txauv bilirubin
Ua pa muaj nuj nqi muab tag nrho cov ntshav ntaub so ntswg ntawm lub cev tsim nyog tus nqi ntawm cov pa nqa los ntawm heev tshwj xeeb conveyor - hemoglobin - nyob rau hauv cov qauv ntawm cov ntshav liab. Txawm li cas los, cov hlwb muaj ib tug tsawg txoj sia luv, thaj 100-120 hnub. Tom ntej no lawv nkag mus rau kroverazrusheniya kabmob, qhov uas lawv tso tawm hemoglobin. Nws uake haptoglobin thiab tam sim ntawd thauj mus rau lub hlwb ntawm lub reticuloendothelial system rau ntxiv hloov dua siab tshiab mus rau ib tug uas tsis yog-tshuaj lom xim (direct bilirubin) thiab cais lub bile. Nyob rau hauv macrophages thiab histiocytes hemoglobin chiv decomposes rau biliverdin, uas yog ib tug plaub pyrrole rings txuas methane bridged. Thiab ntxiv, muaj yog nws yuav txo tau kom dawb bilirubin, uas yog tej cov nqaijrog conveyors thiab thauj mus rau lub siab. Nyob rau hauv nws cov parenchyma yog nws transformation mus rau hauv ncaj qha bilirubin, piv txwv li losis tswvyim dabtsi glucuronate rau nws pov tseg.
Lub luag hauj lwm ntawm cov kab mob
Indispensable luag hauj lwm nyob rau hauv ntxiv tshua rau qhov qee ntawm cov kua tsib pigments ua lub qub plab hnyuv microflora. Bilirubin mus ncaj los ntawm lub siab nyob rau hauv nyob tus yeees ntawm cov kua tsib nyob rau hauv lub vesica fellea, thiab thaum qhib faterova txiv mis nkag rau hauv lub duodenum, thiab ntxiv mus, nyob rau hauv cov hnyuv, qhov twg freed los ntawm glucuronic acid thiab hloov dua siab tshiab rau hauv sterkobilinogena outputting lub faeces. Ib feem ntawm nws thaum dhau los ntawm lub qhov quav yog absorbed rau hauv lub hemorrhoidal leeg nkag mus rau hauv cov hlab ntsha, bypassing lub siab, thiab tas los ntawm ob lub raum nyob rau hauv cov zis. Yog li, cov ntshav tsis tu ncua kuaj raws li dawb, thiab ncaj qha bilirubin. kawg tus nqi yog hais txog 5.1 mol / l, thiab tag nrho - 15.
Mob ntawm daim siab kab mob
Raws li cov ntseeg thiab tus piv ntawm cov indicators yuav raug txiav txim nyob rau hauv hauj lwm ntawm lub siab. Yog li ntawd, yog hais tias tus parenchyma ntawm lub cev muaj ib tug kab mob los yog tshuaj lom puas tsuaj, feem ntau ntawm cov dawb xim thiab tseem unbound, thiab cov concentration hauv cov ntshav ntawm ob yam ntaub ntawv ntawm cov xim nce dramatically. Direct bilirubin nyob rau hauv cov ntshav yog kuaj nyob rau hauv lub thiaj li hu obstructive daj ntseg, uas muaj cov obstacles rau li qub khiav ntawm cov kua tsib, thiab yog li ntawd cov kua tsib regurgitation tshwm sim nyob rau hauv cov hlab ntsha. Yog vim li cas rau qhov no yuav ua tau compression kua tsib ciav hlav ntawm lub pancreas lub taub hau, pob zeb, thiab lwm yam obliteration. Muaj suprarenal thiab daj ntseg, qhov ua rau ntawm uas yog kho kom zoo lwj ntawm hemoglobin nyob rau hauv cov hlab ntsha. Qhov no tej zaum yuav muaj kev cuam tshuam hemolytic toxins thiab microbial toxins, ib co ntawm cov physiological mob. Txawm li cas los, tag nrho cov hom ntawm tus kab mob siab bilirubin ua li nyob rau hauv cov ntaub so ntswg. Unbound tib vim hais tias ntawm nws cov lipophilicity, nws yooj yim penetrates mus rau lub hlwb, nrog rau cov los ntawm cov ntshav-hlwb barrier, thiab cais cov electron thauj saw nyob rau hauv lub mitochondria, li no inhibiting zog metabolism. Kev ruaj ntseg nyob rau hauv no hais txog, direct bilirubin, uas nws cai yog uas tsis yog-tshuaj lom, vim nws yog insoluble molecule.