Plawv: ib tug saib xyuas ntawm cov tshuaj, thiab cov hauj lwm zoo ntawm cov lus teb

Cardiotonic agents yog cov tshuaj uas ua rau kom cov kev ua ntawm kev ua hauj lwm ntawm cov kev mob plawv, nws contractile muaj peev xwm thiab siv nyob rau hauv cov kev kho mob ntawm lub plawv tsis ua hauj lwm. Cov pab pawg neeg no muaj xws li ib tug tseem ceeb npaum li cas ntawm cov tshuaj uas txawv active tshuaj nyob rau hauv muaj pes tsawg leeg thiab ib tug txawv mechanism ntawm qhov kev txiav txim. Cardiotonic siv rau cov kev kho mob ntawm mob thiab ntev ntaub ntawv ntawm lub plawv tsis ua hauj lwm.

Plawv: lub kev faib

Tag nrho cov nyhuv ntawm tag nrho cov tshuaj nyob rau hauv cov pab pawg neeg, raws li nyob rau hauv lub peev xwm yuav ua tau kom tus quab yuam ntawm myocardial contraction, li no ua mob rau cov zis thiab ntshav stroke volume. Cardiotonic cov neeg ua hauj txo lub diastolic volume, pulmonary thiab mauj venous siab, thiab lub siab thaum lub sij hawm lub txhaws ntawm lub ventricles.

1. Plawv glycosides - "Strofantin", "Korglikon", "Digoxin".
2. Adrenergic tshuaj - "Izadrin", "Dobutamine", "dopamine".
3. Adrenergic hluavtaws tshuaj - "Amrinon", "Milrinone".

Xaiv siv tshuaj txuam nrog rau heev ntawm tus neeg mob tus mob thiab hauv daim ntawv ntawm tus kab mob no thaum kawg.

mob glycosides

Cov pab pawg neeg yog sawv cev los ntawm txoj kev ntawm zaub los yog hluavtaws keeb kwm. Formulations raws li nyob rau hauv tshuaj muab los ntawm kev cog digitalis, goritsveta, Lily caij nplooj ntoos hlav, oleander, strophanthus li al.

Lub caij kho txiav txim, cia hnab khib nyhuv nyob rau hauv lub cev, thiab neurotoxicity tshuaj yog kiag li nyob rau lawv muaj peev xwm mus tsim ntau ceg nrog cov ntshav proteins. Lub muaj zog xws li ib tug kev twb kev txuas, ntau dua qhov lub efficiency ntawm lub glycoside. Plawv no pab pawg neeg muaj ib tug txiav txim raws li nyob rau hauv cov nram qab no mechanisms:

• shortening systole tshwm sim ib txhij nrog nws nce;
• sij hawm so ntawm lub plawv mob yog lengthened;
• poob lub plawv dhia;
• myocardial nqaij enhanced muaj peev xwm excitation;
• Yog hais tias overdose yog tsim ventricular fibrillation.

"Digoxin"

Cov tshuaj no yog tsim los ntawm cov nplooj ntawm digitalis. Nws yog hais txog rau qhov ntev-sawv glycosides, tsis muab kev phiv loj heev. Nws yog siv rau txoj kev kho mob ntawm tus kab mob plawv tsis ua hauj lwm thiab arrhythmia tachysystolic.

Muaj raws li cov ntsiav tshuaj thiab tshuaj tov. Cov koob tshuaj yuav tsum tau xaiv kom zoo zoo rau txhua tus neeg mob ib lub zuj zus. Nyob rau hauv cov ntaub ntawv ntawm lwm yam mob glycosides ua ntej "Digoxin" ntau npaum decreases.

"Strofantin"

Plawv glycoside yog ib tug luv luv-acting, siv nyob rau hauv cov ntaub ntawv ntawm mob ntaub ntawv ntawm tus kab mob. "Strofantinom" yog tsis peculiar rau noog nyob rau hauv lub cev. Cov kev npaj pab contractile muaj nuj nqi ntawm lub myocardium thiab ua rau kom mob tso zis. Nyob rau hauv parallel, muaj yog yuav txo tau nyob rau hauv lub loj ntawm lub plawv mob thiab txo nws cov pa thov.

Muab intravenously, intramuscularly, nyob rau hauv tej rooj plaub - nyob rau hauv. Haus loj nyiaj yuav ua tau kom ib tug overdose. Kev siv ntawm lwm yam tshuaj hloov cov hauj lwm zoo ntawm cov glycoside:

• barbiturates nyhuv yog txo;
• nrog "reserpine", sympathomimetics thiab antidepressants yuav ua rau txoj kev loj hlob ntawm mob arrhythmias;
• txais tos nrog tetracyclines, "chloramphenicol", "Amiodarone" thiab "captopril" thiab txhawb nqa qhov mob txiav txim;
• magnesium sulfate yeej txhawb lub plawv atrioventricular block.

adrenergic tshuaj

Neglikozidnye cardiotonic agents muaj ib tug luv luv lub sij hawm txiav txim. Cov pab pawg neeg siv nyob rau hauv lub mob chav kawm ntawm lub plawv tsis ua hauj lwm los pab txhawb qhov tseem ceeb functions ntawm lub cev.

"Izadrin" yog ib hom adrenergic hlab ntsha, bronchi thiab lub plawv. Cov tshuaj muaj ib tug hypotensive nyhuv, tsub kom lub contractile muaj peev xwm ntawm cov kev mob plawv. Siv nyob rau hauv mob contractility nrog ib tug ntse txo nyob rau hauv kev khiav hauj lwm ua ub no, raws li zoo raws li nyob rau hauv cardiogenic poob siab. Xyuas ntawm cov kws kho mob ceeb toom hais tias cov tsis ncaj ncees lawm daim ntawv thov los yog tshaj koob tshuaj yuav ua rau ventricular fibrillation ntawm lub plawv.

"Dobutamine" - cardiotonic neglikozidnye qauv, muaj ib tug stimulating nyhuv on lub plawv mob thiab coronary ntshav normalizing. Cov kev pheej hmoo ntawm arrhythmias thaum uas siv cov cuab tam yog heev tsawg, vim hais tias "Dobutamine" muaj zoo tsis ntxim rau mob automaticity.

Yam uas luag muab lug txhim khu cov contractility ntawm lub myocardium thaum lub sij hawm sai tsim nyog. Nyob rau hauv tej rooj plaub, tej zaum nws yuav ua rau txoj kev loj hlob ntawm sab los:

• xeev siab;
• mob taub hau;
• tawg;
• tachycardia;
• mob tom qab lub breastbone.

"Dopamine" yog ib tug catecholamine stimulating adrenergic receptors. Cov tshuaj seb puas tsimnyog tau cov ntshav siab, tsub kom coronary ntshav txaus. Nws yog qhia rau mob myocardial tsis ua hauj lwm, poob siab. Ceev faj yuav tsum tau siv nyob rau hauv myocardial infarction, cev xeeb tub, cov thyroid kab mob, arrhythmias.

Adrenergic hluavtaws cardiotonic

Nws yog siv nyob rau hauv cov ntaub ntawv ntawm mob coronary insufficiency, mob chaw. Tshuaj ua rau lub contractility ntawm lub plawv mob, ua nws. Yuav ua rau txoj kev loj hlob ntawm arrhythmias thiab tej ntshav siab, mob ntawm lub raum.

Plawv tshuaj nyob rau hauv pab pawg neeg no yuav siv tsis tau nrog lub plawv tsis xws luag, raws li zoo raws li cardiomyopathy, mob atherosclerosis teeb, aortic aneurysm, raum tsis ua hauj lwm, lub plawv nres thiab thaum lub sij hawm nyuam.

Txhais tau hais tias "Amrinon" yog siv heev dua lwm yam nyob rau hauv lub ICU, tus neeg mob twb khaws cia nyob rau hauv cov kev tswj ntawm tshwj xeeb pab kiag li lawm, taw nws lub xeev. Nyob rau hauv tas li ntawd mus ntxiv kom lub plawv dhia npaj expands cov hlab ntsha, tsub kom ntshav ncaws thaum lub sij hawm systole thiaj pulmonary siab.

Nws yuav ua raws li ib tug tshuaj. Tso dej raws leeg tsis tshua muaj neeg diluted nyob rau hauv physiological sodium tshuaj dawb tov. Yuav tsum tsis txhob muab tov nrog lwm yam tshuaj. Nrog rau cov kev taw qhia uas tau ntse poob nyob rau hauv siab, muaj zog lub plawv dhia, arrhythmia, mob taub hau, gastrointestinal mob.

"Milrinone" yog ntau yam tshaj li tus thawj neeg sawv cev ntawm cov pab pawg neeg, thiab raws li kev xyuas zoo taus los ntawm cov neeg mob. Txhob siv cov tshuaj thaum lub sij hawm cev xeeb tub thiab cov kev loj hlob ntawm myocardial infarction. Nws muaj xws li kev npaj ntawm pab pawg neeg A. Qhov yuav tsum tau rau cov nyiaj yog txiav txim thiaj tau tuaj los ntawm koj tus kws kho mob.

xaus

Plawv muaj pov thawj cov hauj lwm zoo ntawm ib tug ob peb tiam dhau los. Xyuas qhia hais tias qhov no pab pawg neeg ntawm cov tshuaj los pab tiv nrog lub plawv tsis ua hauj lwm. Txawm li cas los, kev noj cov tshuaj no nyob rau hauv daim ntawv ntawm nws tus kheej-kev kho mob yog nruj me ntsis txhob vim hais tias ntawm tau teeb meem, phiv los sis overdose. Qhov kev xaiv ntawm cov tshuaj, raws li zoo raws li lub koob txais kev kho plawv txiav txim nyob rau hauv txhua tus neeg soj ntsuam cov ntaub ntawv.