20 mg. Pebcaug tee yog tau.

"Pharmadipin" (cov tshuaj), cov kev qhia rau kev siv rau hauv kev sib tham hauv qab no, muaj hauv nws qhov kev kuaj pom muaj cov khoom pab li polyethylene glycol 400 thiab ethanol 96%.

Pharmacological zog

Cov tshuaj no muaj hom tshuaj pharmacodynamics. Raws li twb tau hais los saum no, "Pharmadipin" (cov tshuaj) muaj cov tshuaj nifedipine, uas ua rau cov tshuaj antihypertensive thiab cov tshuaj tiv thaiv kev ua kom raug. Nws pab thaiv qhov nkag ntawm calcium ions mus rau hauv cardiomyocytes thiab mus rau hauv tej lub hlwb pob txha ntawm peripheral thiab coronary leeg los ntawm kev muaj peev xwm-nyob qis sib qeeb sib tshooj ntawm cov xovtooj ntawm lub cev. Qhov no yog ib qho tseem ceeb heev. Nifedipine kuj muaj so ntawm vascular du nqaij, nce peripheral thiab coronary hlab ntsha, cov tshem tawm ntawm chua. Qhov no txo cov ntshav siab, OPSS, postnagruzka rau ntawm lub plawv thiab cov pa xav tau ntawm myocardium. Tsis tas li, thaum noj cov tshuaj no, tej yam tshwm sim kuj tseem pom. Namely, muaj yog ib tug me ntsis txo nyob rau hauv myocardial contractility thiab lub plawv muaj nuj nqi, raws li zoo raws li dog dig txo platelet aggregation.

Pharmacokinetics

Hauv no hais txog, "Pharmadipin" (tee), cov kev qhia rau kev siv ntawm qhov kev ntsuam xyuas no, nws muaj nws tus yam ntxwv. Nrog sab nrauv txais, nws yog absorbed zoo nyob rau hauv lub hnyuv. Nws cov bioavailability yog li 40-60 feem pua. Txoj kev loj hlob sai (tom qab 5-10 feeb) yog pom thaum sublingual thawj coj. Qhov no tseem ceeb heev kom paub. Feem ntau qhov loj tshaj cov nyhuv yog tshwm sim tom qab 30-40 feeb. Kev qoj ib ce ntawm kev noj zaub mov tsis zoo tshwj xeeb rau qhov kev nqus ntawm qhov tshuaj no. Qhov tshwm sim ntawm hemodynamic nyhuv yuav mob siab rau 4-6 teev. Mus txog 90 feem pua ntawm nifedipine khi rau ntshav cov ntshav proteins. Metabolized xws li yeeb tshuaj raws li "Pharmadipin" (tee), nyob hauv siab. Qhov ncaim tag nrho ntawm nifedipine yog los ntawm 0.4 mus rau 0.6 l / kg / h. Nws yog tawm los ntawm lub cev tsuas yog nyob rau hauv daim ntawv ntawm metabolites ntawm lub hom tsis tuaj. Ib nrab ntawm lub neej yuav los ntawm 2 mus rau 4 xuab moos. Nyob hauv cov neeg laus thiab cov neeg mob uas muaj cirrhosis, cov metabolism hauv nifedipine ho yau dua. Yog li, lawv muaj qhov qhia txog ntawm ib nrab ntawm lub neej ntawm cov tshuaj no yuav nce li ntawm 2 zaug. Hauv qhov no, nws yuav tsum tau txo cov koob tshuaj thiab kom cov kev sib hloov ntawm cov thawj coj ntawm kev npaj los ntawm qhov kev npaj no. Nifedipine nyob rau hauv lub cev tsis yog cumulated. Tsis tas li ntawd, me me xwb, nws muaj peev xwm nkag mus rau hauv plab thiab tso ntshav siab. Hauv qhov no, nws tawm hauv niam mis.

Cov kev qhia rau kev siv

Muab cov "Pharmadipin" (cov tshuaj) tso rau hauv cov nram qab no:

• Thaum muaj ib qho tseem ceeb thiab mob ntsig txog ntshav siab.
• Rau kev kho thiab kev tiv thaiv ntawm stenocardia tawm tsam.
• Nrog kev mob plawv mob cancer.
• Nrog Raynaud tus kab mob.

Daim ntawv thov

Nqa "Pharmadipin" (tee) sublingually. Nrog rau qhov nce siab ntawm ntshav siab (piv txwv li, 180 / 100-190 / 110 hli Hg), thawj zaug tshuaj ntawm cov tshuaj no rau cov laus siv li 3-5 poob (2-3.35 mg). Cov neeg mob uas advanced muaj hnub nyoog yog tseem muab ib tug kev tshuaj. Namely - tsis pub ntau tshaj 3 tee (li 2 mg). Tsis tas li ntawd, cov nyiaj no muaj peev xwm muab faib rau ib qho me me ntawm breadcrumbs los yog qab zib. Nws tus neeg mob yuav tsum kom ntev li ntev tau ntawm nws lub qhov ncauj. Yog tias cov txiaj ntsig tsis txaus, qhov kev siv cov tshuaj no ntau zuj zus mus rau kev kho mob. Hauv qhov no, txhua yam nyob ntawm tus neeg mus kom ze. Ntawm cov kev tshwm sim tom qab ntawm qhov nce hauv ntshav siab yuav tsum tau ua kom meej rau cov tshuaj uas tau muab qhia. Tseem tshuav ib qho ntxiv. Nws nyob hauv qhov tseeb tias yog tias ntshav siab nce mus txog 190 / 100-220 / 110 hli Hg. Lub txais tos ntawm tee ntawm no npaj yuav maj mam nce mus rau 10-15 (6.7-10 mg). Qhov no yuav tsum coj mus rau hauv tus account lub siab hloov nyob rau hauv ib tug neeg mob. Qhov no tseem ceeb heev kom paub.

Nws tseem yog ib qho tseem ceeb uas yuav tsum tau coj mus rau hauv tus account muaj qhov mob ntawm ib txhia neeg mob mus rau ib qho tshuaj xws li "Pharmadipin" (tee), qhov kev kuaj xyuas yog qhov zoo. Nyob rau hauv cov rooj plaub no, cov tshuaj tsuas xaiv ib tus zuj zus. Pib nrog 3 tee, thiab tom qab ntawd maj mam nce zus los ntawm 2-3 (1.34-2 mg) kom txog thaum lub sij hawm thaum lub sij hawm tsim nyog siv tshuaj.

Nws yuav tsum nco ntsoov tias yog thawj koob tshuaj ntawm cov tshuaj no ntau tshaj, txo cov ntshav siab tuaj yeem tshwm sim!

Sab nyhuv

Thaum siv cov tshuaj xws li "Pharmadipin" (dauv ntawm lub siab), tej zaum yuav muaj kev xeev siab, tachycardia, mob ntshav siab, "tides" rau ntawm cov ntshav. Qee zaum, qhov tshwm sim ntawm kev tsis haum tshuaj nyob rau hauv daim ntawv ntawm edema ntawm tus taw, qhov nqaij pob liab liab. Cov tsos mob ntawm kev qaug zog, kiv taub hau, mob taub hau kuj yuav tshwm sim.

Contraindications

Kev tso npe ntawm ib yam tshuaj xws li "Pharmadipin" (mob) yog raug txwv tsis pub muaj kev puas tsuaj rau nws lub cev, mob plawv tsis zoo, mob aortic thiab mitral stenosis, hypotension, tachycardia, thiab thaum lub sijhawm pub mis thiab cev xeeb tub.

Overdose

Hauv qhov no, qee cov tsos mob tsis zoo yuav tshwm sim. Namely overdose ntawm xws cov tshuaj raws li "Farmadipin" (dauv), yuav tsum tau nrog los ntawm qhov tshwm sim ntawm lub plawv tsis ua hauj lwm, poob siab, metabolic acidosis thiab convulsions, ib tug ntse poob nyob rau hauv cov ntshav siab. Thaum cov tsos mob tshwm sim no, nws yog ib qho tseem ceeb uas yuav tau tuaj yeem tiv thaiv qee qhov kev ntsuas ntawm kev saib xyuas. Lawv muaj xws li ntxuav lub plab, noj cov tshuaj ntsuab, ua cov tshuaj calcium thiab sympathomimetics, symptomatic therapy.

Ntaus siv

"Pharmadipin" (dauv ntawm lub siab) los yog kev hloov rau nws yuav tsum tsuas yog siv nrog kev soj ntsuam kom soj ntsuam cov neeg mob uas muaj hnub nyoog siab tshaj thiab cov neeg mob uas muaj:

- Tsis ruaj tsis khov.

- Qhia tawm lub plawv tsis ua haujlwm.

Hypertrophic cardiomyopathy.

- Mob aortic stenosis.

- Mob ntshav siab heev.

- Mob ntshawv siab ntawm ntshav khiav ntawm lub hlwb.

- Mob ntshav qab zib mellitus.

- Feem ntau ntawm ob lub raum thiab siab.

Siv lwm cov tshuaj uas siv nrog nifedipine, yuav tsum muab ntsia ib tus zuj zus. Plawv glycosides kuj yuav siv thaum lub sij hawm txais tos ntawm xws tshuaj raws li "Farmadipin" (dauv), analogs uas muaj qhia hauv qab no nyob rau hauv phau ntawv no.

Thaum noj cov tshuaj nifedipine nrog cov tib neeg siv cov tshuaj intravenous magnesium sulfate, cov poj niam cev xeeb tub yuav tsum tau soj ntsuam xyuas ntshav siab. Qhov no yuav tsum tau ua vim hais tias muaj ib qho kev txo qis ntshav siab, uas yuav ua mob rau leej niam thiab tus me nyuam hauv plab.

Cov neeg mob uas ua rau lub siab ua haujlwm kuj yuav tsum tau saib xyuas zoo. Nyob rau hauv loj heev zaus, lub koob tshuaj yuav tsum tau txo.

Nifedipine metabolised los ntawm cytochrome system P450 3A4. Yog li ntawd, cov kev npaj uas ua rau tsis zoo los yog ntxias cov cheeb tsam no enzyme yuav hloov cov nyhuv ntawm "thawj tshooj" los yog qhov tseeb ntawm cov khoom. Nrog txoj kev siv cov tshuaj nifedipine nrog cov tshuaj no, koj yuav tsum saib ntshav siab. Yog tias tsim nyog, nws yog qhov tsim nyog rau kev tsim kho kom txo cov tshuaj ntawm qhov yeeb tshuaj li "Pharmadipin" (tee).

Ua cais thwmsim nyob rau hauv vitro tau qhia ib tug kev sib raug zoo ntawm txoj kev siv cov calcium antagonists nyob rau hauv cov ntaub ntawv no nifedipine thiab biochemical rov qab spermatozoa hloov rau lub deterioration ntawm lub peev xwm ntawm lub yav tas los siv fertilization.

Noj tshuaj "Pharmadipin" (tshuaj), koj yuav tsum tsis txhob cuam tshuam los ntawm cov dej num ntawm ib hom kev phom sij, uas yuav tsum tau hnov ntau dua. Namely, nws tsis tsim nyog rau tsav tsheb, ua haujlwm nrog lwm cov tswv yim thiab ua li ntawd.

Kev sib tham

"Pharmadipin" (tee) muaj cov nyhuv tshuaj phem. Cov cuab yeej no muaj txiaj ntsim rau txoj kev khov kho ntawm cov yeeb tshuaj ntawm pawg ntawm blockers. Qhov no yog, "Pharmadipin" (teeos) ua rau cov neeg muaj mob hu ua β-adrenoreceptors, diuretics, nitrates, lwm yam tshuaj tua kab mob, tshuaj thiab dej haus cawv, tricyclic antidepressants. Qee zaum, nifedipine txo cov concentration ntawm quinidine hauv ntshav ntshav. Tab sis qhov tshem tawm ntawm nws tshuam tsub kom nws. Yog li, siv chav kho mob ua ke, nws raug pom zoo los soj ntsuam cov theem ntawm quinidine concentration hauv ntshav ntshav.

"Diltiazem" txo cov kev haus ntawm cov tshuaj xws li "Pharmadipin" (tee). "Fentanyl" significantly nce qhov tshwm sim ntawm cov nyhuv hypotensive. Yog li, ua ntej kev qhia txog cov tshuaj no (rau tsawg dua 36 teev), koj yuav tsum tsis txhob noj cov "Pharmadipin". Kev sib koom siv cov β-blockers nrog nifedipine tuaj yeem ua rau kev txhawj xeeb ntawm hypotension. "Pharmadipin" (mob ntses) yuav pab kom cov concentration of theophylline, carbamazepine thiab digoxin nyob rau hauv cov ntshav. "Rifampicin" ua rau lub zog ntawm kev kho mob nifedipine, thaum lub zog ua kom tiav ntawm nws cov metabolism. "Cimetidine" yuav pab kom lub cev muaj zog ntawm "Pharmadipin" hauv cov ntshav ntshav.

Cov ntsiab lus thiab tej yam kev mob ntawm kev cia

Hauv qhov no, muaj qee qhov kev ntsuas. Khaws "Pharmadipin" (tee) nyob rau hauv ib qho chaw qhuav ntawm chav sov. Cov tshuaj yuav tsum muaj kev tiv thaiv ntawm lub teeb thiab tsis cuag cov menyuam yaus. Cia ntawm cov tshuaj no yog tsim los mus txog 1 xyoos thiab 6 lub hlis. Tom qab lub vial yog qhib - 28 hnub.

Kev so

"Pharmadipin" (tshuaj) yog muag tshwj xeeb heev los ntawm cov tshuaj.

Ntim

Hauv vials ntawm 25 ml los yog 5 ml. Lawv muab ntim rau hauv ib pob.

"Pharmadipin" (tee): cov analogues hauv Russia

Muaj ntau ntau qhov kev hloov rau cov tshuaj no. Cov tseem ceeb yog:

"Cordypin."

"Nifedipine."

"Adalat."

- "Cordaflex".

- "Corinfar Uno."

- "Cordaflex RD".

- "Fenigidine."

- Osmo-adalat.

"Cordipin retard."

- "Cordyxin xl".

Xaus

Tam sim no koj paub tias yam tshuaj zoo li "Pharmadipin" (tee) yog, nws pab dab tsi thiab seb nws muaj khoom zoo li cas. Nyob rau hauv txhua rooj plaub, ua ntej koj noj cov tshuaj no, nrog tus kws kho mob uas tsim nyog tham.