Calcium citrate: yam ntxwv, mechanism ntawm qhov kev txiav txim, kev siv cov

Lub ib thooj ntawm Ca nyob rau hauv ib tug neeg laus lub cev (txog 99%) muaj nyob rau hauv cov pob txha cov ntaub so ntswg uas muaj hydroxyapatite muaju. Nyob rau hauv cov ntshiab feem ntau hom tsiaj, calcium concentration yog hais txog 3 mmol / l (10-12 mg / 100 ml) thiab yog qhov. Txhua hnub hloov mus hloov los ntawm lub constants tsis pub tshaj 3-5%. Ca yog qhov tseem ceeb rau tej hauj lwm ntawm lub paj hlwb. Lub neuromuscular synapses calcium ions txhawb kev tso tawm ntawm acetylcholine thiab choline compound nrog nws receptor, thiab thaum tshuab txais los ntawm acetylcholine tshaj cholinesterase - ib qho enzyme uas hydrolyzes acetylcholine.

Ca ions yog muaj nyob rau hauv lub sarcoplasmic reticulum, txhawb kev sis raug zoo ntawm actin thiab myosin, i.e. yuav txo tau ntawm nqaij fibers. Cov nyhuv no yog nqa tawm nyob rau hauv lub xub ntiag ntawm magnesium ions.

Calcium ions qhib lub enzymatic dab nyob rau hauv thawj zaug rau theem ntawm cov ntshav txhaws - nyob rau hauv lub tsim ntawm thrombin thiab thromboplastin. Cov thwj toob ntawm calcium ions nyob rau hauv cov ntshav oxalate los yog citrate tiv thaiv cov ntshav txhaws.

Tsis ntev los no muaj pov thawj cim luag hauj lwm ntawm calcium nyob rau hauv cell kev ua si, nyob rau hauv uas lub cytoplasm, nws concentration tsis pub tshaj 10-6 tias. Thaum lub cellular theem, muaj rau yooj yim physiological dab uas yog nyob rau hauv lub concentration ntawm calcium ions:

a) lub cev muaj zog ua si ntawm hlwb (nqaij contraction);

b) cov excitability ntawm hlwb uas yog peev xwm los tsim electrostatic txiav txim tej zaum (nqaij laus, paj impulse photoreception mob contraction);

c) recovering tshuaj uas yog tsim nyob rau hauv lub cell (secretion ntawm cov tshuaj hormones thiab neurotransmitters);

g) lub xam nrog ntawm soluble tshuaj nyob rau hauv lub cell los ntawm vesiculation (phagocytosis);

d) ib intracellular metabolism (synthesis qabzib, lipolysis, thiab lwm yam);

e) ntawm tes tu tub tu kiv (mitosis thiab oocytes fertilization, phev kom).

Ca ions ua ke nrog kev nqaijrog muab elasticity thiab hardness ntawm cov pob txha. Niaj hnub nimno cov tshuaj siv ntau npaj muaj ions ntawm calcium (glyukanat, citrate, chloride, lactate, carbonate, phosphate, etc.). Calcium citrate yog ntawm kev tseem ceeb. Lub ntsiab theem ntawm calcium tso tawm los ntawm nws cov ceg (phosphates, sulfates, chlorides) nrog rau cov organic thiab pob zeb hauv av Cheebtsam ntawm cov zaub mov no tshwm sim nyob rau hauv lub plab nyob rau hauv tus ntawm acid chloride thiab proteolytic enzymes. Carbonic acid thiab phosphoric acid calcium ntsev nyob rau hauv acidic nruab nrab ntawm lub plab yog dissociated, thiab cov calcium nyob rau hauv ionized daim ntawv los yog nyob rau hauv txoj nrog soluble chelates nkag mus rau hauv me me hnyuv. Yog li ntawd, nyob rau hauv ib tug txo secretory kev ua ntawm lub plab muaj Ca suction yog tsis txaus, nws yuav ua tau ib yam ntawm cov yog vim li cas rau lub tshaj ntawm no nyob rau hauv lub cev. Calcium citrate yog zoo tshaj plaws yaj nyob rau hauv lub acidic ib puag ncig ntawm lub plab. Ionized calcium nkag penetrates lom week, txawm los ntawm lub tsho me nyuam teeb meem. Qhov loj ib feem (txog 80%) ntawm cov calcium tas nyob rau hauv cov quav, zis tso zis txog 20%. Vim hais tias calcium citrate es citrate ntsev txhawb yuav txo tau ntawm oxalate nyob rau hauv cov zis, cov kev siv ntawm cov tshuaj tsis ua rau tus tsim ntawm raum pob zeb.

Nws yog pom tias thaum lub sij hawm hmo ntuj tshuab txais xaiv ntawm mineral ntsev ntawm lub cev. Vim hais tias cov kws kho mob pom zoo kom koj noj calcium citrate nyob rau hauv lub yav tav su los yog ib hmo. Muaj pov thawj negative correlative piv ntawm cov koob tshuaj calcium npaj thiab kws ua si. Ua li cas nws txhais li cas? calcium citrate yog zoo dua absorbed los ntawm lub cev nyob rau hauv me me koob tshuaj. Yog li ntawd nws yog zoo tshaj plaws nqa mus siv rau cov tshuaj ob peb zaug ib hnub twg. Rau txhua lub hnub nyoog pab pawg neeg tsim physiological calcium noj kev cai. Calcium tshuaj raws li ib tug tiv thaiv thiab kho (rickets, txha, osteomalacia, rau strengthening kho hniav txha hniav laus) lub hom phiaj. Poov tshuaj citrate yog kws kho rau lub plawv tsis ua hauj lwm, kub siab, normalization ntawm lub acid-puag thiab dej-ntsev tshuav nyiaj li cas nyob rau hauv lub cev.