Cov tshuaj "Baraklyud": cov lus qhia rau kev siv, hauj lwm, muaj pes tsawg leeg thiab xyuas

"Baraklyud" yog hais txog anti-retroviral tshuaj, ib feem ntawm cov pab pawg neeg ntawm nucleoside analogues. Ntawv sau yuav tshuaj rau cov kev kho mob ntawm tus kab mob HBV-kab mob. Lub active ingredient ntawm cov tshuaj entecavir sai sai suppresses kis replication ntawm tus kab mob siab.

Nws yuav tsum tau yuav kawm annotation ua ntej yuav noj cov tshuaj. Raws li qhia los ntawm cov lus qhia rau kev siv? "Baraklyud" (Baraclud) - ib tug yeeb tshuaj uas yog npaj mus pib lub backflow ntawm fibrotic dab nyob rau hauv cov neeg mob uas lub siab mob npuas paug.

cov tshuaj

Cov tshuaj no muaj nyob rau ob ntau npaum xaiv - 0.5 thiab 1 mg entecavir active tivthaiv visually differing nyob rau hauv cov xim xim (dawb los yog liab, ntsig txog).

Cov kev npaj kuj muaj xws li:

• polysorbate;
• magnesium stearate;
• lactose monohydrate;
• Valium;
• povidone;
• colorant Opadry.

pharmacological los

Lub active ingredient yog entecavir uas yog ib tug analogue ntawm lub nucleoside guanosine, tau hais xim kev ua si mus tus kab mob siab B.

Entecavir yog phosphorylated rau ib tug active triphosphate nrog ib tug ib nrab-lub neej txog 15 cov sij hawm, cov intracellular cov ntsiab lus uas muaj feem xyuam rau lub concentration ntawm entecavir sab nraum hlwb. Thaum zoo li no yog tsis cai appreciable txuam nrog ntawm active tshuaj nyob rau hauv lub cev. Tshuaj "Baraklyud" cov lus qhia rau kev siv uas qhia nws cov high efficiency, suppresses cov kev ua ntawm tus kab mob polymerase, impacting ib txhij rau peb yam tseem ceeb:

• synthesis ntawm qhov zoo strand ntawm DNA HBV;
• rov qab transcription ntawm qhov tsis zoo xov pregenomic mRNA;
• HBV priming enzyme.

Triphosphate tsis yog ib tug muaj zog retarders enzymes cellular DNA, txawm nrog ib tug ntau yam pauv loj cov ntsiab lus ntawm tsis ntxim rau mitochondrial DNA synthesis.

nyhuv ntawm cov tshuaj

Lub active tshuaj yam khoom uas yuav muaj peev xwm sawv ntawm ib tug luv luv lub sij hawm yuav absorbed los ntawm lub digestive system thiab nce mus txog lub siab tshaj plaws ntawm nws txheem nyob rau hauv 30-90 feeb tom qab noj cov ntsiav tshuaj.

Commensurate nce nyob rau hauv Cmax thiab AUC indices tshwm sim nyob rau hauv tom ntej siv 0.1-1 mg ntawm medicament "Baraklyud". Cov lus qhia rau kev siv tham txog moog ib tshuav nyiaj li cas nyob rau hauv lub 6-10-th hnub ntawm ib koob tshuaj ntawm cov tshuaj ib hnub twg. Siv fatty khoom noj ho complicates entecavir haum txheej txheem, subtracting codes Cmax thiab AUC los ntawm 45% thiab 20% feem.

Lub tshuaj no yog sai absorbed nyob rau hauv cov ntaub so ntswg thiab los ntawm 13% bound rau ntshav proteins. Lub active tshuaj tivthaiv yog tsis muaj feem xyuam rau substrates, enzyme inhibitors los yog inducers ntawm P450 system. Nws yog tau noog nyob rau hauv lub cev thiab tso zis los ntawm lub raum system los ntawm glomerular filtration thiab tubular tawm.

indications

Medicament "Baraklyud" pom zoo kom coj nyob rau hauv txoj kev kho mob ntawm tus kab mob siab B:

• Nrog tam sim no cov tsos mob ntawm tus kab mob replication thiab nce ntawm cov neeg kawm ntawv ntawm kev ua si ntawm transaminases nyob rau hauv lub ntshiab, nyob rau hauv lub xub ntiag ntawm histological ces mus tsis tu ncua o ntawm lub siab.
• Unrecovered siab txhab.

Tseem ceeb nyem ntawm daim siab tus kab mob cov tsos mob tshwm sim tom qab cov tshuaj thawj coj "Baraklyud". Ntsiav tshuaj phau ntawv qhia xav kom cov neeg mob uas mob tus kab mob siab B, daim siab tus kab mob nyuab los ntawm cov nram qab no:

• nyob decompensated;
• pathological siab mob nyob rau hauv ib tug raug mob kauj ruam thaum ntsia tus kab mob replication thiaj paub hais tias kev muaj siab fibrosis nrog nce AST thiab ALT.

Contraindications

Cov tshuaj "Baraklyud" muaj cov nram qab no contraindications:

• nce nyhav rau entecavir thiab lwm yam muaj nyob rau hauv cov tshuaj muaj pes tsawg leeg;
• raws roj ntsha lactose intolerance, qabzib-galactose malabsorption, tsis muaj peev xwm los yog tsis tuaj kawm ntawv nyob rau hauv lub cev ntawm lub enzyme lactase ;
• muaj hnub nyoog tsawg tshaj 18 xyoo.

Cov neeg uas muaj mob raum tsis ua hauj lwm yuav tsum tau cov tshuaj nyob rau hauv cov tshuaj thiab nyob rau hauv qhov kev kho mob saib xyuas.

Txais tos "Baraklyuda" thaum lub sij hawm cev xeeb tub yog tsis pom zoo thaum lub sij hawm txoj kev kho xav tau kom tsis txhob pub niam mis.

phiv

Tej zaum yuav muaj ib tug ntau yam ntawm mob ntawm lub digestive system thaum lub sij hawm txoj kev siv tshuaj "Baraklyud". Cov lus qhia rau kev siv yog kom meej meej piav sab los:

• digestive mob;
• raws plab;
• xeev siab thiab ntuav;
• dyspepsia.

Tej zaum koj kuj muaj kev mob taub hau, insomnia los yog koj nkees nkees, tsis qab los noj mov, thiab kev tsis haum tshuaj loj.

Thov tshuaj raws li ib tug tib tug kho tus neeg saib xyuas los yog nyob rau hauv ua ke nrog nrog rau lwm cov antiretroviral tshuaj yuav ua rau mob loj heev hepatomegaly nrog steatosis, uas tej zaum yuav ua rau tus neeg mob tuag.

Nyob rau hauv cov neeg mob uas decompensated saib laktatsiadoz txhab zaum yuav tshwm sim lub siab, uas yog yus muaj los ntawm:

• general leeg tsis muaj zog;
• ceev ceev ua tsis taus pa thiab cov tsos ntawm ua tsis taus pa;
• xeev siab;
• tseem ceeb yuav txo tau ntawm lub cev hnyav;
• mob nyob rau hauv lub peritoneum, epigastric.

Tsis tas li ntawd, cov tshuaj yuav ua rau sib txawv tshua thiab lub cev:

• nce nqi ntawm hepatic transaminases;
• daim tawv nqaij sawv pob;
• anaphylactoid cov tshuaj tiv thaiv.

Cov neeg mob tseem raug kev txom nyem decompensated daim siab mob, nyob rau hauv tas li ntawd, xws tshua yog manifested kab mob:

• raum tsis ua hauj lwm (nyob rau hauv uas tsis tshua muaj neeg mob);
• nce bilirubin cov ntsiab lus nyob rau hauv cov ntshav;
• . Txos ntawm lub platelet suav rau 50 txhiab / hli ³ los yog tsawg dua;
• yuav txo tau ntawm bicarbonate nyob rau hauv cov ntshav;
• nce ntawm ALT;
• ntau tshaj peb-fold nce nyob rau hauv cov kev ua ntawm lipase;
• txo theem ntawm albumin.

Medicament "Baraklyud": ntau npaum thiab tswj

Cov tshuaj yuav tsum tau noj nyob rau hauv ib qho kev npliag plab, lub sij hawm lub sij hawm ntawm lub xeem noj mov ua ntej dosing yuav tsum tau ntau tshaj li ob teev.

Thaum compensated rau lub siab puas pom zoo txais tos "Baraklyuda" 0.5 mg txhua txhua hnub. Nyob rau hauv paub kuj mus lamivudine ntau npaum yuav tsum tau ob npaug.

Cov neeg mob uas siab txhab unrepaired tshuaj txhua txhua hnub kom tsawg ntawm 1 mg. Rau cov neeg laus thiab cov neeg mob raum insufficiency, cov tshuaj yuav tsum tau tom nyob ntawm seb nyob rau theem ntawm CK (creatinine concentration) nyob rau hauv cov ntshav.

overdose

Cov ntaub ntawv nyob rau hauv tus neeg mob ntawm tshuaj overdose yog tsis txaus.

Ua haujlwm pab dawb, uas yog clinically kuaj, tau txais ib tug txhua txhua hnub ntau npaum ntawm 20 mg rau ob lub lis piam lawv tau muab ib zaug xwb ntau dua koob tshuaj - 40 mg tshuaj "Baraklyud". Cov lus qhia rau Siv hais tias tsis zoo los raug kuaj.

Pom zoo posindromnoe kev kho mob nyob rau hauv lub saib xyuas ntawm kev soj ntsuam ces.

Sis nrog lwm yam tshuaj

Vim lub fact tias cov active tivthaiv entecavir yog tas feem ntau los ntawm lub raum system, complex kho nyob rau hauv ua ke nrog nrog lwm yam tshuaj uas muab ncaj qha los yog xu los ntawm cov raum muaj nuj nqi thiab muaj feem xyuam rau tubular secretion, tej zaum yuav raug nyob rau hauv ib qho kev nce rau hauv lub cev ntawm entecavir thiab lub active tshuaj ntawm tshuaj.

Sis "Baraklyuda" nrog adenovirom, tenofovir, lamivudine twb tsis kaw.

precautionary ntsuas

Txais ntawm cov tshuaj cov neeg mob resistant rau lamivudine ua rau txoj kev pheej hmoo ntawm kev tsim kuj.

Tsis tas li ntawd, muaj pov thawj ntawm qhov tshwm sim ntawm exacerbations ntawm tus kab mob siab B tom qab discontinuation ntawm cov tshuaj "Baraklyud". Cov lus qhia rau kev siv qhia txog cov nyem ntawm exacerbations tsis ntxiv txoj kev kho.

ceev faj

Txais tos "Baraklyuda" nyob rau hauv lub moj khaum ntawm monotherapy thiab ua ke kev kho mob nrog rau lwm cov antiretroviral cov neeg ua hauj, yuav ua tau lactic acidosis, hepatomegaly nrog steatosis. Nyob rau hauv cov ntaub ntawv no, muaj ib tug raug tuag.

Thaum yuav raug cov neeg mob muaj xws li cov nram no:

• kev txom nyem los ntawm hepatomegaly;
• yuav tsum tau kho nrog rau cov kev siv ntawm nucleoside analogues;
• muaj nyhav dhau heev lawm;
• poj niam cov neeg mob.

Cov lus qhia rau kev siv ntawm cov tshuaj "Baraklyud" sau ntawv tau tsim los ntawm cov resistant kab lim. Active muaj entecavir tshuaj no yog tsis pom zoo rau cov kev kho mob ntawm human immunodeficiency virus vim hais tias ntawm nws cov efficiency rau hauv no coj tsis tau kawm nyob rau hauv tag nrho.

Nyob rau hauv cov kev kho mob ntawm cov neeg mob nrog pathology ntawm lub raum system, yog tsim nyog los kho cov tshuaj.

Txoj kev nyab xeeb thiab cov hauj lwm zoo ntawm kev siv "Baraklyuda" rau cov kev kho mob ntawm cov neeg mob tom qab lub siab hloov tsis tau paub thiab yuav tsum tau kev pab tshwj xeeb raws li kev ntsuas.

Cia tej yam kev mob thiab nqi

Cia thiab kev thauj mus los ntawm pellets yuav tsum tau nqa tawm nyob rau hauv lub kub ntau 15-25 ° C. Cov kev npaj yog haum rau siv rau ob xyoo ntawm hnub uas siv thiab ua.

Cov tshuaj no yog muaj nyob rau hauv ib tug nyias muaj nyias ib pab pawg neeg ntawm tseem ceeb cov tshuaj, thiab vim hais tias tej yam pawg ntawm cov pej xeem muab tus me nyuam dawb ntawm cov tshuaj "Baraklyud". Cov lus qhia rau kev siv captures no qhov tseeb.

Nqe txhais tau tias nyob rau hauv Moscow chaw muag tshuaj yog pib los ntawm 12 txhiab. Rubles.

Views ntawm cov neeg mob

Nws qhia lub siab miv nyuas siv zug ntawm cov tshuaj "Baraklyud" phau ntawv qhia. Nqe, xyuas ntawm uas pom hais tias nws yog kev ywj pheej nyob rau hauv kev sib piv nrog analogues ntawm cov tshuaj, mas nws txawv ntawm 12-17 txhiab ib pob, nyob rau hauv uas 30 pellets. Qhov no ua rau cov tshuaj ib tug heev nrov thiab nyob hauv kev thov ntawm cov neeg mob rau cov kev kho mob ntawm tus kab mob siab B.

Nyob rau hauv qhov tsis zoo tswv yim mas xa proitvopokazaniya thiab tshwm sim los ntawm cov tshuaj, xws li insomnia, thiab xeev siab.