Bisphosphonates - yog dab tsi? Bisphosphonates rau txha

Licas ua ib tug ntawm lub ntsiab zog nyob rau hauv tib neeg lub cev. Hais tias nws yog ib tug them nyiaj yug rau tag nrho cov lub cev. Pob Txha noj qab haus huv yog ib qho tseem ceeb heev luag hauj lwm. Thaum muaj teeb meem nyob rau hauv cov pob qij txha, txha nqaj qaum, heev pob txha lov tshwm sim, tus neeg muaj lub neej zoo yog significantly txo. Ib tug xws li tus kab mob uas yog feem ntau nrog los ntawm xws li cov tsos mob yog kab mob.

Yog hais tias nyob rau hauv lub sij hawm mus ntsib ib tug kws kho mob, nws yog ua tau rau ho txhim kho tus neeg mob tus mob. Tam sim no, bisphosphonates siv los kho kab mob. Cov tshuaj yuav muab kev cia siab ntawm ib tug kho. Cia peb kawm saib zoo li cas ntawm cov tshuaj.

Yuav ua li cas yog bisphosphonates

Nws lub npe, qhov no pab pawg neeg ntawm cov tshuaj tau txais vim hais tias ntawm cov ntsiab lus nyob rau hauv cov qauv ntawm ob phosphonates. Lub mechanism ntawm qhov kev txiav txim yog zoo vim hais tias ntawm lub loj loj zoo sib xws nrog pirofosfonatami uas muaj ib tug loj feem nyob rau hauv cov kev cai ntawm cov calcium uas nyob rau hauv cov ntsiab lus hauv cov pob txha.

Nrog ib tug zoo xws li cov qauv, bisphosphonates inhibit enzymes uas yuav tsum tau muab pov tseg ntawm pirofosfonaty. Lawv zoo li khi calcium ions thiab kos lawv rov qab mus rau tus pob txha.

Qhov zoo sab ntawm lub txais tos ntawm cov tshuaj no yog hais tias cov tshuaj uas muaj bisphosphonates, tsuas muaj ib tug xim ntxim rau cov skeletal system, qhov twg tsub zuj zuj ntawm calcium.

Vim hais tias ntawm qhov kev txiav txim nyob rau hauv cov kev kho mob ntawm kab mob hauv nws yog ua tau los mus tiv thaiv txoj kev poob ntawm calcium thiab phosphorus, uas muaj ib tug zoo ntxim rau cov kev kho mob.

ntawm ntau yam bisphosphonates

Muaj ntau yam tseem tsis tau paub txog bisphosphonates. Yuav ua li cas yog nws? Nws yog tam sim no tsim peb tiam ntawm no pab pawg neeg ntawm cov tshuaj. Cov kws kho mob siv cov tshuaj, thiab cov thawj ob tiam. Tam sim no muaj ntau yam tshuaj inherently muaj bisphosphonates, tag nrho cov ntawm lawv muaj peev xwm yuav muab faib ua ob yam loj xws li:

1. Tej yam yooj yim tsis muaj nitrogen.
2. Cov pab pawg neeg ntawm bisphosphonates, uas muaj xws li nitrogen - aminobisphosphonates.
   

Qhov txawv ntawm ob pab neeg dag nyob rau hauv lub fact tias lawv muaj sib txawv los rau osteoclasts.

Nitrogen-muaj bisphosphonates

Yuav ua li cas yog nws? Cov nyiaj no nyob rau hauv nws muaj pes tsawg leeg muaj cov nram qab no cov khoom xyaw:

1. Ibandronatovaya acid belongs rau lub thib peb tiam, tsim tsis ntev los no tau muab siv heev ntse rau kev tiv thaiv ntawm txha nyob rau hauv cov poj niam, tshwj xeeb yog menopausal.
2. Zolendronovaya acid xyua ua rau tus pob txha ntaub so ntswg, muaj ib tug qhia tau anti-mob nyhuv. Nyob rau lub hauv paus ntawm no substance ua tshuaj xws li "Zometa", "Zolendronat".
3. Alendronate sodium correctors koom uas tsis yog-hormonal metabolism hauv cov pob txha ntaub so ntswg, yeej txhawb kom tsim ntawm tus pob txha qauv.
4. Ibandronate sodium uas tsim "Bonviva", "Boniva", "Bondronat" cheeb osteoclast kev ua si, tab sis tsis muaj kev cuam tshuam lawv tus xov tooj. Cov bisphosphonates rau kev kho mob ntawm kab mob yog zoo, tshwj xeeb tshaj yog raws li ib tug prophylactic tus neeg saib xyuas nyob rau hauv menopausal cov poj niam.
   

Yuav tsum paub tias koj yuav tsum tsis txhob self-medicate, tshuaj yuav tsum tau muab los ntawm ib tug kws kho mob.

yooj yim bisphosphonates

Tsis muaj nitrogen bisphosphonate tshuaj rau kab mob no kuj nquag siv. Cov muaj xws li:

1. "Etidronate" nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj thiab tshuaj. nws yog feem ntau tus kws kho tsis tau tsuas yog txha, tab sis kuj rau Paget tus kab mob, hypercalcemia, uas tshwm sim nyob rau hauv lub keeb kwm yav dhau ntawm cancer.
2. "Clodronate" yog muab nyob rau hauv daim ntawv ntawm cov tshuaj, ntsiav tshuaj thiab cov kev daws. Pib txha thiab osteolysis.
3. "Tiludronate" feem ntau yog tshuaj tsuas yog rau cov neeg laus uas raug kev txom nyem los ntawm tus kab mob Paget. Cov me nyuam, nws yog txhob.
   

Nws yog ntseeg hais tias cov no ob pab pawg ntawm cov tshuaj muaj sib txawv los rau cov txiv neej thiab poj niam lub cev, thiaj li zoo nkauj poj niam zoo suited nitrogen-muaj tshuaj. Nyob rau hauv txhua rooj plaub, cov kev xaiv yog yuav ua li cas xwb koj tus kws kho mob.

Miv nyuas siv zug nyob rau hauv ntau yam kab mob

Muaj yog ib tug tag nrho daim ntawv teev cov kab mob uas bisphosphonate txoj kev kho yuav muaj ib tug zoo ntxim.

1. Txha.
2. Myeloma.
3. Deforming osteodystrophy.
4. Primary hyperparathyroidism.
5. Kev ua txhaum ntawm tus txheej txheem ntawm cov pob txha tsim.
6. Thaum cov pob txha metastases.

Txhua yam ntawm cov tej yam kev mob tsuas yog tus kws kho mob prescribes ib tug yeeb tshuaj, nws ntau npaum thiab ntev ntawm kev siv. Koom nyob rau hauv nws tus kheej-kev kho mob, tsuas ua mob rau hauv lub cev.

mechanism ntawm qhov kev txiav txim

Txij li thaum bisphosphonates rau txha tshuaj yog cov feem ntau lug siv, nws yog tsim nyog los pab yus lub mechanism ntawm lawv kev txiav txim.

Tag nrho cov hlwb nyob rau hauv peb lub cev yog tshiab tsis tseg, tib yam yuav hais txog cov pob txha. Nws yog khaws cia los ntawm ib tug nqi koj tshuav ntawm osteoblasts, uas yog lub luag hauj lwm rau lub synthesis ntawm cov tshiab cov ntaub so ntswg, thiab osteoclasts yog lub luag hauj lwm rau nws cov kev puas tsuaj. Yog li ntawd, BF cas txuj ci tseem ceeb es lub chaw ua hauj lwm ntawm osteoclasts, thiab nyob rau hauv tej rooj plaub txawm ua mechanism ntawm nws tus kheej puas tsuaj.

Nws yog hais tias tam sim no lub sij hawm, zaum tau tau tsis tau siab tau paub tseeb yuav ua li cas tswj bisphosphonates thaiv cov pob txha puas tsuaj. Nws yog tsuas yog lub npe hu hais tias cov tshuaj tej zaum yuav ua ke nrog hydroxyapatite nyob rau hauv cov pob txha feem, li no hloov cov dabtsi yog khoov pob txha.

Koj yuav tau nco ntsoov tias yog hais tias siv tau rau ib lub sij hawm ntev, uas rau kev kho mob cancer raws li nyob rau hauv cov kuj tsis ntev los no bisphosphonates siv los kho kab mob.

Bisphosphonates metastases

Nrog rau txoj kev loj hlob ntawm cancer los ib theem thaum mob hlwb tawg tam sim ntawd los ntawm tus thawj qog thiab nws kis thoob plaws lub cev. Thaum lub qhov chaw tshiab lawv yuav txuas thiab pib loj hlob, txoj kev metastases.

Cov pob txha cov ntaub so ntswg yog lossi tau tshiab, li ntawd, nws tsub kom qhov yuav ntawm tus kab mob los hematogenous. Thaum mob hlwb tau mus rau hauv lub hlwb pob txha, lawv txhob cuam tshuam txog lub cev interplay ntawm osteoclasts thiab osteoblasts, uas ua rau yus mus tsis meej txoj kev loj hlob ntawm cov pob txha cov ntaub so ntswg.

Txij li thaum txiav txim seb lub xub ntiag ntawm metastasis yog ib qhov nyuaj, vim hais tias nyob rau hauv thaum ntxov ua sawv, tus txheej txheem no tshwm sim suab tsis muaj cov tsos mob, nrog rau mob cancer yuav tsum xeem dhau ib txhij txhua xeem kom paub tias theem nrab foci.

Ntawm tag nrho kev kho mob metastases Bisphosphonates yog lug siv. Cov tshuaj yog heev yooj yim zam lub txim los ntawm cov neeg mob, lawv tsis tshua muaj tshwm sim.

Lawv yuav tsum tau ua ke nrog radiotherapy thiab cov kws khomob. Thaum uas siv cov xws tshuaj tau pom tias yuav txo tau nyob rau hauv cov xwm txheej ntawm cov pob txha metastasis nyob rau hauv lub mis mob cancer, thiab ntau yam myeloma.

Thaum muaj hypercalcemia uas yog yuav luag ib txwm nyob rau ntawm lub oncological kab mob, tshuaj muaj tus loj tshaj cov nyhuv hauv daim ntawv ntawm cov tshuaj thiab infusions. Zoo heev tau pom tau xws li "Zolendronovaya acid," "Pamidronate". Twb ib ob peb hnub tom qab pib ntawm kev kho mob ntsuam xyuas qhia normalizing ntshav calcium, thiab cov nyhuv yuav mob mus txog li ob peb hnub.

Cov tswv yim rau cov uas tau txais bisphosphonates

Yog hais tias koj tsis tau hnov txog bisphosphonates, nws yog dab tsi, qhia rau tus kws kho mob. Txais ntawm cov tshuaj yuav tsum tau nqa tawm raws li tej yam cov kev cai:

• Koj yuav tsum noj tshuaj tom qab awakening, tsawg kawg yog ib teev ua ntej ib tug noj mov.
• Ntxuav cia nrog dej kom ntau yuav tsum tau.
• Tsis txhob siv zapivaniya lwm kua, xws li kua txiv, tshuaj yej, kas fes. Lawv tiv thaiv qhov haum ntawm bisphosphonates.
• Tom qab qhov kev siv ntawm cov ntsiav tshuaj yuav tsis pw, yuav siv sij hawm txog ib nrab ib teev nyob rau hauv ib tug upright txoj hauj lwm mus effect cov hlab pas yog tsawg heev.
• Nws tsis pom zoo kom muab cov kev txais tos BF nrog calcium supplementation, magnesium, hlau thiab txhuas.

Yog hais tias koj ua raws li tag nrho cov tswv yim pom zoo, lub bisphosphonate yuav tsis coj leej twg kiag phiv.

Bisphosphonates rau txha: pros thiab cons

Nyob rau hauv cov kev kho mob ntawm kheev siv bisphosphonates rau txha. Cov tshuaj yog siv Attendance zoo rau ob leeg cov txiv neej thiab cov poj niam. Lub ntsiab zoo ntawm cov tshuaj tej zaum yuav muaj xws li:

• Nws tsis muaj cov tshuaj hormones.
• Tsis txhob ua rau kom txoj kev loj hlob ntawm cov hlab plawv tus kab mob.
• Phem hlav siv BF tsis kawm.

Tab sis nyob rau hauv tej tshuaj pleev yog ib txwm tau mus nrhiav ib tug yoov nyob rau hauv lub tshuaj pleev. Bisphosphonates, txawm lawv ua tau nyob rau hauv cov kev kho mob ntawm kab mob, yog tseem deb ntawm zoo meej. Ntev Entrainment ntawm kev txais tos yuav muab raws li nram no phiv:

• Adversely cuam tshuam rau daim siab thiab ob lub raum.
• Yog hais tias muab intravenously, nws yog yuav muaj hypocalcaemia.
• Nws tej zaum yuav cov hlab pas los yog plab rwj.
• Muaj pob rau hauv lub cev.
• Nyob rau hauv ib co muaj yog ib tug general tsis muaj zog, malaise, thiab xeev siab.
• Mob nyob rau hauv cov nqaij.
• Teeb meem tsis pom.
• Zawv plab los yog raws plab.
  

Peb tsis tau hais tias tag nrho cov ntawm cov undesirable los yuav tsum manifest nws tus kheej nyob rau hauv txhua txhua tus neeg mob, tiam sis koj yuav tsum paub txog lawv. Yog hais tias koj yog kws bisphosphonates, nws yog dab tsi, qhia rau tus kws kho mob, nws yuav xaiv tib cov tshuaj ntau npaum thiab ntev ntawm kev kho mob.

Tej tshuaj yog zoo nyob rau hauv cov kev kho mob ntawm kab mob thiab lwm yam kab mob. Ua ntej koj yuav muab ib yam tshuaj, tus kws kho mob yuav tsum tau nqa tawm ib daim ntawv ntsuam kom paub seb lub xeev ntawm metabolism hauv cov pob txha thiab calcium homeostasis, yog li tsis txhob xav txog tej yam koj tus kheej rau muab tshuaj nyob rau hauv pab pawg neeg no.

, Koj yuav tau ua ib tug noj qab nyob zoo txoj kev ua neej, ua raws li tag nrho cov tswv yim pom zoo ntawm cov kws kho mob, noj txoj cai kom tsis txhob muaj mus rau chaw uasi rau tshuaj. Tsuas yog nyob rau hauv cov ntaub ntawv no, koj skeletal system yuav zoo.