Yuav ua li cas los tiv thaiv-TB tshuaj no yog qhov zoo tshaj plaws siv rau kev kho mob?

Undiagnosed pulmonary tuberculosis yuav kho nyob rau hauv ib lub sij hawm ntawm 10 hnub lub hlis mus rau 1.5 xyoo. Yuav ua li cas ntev yuav cov kev kho mob nyob rau hauv lub heev ntawm tus kab mob thiab lub sij hawm ntawm cov feem ntau tsim tailor-made tshuaj.

Mob Ntsws nyob rau hauv peb lub sij hawm - ib tug curable kab mob

Nyob rau hauv niaj hnub tuberculosis tshuaj tua kab mob kho yog cov prerogative ua ke nrog kev kho mob. Qhov no yog vim hais tias thaum twg ib tug-lub sij hawm tau txais daim ntawv los ntawm ntau yam tshuaj yog npaum li cas qeeb qeeb loj hlob mycobacteria kuj mus rau yeeb tshuaj. Tus neeg mob yog muab rau ib tug thaum kawg tam sim ntawd Teev 2 los yog 3 tshuaj. Qhov zoo ces, tus possibilities ntawm cov tshuaj hnub no yog nws kim heev. Qhov no yuav tsuas yuav ib tug xov tooj ntawm 1 TB tshuaj los yog ib tug ua ke ntawm chav formulations kuv thiab II series.

Ib suam ntawm anti-TB agents ua los ntawm cov neeg kawm ntawv ntawm cov hauj lwm zoo. Los ntawm txoj kev, muaj ntau yam ua tsaug rau peb cov kev tshawb fawb lub koom haum rau cov invention ntawm xws cov tshuaj raws li "INH". Qhov no yog ib yam ntawm cov loj anti-tuberculosis tshuaj, nws muaj lub zoo dua nyob rau hauv heev bacteriostatic kev ua si. Nyob rau hauv cov ntaub ntawv no, nws yog tshwj xeeb tshaj yog tsim cov txheej txheem nyob rau hauv tshiab khiv paub hais tias cov neeg mob.

Tom ntej no rau hauv daim ntawv

Qhov thib ob-hauj lwm zoo ntawm kev kho mob tom qab "Isoniazid" - yog "Rifampicin". Zoo nkauj heev thiab zoo txhais tau tias. Active tom ntej npaj yuav muab sau ua ke nyob rau hauv cov nram no ib theem zuj zus: "streptomycin", "Kanamycin", ntxiv "Pyrazinamide" "Ethionamide" ua raws li los ntawm "Prothionamide" "Ethambutol", thiab 3 ntau 'florimitsina "" Pask, "TB "Thioacetazone" tshuaj.

Tag nrho cov tshuaj vozdeystuyuschie rau Mycobacterium thiab pab daws tau kev soj ntsuam cov teeb meem ntawm cov neeg mob tau raug muab tso rau cov pab pawg neeg ntawm anti-TB tshuaj:

1. Tua loj anti-TB tshuaj 1 series
2. cia cov tshuaj II series.

Lub sib txawv npaj 1 thiab 2 kab

Nyob rau hauv lub thawj kab yog cov tseem ceeb cov tshuaj uas hais los lub siab tshaj plaws efficiency ntawm lub chemotherapeutic neeg thiab lawv derivatives. Muaj tsawg heev toxicity.

Antituberculosis tshuaj 2 kab, xws li ib tug backup tshuaj, tsis muaj xws li ib tug zoo tshwm sim nyob rau hauv combating Koch wand, nrog heev tshuaj lom. Lawv muab rau cov neeg mob nyob rau hauv rooj plaub yog hais tias tus lub cev yog impervious tshuaj naj npawb 1 los yog intolerance ntawm cov tshuaj yog cai.

Sad statistics qhia tau hais tias txhua lub sij hawm cov tshuaj yog hom los ntawm lub cev, i.e. lub efficiency yog zoo heev txo. Tsis tas li ntawd, lub ntsiab anti-TB tshuaj tom qab ib tug tej lub sij hawm, ua rau lawv tus kheej thiab hom vim hais tias mycobacteria ua tiv thaiv kab mob rau lawv. Piv txwv li, yog hais tias tus kev rho tawm yuav tsum tsuas yog ib qho kev tshuaj, ces kuj mus rau nws mycobacteria cai tsis pub dhau 2-4 lub hlis.

TB tshuaj: siv dag zog yuam thiab tej yam

Lub ib thooj ntawm cov tshuaj TB tawm tsam bacteriostatic ntxim rau mycobacteria, uas yog, lawv txo lawv virulence thiab suppress lub tseem mus muab. Ib yam li ntawd, lub "INH" thiab "Rifampicin" nyob rau hauv feeb meej koob muaj lub peev xwm mus ua bactericidal. Yog xav tau ruaj khov kho mob nyhuv, raws li zoo raws li mus rau ceeb toom thiab las mees tau rov muaj dua ntawm anti-TB tshuaj yuav tsum tau mus ntxiv rau ib ntev lub sij hawm.

Nrog rau tag nrho ntawm no xaiv thiab lub sij hawm ntawm qhov zoo tshaj plaws ua ke ntawm cov tshuaj, raws li zoo raws li lub caij ntawm lawv daim ntawv thov yog ncaj qha nyob rau hauv lub tsev ntawm tus neeg mob nyob rau ntawm lub sij hawm cov ntaub ntawv tuberculosis, los ntawm dab tsi txhais tau tias yog nqa tawm yav dhau los kho mob (yog tias muaj), raws li zam lub txim rau los ntawm tus neeg mob ntawm tej yam tshuaj los ntawm raws li Mycobacterium tuberculosis yog nkag mus rau lub xaiv tshuaj.

zoo tshaj plaws compatibility

Lub ua ke ntawm anti-TB tshuaj teem rau lub assumption tias cov kev kho mob pab cuam yuav tsum tam sim no ib tug los yog ob tug thawj-line tshuaj. Ntawm cov hoob kawm, yog hais tias lawv tsis muaj tej contraindications los yog tso saib lawv stability. Thaum no koob tshuaj tag nrho cov chav npaj yog feem ntau tsis txo.

Thaum muab (memo ftiziologa) yuav tsum tau coj mus rau hauv tus account hais tias xws li ib tug anti-TB yeeb tshuaj, raws li streptomycin thiab nws cov derivatives tsis tau ua ke nrog florimitsina, kanamycin thiab lwm yam tshuaj tua kab mob uas muaj nephrotoxic thiab ototoxic los.

Yuav ua li cas hom ntawm kev npaj "PAS"

"PAS" - TB tshuaj bacteriostatic los. Yog kav rau hnub zaum pharmacologists uas tsim nws. Heev active tiv thaiv cov kab mob TB bacilli. Pib nyob rau hauv cov kev kho mob ntawm ntau yam ntaub ntawv thiab ntau yam localizations ntawm tuberculosis. Nws muab ua twb zoo nyhuv thaum nws yog nrog lub sij hawm ntawm lwm yam tshuaj TB kev txiav txim.

Cov tshuaj muaj Latin lub npe "PASK-AKRI". Qhov yog nyob rau hauv lub hnab ntawm 4 g los yog 100 g ntawm lub tsev txhab nyiaj nyob rau hauv ib tug noj tshuaj hnab "PAS" muaj 3.2 aminosalicylate sodium, raws li nyob rau hauv ib ntsiav tshuaj - 1 g ntawm sodium para-aminosalicylate. Cov ntsiav tshuaj them nrog ib tug plhaub tiv thaiv lub plab thiab nyob rau hauv lub qhov muag yog muab tso rau 50/100/500/1000 daim. nyob rau hauv lub pob.

Yuav ua li cas zoo dua mus ua ke

TB tshuaj "PAS" nyob rau hauv cov nqe lus ntawm kev ua si tuberkulostaticheskoy ua tsis tau zoo tshuaj xws li Isoniazid thiab streptomycin, thiab vim hais tias nws yuav tsum tau siv nyob rau hauv ua ke nrog ib tug ntau yam tshuaj mas siv. Thaum lawv tseem kho slows cia txoj kev loj hlob ntawm cov tshuaj kuj thiab tej cov nyhuv ntawm concomitant tshuaj.

Tshuaj "PAS"

Cov tshuaj muaj ib tug high (90%) ntawm cov haum. Nws yog metabolized nyob rau hauv lub siab. Tau yooj yim mus rau cov ntshav-cov ntaub so ntswg teeb meem thiab faib nyob rau hauv cov ntaub so ntswg. Qhov siab tshaj plaws nqi ntawm cov tshuaj concentration cai nyob rau hauv lub ntsws, ob lub raum thiab lub siab. Ntau mob pesnrab "PAS" (antituberculosis yeeb tshuaj) penetrates mus rau hauv hlwb txha nqaj qaum kua. Tab sis nyob rau hauv cov ntaub ntawv ntawm o nyob rau hauv lub hlwb txha nqaj qaum kua zoo li aminosalicylic acid concentration yog 10-50% ntawm cov concentration hauv cov ntshav ntshav. Feem ntau cov (80%) ntawm cov tshuaj tas mas nyob rau hauv cov zis.

Npaj II series

2 anti-TB tshuaj ntawm ib tug xov tooj ntawm lawv xaiv thiab raws sij hawm lub sij hawm muaj ib tug zoo heev kho nyhuv nyob rau hauv cov nqe lus ntawm detoxification, ntxiv kuj yog ib tug tseem ceeb regression ntawm inflammatory kev hloov nyob rau hauv lub ntsws ntaub so ntswg, thiab txawm nyob rau hauv kev kho tus kab mob ntsws ntawm lub bronchi.

Raws li kev kho mob kev tshawb fawb thaum lub sij hawm kev kho mob ntawm cov me nyuam thiab cov laus uas nyuab, mob thiab puas ntaub ntawv ntawm tshwm sim ntawm tus kab mob ntsws muaj ntau yam kev ob peb ua ke ntawm cov tshuaj ntawm ob peb II ntawm, muab tus neeg mob cov kev soj ntsuam tsis kam, thiab resistant kab mob los ntawm cov kab mob mus rau lub tshuaj kuv series, nyob rau hauv 65 feem pua ntawm cov neeg mob uas nws tau txais, uas yog heev pleasing , ntxiv kev soj ntsuam cov nyhuv.

TB tshuaj: phiv

Thiab, ntawm chav kawm, xav nyob rau hauv cov noj tshuaj yog piav nyob rau hauv tsab xov xwm, lawv tau phiv. Tshwj xeeb tshaj yog vim hais tias ntawm lub nkag mus rau hauv xyoo tsis ntev los nyob rau hauv txoj kev xyaum ntawm cov tshuaj anti-TB tshuaj yuav tsum tau txais tshwj xeeb kev saib xyuas. Qhov no yog vim lub fact tias tus kab mob no yuav sai sai no hla tus phaum mob pib, txawm tseem ceeb tom qab lub ntiaj teb no ua tsov ua rog II los txo morbidity theem. Tsis tas li ntawd ib qho tseem ceeb yog qhov tseeb hais tias lub kev kho mob ntawm tuberculosis, raws li hais saum toj no, cov txheej txheem yog heev ntev, thiab tsis zoo feem ntawm cov tshuaj cia li manifested nws tus kheej, los yog ib tug overdose los yog thaum lub sij hawm lub caij nyoog nws txais tos.

Ib txhia txheeb cais

Thaum tus kab mob TB txoj kev kho ceeb toom txog kev ntaub ntawv txawv teb chaws thiab domestic cov neeg sawv cev cov tshuaj phiv los ntawm cov tshuaj thiab lawv zaus ntawm tshwm sim thiaj li varied li qhov xwm ntawm tus kab mob no. Piv txwv li, los ntawm 3148 tus neeg mob nyob rau hauv kev kho mob uas muab kev koom tes cov neeg ua hauj active tiv thaiv mycobacteria, phiv tshuaj muaj cai nyob rau hauv tsuas 12.2% ntawm cov neeg, nrog rau feem ntau ntawm lawv yog cov manifestation ntawm kev tsis haum xwm, thiab tsuas yog nyob rau hauv 74 cov neeg mob muaj yog ib tug tshuaj lom lom.

Raws li luam tawm cov ntaub ntawv, peb yuav xaus uas lub cai tshwm sim los ntawm anti-TB tshuaj sib txawv zaus cov lus teb. Loj hloov mus hloov los yog piav los ntawm lawv cov uas tsis yog niaj hnub zoo li kev kho mob ntawm tej yam kev mob uas yog ib qho tseem ceeb tsis tau tsuas yog siv tshuaj, tab sis kuj yog ib tug hauv daim ntawv ntawm tuberculosis, raws li zoo raws li lub hnub nyoog ntawm cov neeg mob, txawm lub hom ntawm kev kho mob chaw (tsev kho mob, sanatorium, chaw kuaj mob, tsev kawm ntawv).

kev tshawb fawb tseem

Cov tshuaj muaj teeb meem rau Koch lub Bacillus, muaj xws li ib tug xov tooj ntawm tej yam ntuj tso thiab semi-hluavtaws tebchaw nyob rau hauv uas yog ib tug tshaj plaws nyob rau hauv ntau - nws yog lawv cov kev ua tiv thaiv, piv txwv li Mycobacterium tuberculosis (M.tuberculosis). TB tshuaj, ib tug kev faib uas, raws li hais ua ntej lawm nyob rau hauv no tsab xov xwm, faib cov tshuaj mus rau hauv 2 series (thawj thiab thaub qab), yog zoo txaus siab mus zaum.

Kev mloog yog txoj kev loj hlob ntawm kuj ntawm lub TB bacilli. Tag nrho cov kuaj tshawb yog nqa tawm, thiab nyob rau hauv no qhov teeb meem ntawm kev soj ntsuam pom tias feem coob ntawm cov neeg mob cov neeg kawm ntawv ntawm cov tshuaj kuj thaum lub sij hawm kev kho mob tej zaum yuav sib txawv, thiab upward thiab downward, xeeb ntawm lub sij hawm mus yuav luag tiav restoration ntawm rhiab heev.

Yuav txo tau kev phiv tshuaj

Thaum phiv xwm txheej tshwm sim thaum lub sij hawm kev kho mob, cov thawj koob tshuaj ntawm cov tshuaj yuav tsum tau txo los yog yuav hloov tau ib co lwm yam npaj. Rau hauv loj heev cov ntaub ntawv sab cov tshuaj tiv thaiv antituberculous tshuaj los mus ib ntus txwv tsis pub txais tos tom hloov los ntawm lwm lub. Nyob rau hauv thiaj li yuav tiv thaiv thiab tshem tawm cov tsos mob ntawm coronary mob plawv tus neeg mob yog muab nyob rau hauv lub pov thawj ntawm tej yam ntawm ib tug xov tooj ntawm cov tshuaj antispasmodics, xws li: "Eufillin", "papaverine", "Teofedrin" rau "Zelenin," thiab lwm yam ...

Cov yam ntxwv thiab qhov kev phiv cov txheej xwm thaum lub sij hawm tus kab mob TB kev kho mob yog heev ntau haiv neeg. Antituberculosis tshuaj, kev faib nyob rau hauv uas cov kev ua kom paub txog yam tshuaj feature, grouped ua ke kom pab txhawb kev tshawb fawb.

TB kev kho mob

Nyob rau hauv cov kev kho mob ntawm tuberculous kab mob nyob rau hauv peb lub sij hawm nws yog tseem xam tau tias yog ib qho tseem ceeb ua hauj lwm los mus tiv thaiv kev kis tus kab mob. Cov kev hem thawj los ntawm tus neeg mob nrog pulmonary tuberculosis nyob rau hauv ib qho qhib daim ntawv. Lawv intensive kev kho mob yuav pab txo tau cov naj npawb ntawm cov kab mob, raws li tau zoo raws li nyob rau hauv cov kev tiv thaiv ntawm cov tshiab tus neeg mob no tsis kaj siab tus kab mob.

Txij li thaum long-term kev kho mob, tus neeg mob yuav siv sij hawm ib tug ntau ntawm kev ua siab ntev thiab samodistsiplinirovannost. Tseeb, tuberculosis yog dejnum tsis tau tsuas yog ntaus los ntawm lub cev, tab sis kuj thoob plaws lub cev raws li ib tug tag nrho. Heev tseem ceeb lub sij hawm rau pib antimicrobial txoj kev kho, nyob rau hauv uas lub chav kawm yog lub feem ntau haib artillery, lub estosnovnye TB tshuaj. Ua tsaug rau lawv, tsis tau tau txiav bacilli nyob rau hauv thaum ntxov ua sawv, uas yuav ua rau kom lub kho tshiab ntawm lub cov hloov nrog me me los yog tsis muaj kev puas tsuaj rau lub tag nrho kab mob.

Comprehensive kev kho mob yuav tsum tau muab noj mus rau hauv tus account lub hnub nyoog thiab lub qhia tau ntaub ntawv ntawm tus kab mob, xws li los rau hauv lub pathological kev ntawm ib tug mob hloov khoom nruab nrog, kom txhob muaj cov concomitant cov tsos mob (mob, hnoos) nrog txawv inhalations thiab lub cev txoj kev kho kev kawm.

Nkag xws pab pawg neeg ntawm cov tshuaj yuav tsum tau yuav ib tug tsis tu ncua li cov shotgun mus kom ze yuav ua rau txoj kev loj hlob ntawm kuj mus rau lawv. Kev kho mob yuav tsum tau ua nyob rau hauv ib tug lub tsev kho mob nyob rau hauv lub saib xyuas ntawm ib tug kws kho mob. Tom qab paug phthisiatrician ua tib zoo saib xyuas.

Loj mus kom ze thiab siv ntawm kev kho mob tshuaj thiab lub hom phiaj yog tus yuam sij mus ua kom tiav rov qab. Niaj hnub no tus kab mob TB no tsis yog ib kab lus.