"Clarotadine": cov lus qhia rau siv. Qhov twg yuav kom tau Clarotadine? Los ntawm dab cov ntsiav tshuaj "Clarotadine"? Analogues ntawm "Clarotadine"

Cov kev tsis haum tshuaj - yog lub ntsiab lus tseem ceeb, tshwj xeeb yog rau cov niam txiv. Tom qab tag nrho, txhua xyoo tus xov tooj ntawm thiaj li hu ua "fab" yog qhov nce ntxiv. Yog li hnub no peb yuav xav txog kev nthuav dav cov tshuaj "Clarotadine". Cov lus qhia rau kev siv yuav pib peb kev soj ntsuam ntawm cov tshuaj no. Peb xav kom koj nyeem nws ua ntej siv nws. Koj tuaj yeem yuav tau cov tshuaj Clarotadine hauv koj lub tsev muag tshuaj hauv koj lub nroog thiab tsis muaj ntawv sau tshuaj.

Thaum twg thiaj li tau thov

Lub medicament tej zaum yuav siv nyob rau hauv kev tsis haum conjunctivitis, angioedema, nrog urticaria (mob mob thiab idiopathic). Cov tshuaj "Clarotadine" kuj tseem siv tau rau lub caij nyoog ib xyoos puag ncig lossis caij rhinitis; Cov kab mob pseudoallergic, uas yog tshwm sim los ntawm kev tso cov kab mob histamine; Kev sib cav rau cov tom ntawm ntau yam kab; raws li zoo raws li khaus dermatoses. Daim ntawv teev npe yuav tau ntxiv.

Dab tsi yog tsim tawm

Xav txog thawj lub tshuaj "Clarotadine" -syrup. Cov lus qhia siv nws yuav raug muab rau hauv qab no. Txiav - 5 mg / 5 ml. Loratodina (active ingredient) yog milligram ib milliliter ntawm syrup. Cam: propylene glycol, qab zib, benzoic acid, ethyl cawv, citric acid, tropeolin, purified dej, khoom noj khoom haus flavorings.

Nws tau tso rau hauv lub raj mis uas tsaus nti, uas nws muaj peev xwm yog ib puas milliliters. No lub vial yog nyob rau hauv ib lub thawv ntawv. Cov khoom siv kuj muaj qhov ntsuas tshwj xeeb ntsuas.

Tam sim no xav txog cov ntsiav tshuaj "Clarotadine". Ib ntsiav tshuaj muaj kaum milligram ntawm loratodine. Ntawm cov koom haum pab pawg - MCC, cov mis nyuj qab zib, calcium stearate, glycolate, sodium starch. Lawv muab tso rau hauv contour squares, txhua nrog xya lossis kaum pieces. Nyob rau hauv cov thawv ntawv muaj peev xwm ua tau los ntawm ib mus rau peb pob ntawv-daim hlau.

Pharmacodynamics

Cov tshuaj no yog rau H1-antihistamine cov tshuaj, uas tsis muaj anticholinergic thiab central action. Pib ua haujlwm tom qab siv ib nrab tom qab siv thiab siv tau 24 xuab moos. Nws yog ib qho tseem ceeb uas siv cov tshuaj no ntev heev tsis thev taus rau nws. Nws yuav tsum tau sau tseg tias cov khoom loratodine, thiab nws cov metabolites tsis tuaj yeem nkag mus rau BBB.

Pharmacokinetics

Thaum hais txog kev nqus, thaum noj tshuaj hauv cov tshuaj uas tau pom zoo los ntawm cov khw, qhov tseem ceeb ntawm loratodine yog ceev nrooj thiab tag nrho nqus hauv lub hauv nruab nrab ntawm txoj hnyuv. Lub concentration ntawm uas muaj peev xwm twb txiav txim, tshwm sim nyob rau hauv nyob tus yeees ntawm cov ntshav ntshav kaum tsib feeb tom qab noj mov. Raws li lub sij hawm mus cuag Cmax hauv loratodine plasma, nws yog qhov ntev ntawm ib teev plaub caug feeb mus rau ob xuab moos peb caug feeb.

Tab sis lub sij hawm ua tiav Cmax ntawm nws lub cev metabolite yog ze peb teev. Tsuas nco ntsoov tias tib lub sij hawm noj cov zaub mov nrog rau cov tshuaj yuav ua rau kev ua tiav ntawm Cmax loratodina, thiab nws cov metabolite hauv plasma li ib teev. Tib lub sij hawm, Cmax ntawm cov tshuaj no yuav tsis hloov, thiab cov zaub mov tsis muaj peev xwm cuam tshuam cov txiaj ntsim ntawm txhua txoj kev.

Tam sim no hais txog cov neeg laus. "Clarotadine" (cov lus qhia rau kev siv cov ntawv sau), lawv tuaj yeem nqa tsis tau tshwj xeeb txog cov hnub nyoog. Cia li nco ntsoov tias lub sij hawm kom ncav cuag Cmax nce li ib teev thiab ib nrab, tsis zoo li cov tub ntxhais hluas. Li rau daim siab mob siab, nyob ntawm seb qhov mob loj npaum li cas, lub sijhawm kom ncav cuag Cmax kuj nce siab.

Hauv cov ntshav ntshav, cov ntsiab lus ntawm loratodine nrog nws cov metabolite tuaj txog ntawm cov neeg mob feem ntau nyob rau hauv cov neeg mob feem ntau ntawm tsib hnub tom qab kev tswj xyuas. Thiab txoj kev txuas nrog cov ntshav proteins yog 97%.

Metabolism

Nyob rau hauv daim siab, cov khoom ua ke loratodin metabolized, sib sau ua ib qho metabolite ntawm descarbotoxyloratadine. Qhov no yog vim qhov kev txiav txim ntawm cytochrome P450 isoenzyme CYP3A4. Cov nyhuv ntawm cov cytochrome P450 isoenzyme CYP2D6 kuj muaj cov nyhuv, tab sis kom tsawg zog. Tam sim no cectonazole, uas yog ib qho inhibitor ntawm CYP3A4, pub rau loratodine kom hloov dua siab tshiab rau descarbotoxyloratadine. Qhov no yog vim muaj teebmeem ntawm CYP2D6.

Tshaj tawm

Qhov kev npaj "Klarotadin" (cov lus qhia hauv daim ntawv tseem hais txog nws lossis qhov no hais txog) los ntawm lub raum, thiab kuj tau nrog rau lub kaspivtaw. Qhov nruab nrab T1 / 2 ntawm loratadine yog yim teev thiab nees nkaum feeb (qhov ntau yuav yog li ntawm peb mus rau nees nkaum teev). Raws li rau lub cev metabolite, nws qhov nruab nrab muaj hnub nyoog nees nkaum yim (qhov ntau yuav yog los ntawm 6 teev plaub caug feeb mus rau peb caug xuab moos).

Tus nqi nruab nrab ntawm descaboethoxyloratadine yog kaum xya moos thiab peb caug feeb (ntau ntawm kaum rau mus rau peb caug-yim teev). Yog hais tias nws yog ib qho teeb meem ntawm kev puas siab puas ntsoog los ntawm kev haus dej caw, ces T1 / 2 yuav nce ntxiv nrog rau kev loj hlob ntawm tus kab mob. Tab sis nyob rau hauv cov neeg mob uas muaj mob plawv tsis zoo, thiab kuj yog leej twg hauv lub cev hemodialysis, cov tshuaj pharmacokinetics tsis hloov ntau ntau.

Cev xeeb tub

Cov pojniam xeebtub yuav tsum tsis txhob siv cov tshuaj no, vim "Clarotadine" rau cov menyuam yaus uas nyob hauv plab menyuam, yuav tsim teebmeem. Yog tias qhov kev xav tau los ntawm kev siv cov tshuaj no los ntawm leej niam leej txiv, ces nws yuav tsum tau mus noj niam mis kom txog thaum kho tiav.

Contraindications

Zoo ib yam li lwm yam tshuaj, muaj kev tsis sib haum xeeb thiab "Clarotadine". Cov lus qhia rau kev siv qhia tau tias cov tshuaj no tsis tuaj yeem siv yog tias tus neeg mob tau mob siab rau ib qho ntawm cov tshuaj no. Cev xeeb tub thiab lactation yog ib qho tseem ceeb ntawm qhov kev kho mob no tsis tau sau tseg thiab tsis txais. Cov neeg mob uas muaj kev puas siab puas ntsws yuav tsum noj tshuaj Clarotadine nrog ceev faj.

Tej Teebmeem

Tam sim no peb yuav tsum tham txog seb qhov tshuaj no ua rau tib neeg lub cev. Kev puas tsuaj ntawm tus kab mob hauv lub cev yog qhov ua tau, xws li ntxhov siab, mob qaum asthenia, hyperkinesia, ntxhov siab hauv tus me nyuam, kev txhoj nkees, tshee, muaj kev nyuaj siab, kev nyuaj siab thiab kev puas siab ntsws. Subcutaneous rog, raws li tau zoo raws li daim tawv nqaij muaj peev xwm tshwm sim rau lub cheebtsam ntawm cov tshuaj nrog dermatitis.

Yog tias peb tham txog tus kab mob genitourinary, ces nws tuaj yeem hloov xim ntawm cov zis, tus neeg mob yuav xav kom tso zis, uas yuav muaj mob. Kev mob vaginitis, dysmenorrhea thiab menorrhagia tuaj yeem tsim tau.

Los ntawm txoj kev kaw lus endocrine kuj tseem ua txhaum. Qhov hnyav tuaj yeem nce, tus neeg mob yuav tau nqhis dej, thiab nws kuj tau tawm hws. Cov kab mob musculoskeletal kuj tuaj yeem siv qee qhov kev tsis sib haum hauv nws txoj haujlwm. Qhov no yog lub spasm ntawm calf cov leeg, thiab myalgia, thiab arthralgia.

Lub plab tseem tuaj yeem tsim txom. Distortion ntawm saj, raws plab lossis cem quav, anorexia, gastritis, dyspepsia, muaj zog nqus, flatulence thiab stomatitis - tag nrho cov no nrog qee qhov muaj tseeb yuav tshwm sim thaum siv Clarotadine.

Cov kab mob ntsws kuj raug cuam tshuam. Kev quab yuam yuav tshwm nyob rau hauv daim ntawv ntawm ib lub bronchospasm, ib qho hnoos, ib qho hlwv dej, thiab ua rau lub plab hnyuv ntawm lub qhov ntswg. Tsis tas li ntawd, tus kab mob conjunctivitis yuav tsim tau, qhov muag pom tsis tau, mob hauv pob ntseg thiab qhov muag yuav tshwm sim. Cov kab mob plawv kuj raug rau cov kev mob tshwm sim, uas tuaj yeem tshwm sim rau hauv daim ntawv ntawm lub plawv dhia ceev ceev, ntshav nce siab, thiab nws txoj kev txo qis.

Muaj ntau zaus muaj kev tsis haum tshuaj, tshwm sim nyob rau hauv daim ntawv ntawm angioedema, khaus khaus, khaus khaus thiab cov tshuaj pleev xim. Tej zaum kuj yuav muaj mob rov qab, kub cev, mob mob lub siab, mob hauv siab, ua daus no, ua mob hnyuv, thiab mob hauv cov qog qog.

Raws li koj tau pom, cov kev mob tshwm sim tuaj yeem ua rau muaj mob loj heev, yog li tsis nco qab txog nws. Kev sab laj ntawm ib tus kws kho mob yog yuav tsum ua ob qho tib si ua ntej thawj zaug txais ntawm yeeb tshuaj, thiab thaum nrhiav tau cov teeb meem saum toj no.

Daim ntawv thov thiab tshuaj noj

Syrup thiab ntsiav tshuaj "Clarotadine" los ntawm qhov uas - xam tawm. Tam sim no cia peb tham txog yuav ua li cas. Cov tshuaj no yog siv rau kev siv sab hauv. Cov me nyuam yaus uas muaj hnub nyoog tshaj kaum ob xyoos, nrog rau cov laus, txhua hnub txhaj tshuaj yog 10 milligram. Cov no yog ob qho txiaj ntsig ntawm kua phev los yog ib lub tshuaj. Tab sis rau cov menyuam yaus txij li ob mus rau kaum ob xyoos, nws lub cev hnyav tsawg tshaj peb caug kilograms, nws raug nquahu kom siv tsib milligrams. Qhov no yog ib qho ntsuas diav lossis ib nrab ib ntsiav tshuaj. Cov koob tshuaj txhua hnub yuav tsum tsis pub dhau daim duab no. Yog hais tias qhov loj yog ntau tshaj peb caug kilograms, qhov ntau npaum li cas yuav zoo ib yam li cov laus.

Overdose

Yog tias koj tsis mloog cov lus pom zoo thiab siv cov tshuaj hauv ntau qhov ntau, koj tuaj yeem pom cov tsos mob ntawm cov laus, uas tam sim no yuav tau muab teev tseg. Qhov no yog tachycardia, mob taub hau thiab kev tsaug zog. Thiab hauv cov menyuam yaus, nws lub cev hnyav tshaj li peb caug kilograms, nrog rau kev noj tshuaj ntau dua, nws muaj qee lub plawv dhia, thiab cov tsos mob ntawm extrapyramidal.

Yog tias tus neeg mob tau txais qeeb dua, koj yuav tsum hu rau tus kws kho mob tam sim ntawd. Nws tseem yog ib qho tseem ceeb uas yuav tsum tau ntsuas kom paub tseeb tias cov tshuaj tau raug tshem tawm ntawm txoj hnyuv tawm thiab txoj hnyuv tau txo. Qhov no yog ua los ntawm inducing ntuav, ntxuav lub plab, thiab siv cov activated carbon. Yog tias tseem ceeb, kev kho kab mob symptomatic yuav tsum tau ua. Nws yuav tsum nco ntsoov tias cov khoom tsis zoo ntawm loratadine tsis tau tawm ntawm lub cev los ntawm hemodialysis. Tsis tas li ntawd, yog tsis muaj cov ntaub ntawv nyob rau hauv feem ntawm no lub caij thaum lub sij hawm peritoneal lim ntshav.

Kev sib tham nrog lwm cov tshuaj

Yog tias koj ua ntawv thov Clarotadine hauv ib qho tshuaj kho mob, tsis pom muaj teeb meem nrog cov dej cawv. Thiab thaum siv cov tshuaj no nrog tshuaj tua kab mob "Cimetidine", "Erythromycin" thiab "Ketoconazole", cov concentration hauv ntshav ntshav ntawm loratodin yuav nce. Qhov tshwm sim no tsis yog clinically pom tseeb, thiab tseem tsis ntxim rau lub electrocardiogram.

Muaj pov thawj hais tias tus inductors ntawm microsomal oxidation, uas muaj xws li ethanol, phenytoin, barbiturates, rifampicin, ziksorin, tricyclic antidepressants, phenylbutazone, yuav txo tau cov hauj lwm zoo ntawm cov tshuaj no.

Cov lus qhia tshwj xeeb

Cov neeg mob uas muaj kev puas siab ntsws los ntawm kev ua haujlwm tsis zoo thiab cov uas tsis ua hauj lwm (glomerular pom muaj tsawg tshaj peb caug mL / min) qhov kev pom zoo thawj zaug ntawm Clarotadine yuav tsum tsis pub tshaj 10 milligrams (ib ntsiav tshuaj los yog ob lub ntsuas phoov) Hnub. Koj tsis tuaj yeem muab cov tshuaj no rau cov menyuam yaus uas muaj hnub nyoog tsawg dua ob xyoos.

Txhua tus neeg uas pib noj cov tshuaj no yuav tsum tsis kam lees txhua lub sij hawm ntawm kev kho mob ntawm kev ua hauj lwm txhua yam ntawm cov dej num uas yuav phom sij uas yuav tsum tau muaj kev mloog ntau ntxiv, thiab qhov ceev ntawm kev xav ntawm kev xav ntawm lub hlwb.

Analogues

Nws yuav ncaj ncees hais tias cov tshuaj "Clarotadine" tsis yog tib qho ntawm nws hom. Muaj cov analogues ob qho tib si ntawm cov khoom noj txom ncauj domestic thiab cov tshuaj. Ib qho txawv teb chaws "colleague" yog cov tshuaj "Claritin". Nws cov khoom yog yuav luag tib yam li nyob rau saum toj-hais tshuaj "Clarotadine". Nqe yog qhov txawv txav. Tshuaj txawv teb chaws yog kim dua. Domestic muaj nqi, nyob ntawm cov khoom siv. Yog li, lub pob ntawm 7 pcs. Yuav raug nqi li 100 rubles., Ntawm lub xov tooj ntawm tes 10 x 3 - txog 270 rubles thiab syrup 100 ml - txog 135 rubles.

Peb yuav tsis sib tham ntawm no ntawm nqe lus uas nws yog qhov zoo uas yuav siv - Clarotadine los yog Claritin. Qhov no yog ib qho teeb meem ntawm txhua tus neeg, thiab koj yuav tsum txiav txim siab rau koj tus kheej, yuav ib qho tshuaj pheej yig uas pheej yig, los yog muab qhov tseem ceeb tshaj rau lwm tus neeg txawv teb chaws. Tab sis nws yog tsim nyog sau cia tias rau tag nrho cov xyoo, cov tshuaj "Clarotadine" ua pov thawj zoo heev. Analogs nyob rau hauv cov ntaub ntawv no tshwm txhua hnub.

Nyob rau hauv txhua rooj plaub, ua ntej koj pib noj cov tshuaj no thiab tag nrho cov ntau tshaj tawm lawv rau cov me nyuam, nco ntsoov nrog koj tus kws kho mob. Qhov no yuav tiv thaiv koj ntawm qhov tsis zoo uas tsim nyog los ntawm kev tsis txaus siab ntawm cov tshuaj, nws siv tsis dhau los yog tshaj saud. Nws yuav tsum nco ntsoov tias qhov zoo li no yuav tsim teeb meem rau koj kev noj qab haus huv, kev noj qab nyob zoo ntawm koj cov me nyuam, thiab koj lub neej.