Los ntawm dab tsi pab "Nise" (ntsiav tshuaj)? Cov lus qhia rau kev siv, analogs

Yog koj paub txog dab tsi ua rau "Nise" (ntsiav tshuaj)? Yog hais tias tej ntaub ntawv koj tsis muaj, ces peb yuav nthuav nws nyob rau hauv cov ntaub ntawv ntawm qhov tsab xov xwm.

Ntim khoom thiab nws muaj pes tsawg leeg

Qhov tseeb ntawm yog dab tsi ua rau "Nise" (ntsiav tshuaj), peb piav qhia txog nram qab no. Lub active muaj nyob rau hauv cov tshuaj no yog nimesulide. Tsis tas li ntawd nyob rau hauv cov qauv, nws muaj xws li Cheebtsam xws li microcrystalline cellulose, aspartame, calcium phosphate, colloidal silicon dioxide, pob kws starch, magnesium stearate, sodium carboxymethyl starch, talc thiab txiv puv luj tsw.

Nyob rau hauv lub qhov muag ntawm xam tau tias yog medicament mus rau lub hlwv 10 ntsiav tshuaj, ntim rau hauv cov duab los qhia thawv.

Lub hauv paus ntsiab lus ntawm kev txiav txim ntawm cov tshuaj

Ua ntej teb cov lus nug ntawm yog dab tsi ua rau "Nise" (ntsiav tshuaj), koj yuav tsum tau qhia rau peb yuav ua li cas cov tshuaj ua hauj lwm.

Raws li cov lus qhia, nws narcotics yuav muab hais tias xaiv cheeb COX-2, uas yog ib qho enzyme muab kev koom tes nyob rau hauv synthesis ntawm prostaglandins - kev sib kho ntawm kev mob, o thiab edema. Tsis tas li ntawd anti-inflammatory zog, xam tau tias yog cov tshuaj teev analgesic thiab antipyretic kev txiav txim.

Peb tsis tau hais tias cov tshuaj cheeb qhov uas cov (reversible) tsim ntawm prostaglandin E2 nyob rau hauv lub ascending nociceptive txoj system thiab lub cheeb tsam ntawm o, raws li zoo raws li nyob rau hauv txoj kev ntawm conduction ntawm impulses (mob) nyob rau hauv cov leeg nrob qaum.

Kev npaj "Naiz" analogs uas muaj li nram no, thiaj li muaj cov concentration ntawm prostaglandin H2 (short-lived), los ntawm uas, nyob rau hauv tus ntawm prostaglandin isomerase, muaj prostaglandin E2. Txo cov concentration ntawm lub yav tas ua rau ib tug txo nyob rau hauv lub degree ntawm kom ntawm receptor-hom ER (prostanoid), uas yog qhia nyob rau hauv inflammatory thiab analgesic los.

Nws yuav tsum raug sau tseg hais tias ib tug me raws li cov tshuaj muaj feem xyuam rau qhov suav hais tias COX-1. Nyob rau hauv physiological tej yam kev mob, nws tsis yog yuav tiv thaiv prostaglandin E2 los ntawm arachidonic acid. Qhov no thiaj li tus naj npawb ntawm cov nyom tshuaj tej xwm txheej.

Lub ntsiab thaj chaw ntawm cov tshuaj (NSAID)

Kev npaj "Naiz" muaj peev xwm inhibit platelet aggregation. Qhov no tshwm sim los ntawm inhibiting lub synthesis ntawm thromboxane A2 thiab endoperoxides. Nyob rau hauv tas li ntawd, nws suppresses histamine tso tawm cov txheej txheem, thiab kuj thiaj li cov neeg kawm ntawv ntawm bronchoconstriction, uas yog tshwm sim los raug tus kab mob rau acetaldehyde thiab histamine.

Tshwj xeeb tau muaj pov thawj hais tias ib tug zoo nimesulide cheeb qhov uas cov synthesis ntawm urokinase thiab IL-6, tiv thaiv kev puas tsuaj rau cov pob txha mos. Ntxiv mus, nws cheeb qhov uas cov synthesis ntawm metalloproteases, tiv thaiv kev puas tsuaj ntawm collagen thiab proteoglycans.

Raws li cov lus qhia, los ntawm kev txo cov kev ua ntawm myeloperoxidase nyob rau hauv kev saib xyuas tshuaj exhibits antioxidant zog thiab cheeb qhov uas cov tsim ntawm cov khoom (toxic) lwj O _2. Nws ua num ua ke nrog lub glucocorticoid receptors thiab activates lawv, uas muaj txhawb mus rau lub anti-inflammatory kev txiav txim.

Lub kinetics ntawm yeeb tshuaj

Tom qab qhov ncauj analgesic "Nise" yog absorbed los ntawm cov hnyuv. Khoom noj khoom haus kom tsawg thiaj li muaj qhov tus nqi ntawm haum ntawm cov tshuaj, tiam sis tsis muaj kev cuam tshuam nws qhov twg.

Ncov ntshav ntawm nimesulide tiav tom qab 2.6 teev. Nws lub koom haum nrog ib tug protein nce mus txog 95%.

Qhov no tshuaj penetrates mus rau hauv tag nrho cov ntaub so ntswg poj niam genitals. Tsis tas li ntawd, nws yog pom nyob rau hauv ib tug acidic nruab nrab focal o thiab synovial cov kua.

Nimesulide metabolism hauv lub siab. Nws ib nrab-lub neej yog 5 teev. Nws tso tawm kom pom nyob rau hauv lub ob lub raum, raws li tau zoo raws li ua ke nrog bile.

Indications rau lozenges

Los ntawm dab tsi pab "Nise" (ntsiav tshuaj)? Ntawm cov nyiaj tshuaj rau:

• sciatica, mob caj dab rheumatoid, sciatica;
• lumbago, osteoarthritis, articular syndrome, rheumatic kab mob thiab gout exacerbation;
• psoriatic mob caj dab, arthralgia, ankylosing spondylitis;
• mob caj dab ntawm ntau yam keeb kwm, osteochondrosis nrog radicular syndrome;
• o ntawm ligaments, myalgia, rheumatic thiab rheumatoid keeb kwm, bursitis, o ntawm lub tendons;

• mob syndromes ntawm txawv keeb kwm (xws li kev poob plig, postoperative, hniav, algodismenoree, mob taub hau);
• inflammations ntawm lub licas thiab nqaij mos.

Nws yuav tsum tau muab sau tseg tias zoo rau "Nise" kub. Qhov no tshuaj yog siv nyob rau hauv ib tug kub cev ntawm txawv keeb kwm, nrog rau inflammatory thiab kis kab mob.

Contraindications narcotics yuav muab

Tshuaj "Nise" txwv tsis pub tsa cev xeeb tub. Tsis tas li ntawd, nws yuav tsum tsis txhob yuav siv tau:

• "Aspirin triad";
• erosive thiab ulcerative txhab ntawm tus mob huam (nyob rau hauv exacerbation);
• kev pub niam mis;
• los ntshav los ntawm tus mob huam;
• impaired siab muaj nuj nqi;
• nyob rau hauv cov me nyuam mus txog ob lub xyoos;
• mob loj heev raum insufficiency;
• giperuvstvitelnosti.

Nrog tshwj xeeb ceev faj no neeg sawv cev kws kho rau mob ntshav qab zib mellitus hom, tawg thiab mob insufficiency.

Yuav ua li cas tau "Nise"?

Saib cov tshuaj nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj tshuaj xwb hauv. Tus neeg laus cov neeg mob nws yog pom zoo kom noj 100 mg ib hnub ob zaug. Qhov siab tshaj plaws ntau npaum ntawm cov tshuaj ib hnub twg yog 400 mg.

Nrog kev xav txog dispersible ntsiav tshuaj, ces, ua ntej ua xws li ib tug tshuaj, nws yuav tsum tau yav tas yaj nyob rau hauv 5 ml ntawm zoo tib yam dej (1 dessert diav). Kom lub cuab tam yuav tsum nyob rau thaum xaus ntawm ib tug noj mov los yog tom qab ib tug noj mov.

Cov me nyuam tshuaj nyob rau hauv cov ntsiav tshuaj tsis muab rau koj. Rau lawv, muaj lwm daim ntawv ntawm cov tshuaj - qhov kev ncua. Nws yog pom zoo kom noj cov muaj hnub nyoog ob xyoos.

phenomena sab

Kev npaj "Naiz", ntau npaum ntawm uas hais saum toj no tej zaum yuav ua rau undesirable tshua xws li:

• kub siab, mob siab, xeev siab, anemia, ntuav;
• agranulocytosis, mob nyob rau hauv lub plab, anemia, raws plab, leukopenia;
• erosive thiab ulcerative txhab ntawm tus mob huam, mob taub hau, nce nyob rau hauv daim siab transaminases;
• anaphylactic poob siab, kiv taub hau, daim tawv nqaij ua pob liab vog;
• prolongation ntawm los ntshav lub sij hawm, bronchospasm, hematuria, kua tuav tseg.

tus neeg mob ntawm overdose

Yuav ua li cas cov tsos mob tshwm sim thaum tau txais ib tug loj tus naj npawb ntawm "Nise" ntsiav tshuaj? Cov tshuaj ntawm cov tshuaj yuav tsum tau txiav txim los ntawm lub mus kawm tus kws kho mob. Nyob rau hauv cov ntaub ntawv ntawm cov lo haus ntawm cov tshuaj (nyob rau hauv loj qhov ntau), tus neeg mob tej zaum yuav tsim lub nram qab no cov tsos mob: convulsions, nce ntshav siab, voos ntawm tus mob huam, impaired raum muaj nuj nqi, daim siab tsis ua hauj lwm, thiab ua pa nyuaj siab.

Yuav kom tshem tawm tej lub xeev ntxuav neeg mob plab, tshuab txais hluav ncaig thiab symptomatic txoj kev kho.

tshuaj cov kev sib tshuam

Nrog simultaneous preroralnom txais tos kev npaj "Naiz" diuretics "Digoxin" "phenytoin", antihypertensive neeg thiab lithium agents, raws li zoo li lwm yam NSAID, cyclosporine, anticoagulants, methotrexate, hypoglycemic tshuaj (qhov ncauj), tus neeg mob tej zaum yuav tshwm sim tshuaj cov kev sib tshuam (los ntawm -Qhov no cov agents lwv rau cov thwj toob nrog cov nqaijrog).

Tshuaj "Nise": analogs thiab xyuas

Hloov lub cuab tam yuav suav hais tias tej tshuaj raws li "nimulid", "raws li qhov", "Arcoxia", "Mesulid", "meloxicam", "Nimesil", "Movalis" "nimesulide" "Denebola", "Niemiec".

Feem ntau ntawm cov neeg xyuas rau tam sim no formulation zoo. Raws li lawv, nws yuav rhuav tshem sai sai "Nise" mob, cov tshuaj no kuj siv tau raws li ib tug heev zoo anti-inflammatory tus neeg saib xyuas. Txawm tias ib co neeg mob hais tias cov tshuaj no muaj ib tug loj drawback. Nws yog ib heev feem ntau ua rau sab tshua xws li kiv taub hau, tsis muaj zog thiab digestive system muaj teeb meem. Nyob rau hauv cov ntaub ntawv no, cov kws kho mob pom zoo kom hloov cov tshuaj uas zoo sib xws.