"Mesakol": cov lus qhia rau kev siv, tiag tiag counterparts

Ulcerative mob plab thiab Crohn tus kab mob muaj cai nyob rau hauv cov neeg mob yog heev tsis tshua muaj. Tab sis, dua li no, muaj ntau ntau cov tshuaj uas yog npaj los kho cov kab mob. Ib tug ntawm lawv yog "Mesakol". Cov lus qhia rau kev siv, daim ntawv, tswv yim, thiab tus nqi ntawm cov nyiaj yuav tsum hais hauv qab no.

Muaj pes tsawg leeg, qhov kev tso tawm daim ntawv no, ntim thiab cov hauj lwm

Tshuaj "Mesakol", xyuas uas yog heev tsis meej xwm cim, mus rau cov muag khoom raws li ib tug liab-xim av ntsiav tshuaj. Lawv yog cov enteric-coated thiab muaj ib tug yeej thiab lenticular daim ntawv.

Lub ntsiab yam khoom uas ntawm lub cuab tam protrudes mesalazine (5-ASA). Nyob rau hauv tas li ntawd mus rau nws ntawm cov tshuaj muaj xws li ntxiv Cheebtsam xws li pob kws starch, calcium phosphate dihydrate, talc lim, microcrystalline cellulose, titanium oxide, hypromellose 2208, silica colloid, povidone K90, sodium carboxymethyl starch, lub copolymer acid methacrylic thiab methyl methacrylate, liab hlau oxide, macrogol 6000 thiab dibutyl phthalate.

Ntsiav tshuaj "Mesakol" manufactured nyob rau hauv txhuas ib daim hlab thiab cov duab los qhia packs feem.

pharmacology

Koj puas paub hais tias yog ib tug yeeb tshuaj "Mesakol"? Cov lus qhia rau kev siv qhia hais tias qhov no anti-inflammatory tus neeg saib xyuas, cov nyhuv uas yog laus nyob rau hauv cov hnyuv. Qhov no vaj tse ntawm lub medicament vim nws muaj peev xwm inhibit tus synthesis of leukotrienes thiab prostaglandins, thiab Neutrophil lipoxygenase.

Peb kuj yuav tsum nco ntsoov tias qhov suav hais tias cov tshuaj slows tsiv teb tsaws, phagocytosis thiab degranulation qe, raws li zoo raws li immunoglobulin secretion los ntawm lymphocytes.

Yuav ua li cas lwm yam khoom muaj ib tug kho "Mesakol", tus nqi ntawm uas yog qhia hauv qab no? Mesalazine muaj antimicrobial kev ua si tiv thaiv ib txhia cocci thiab Escherichia coli (nyob rau hauv cov nyuv).

tshuaj

Yuav ua li cas yog lub xam qhovkev kev tig tau tsis ntsiav tshuaj "Mesakol"? Cov lus qhia rau kev siv hais tias tom qab cov thawj coj los mesalazine yog tso tawm los ntawm lub plhaub tom qab txog 115-165 feeb, thiab tom qab 170-230 feeb ntsiav tshuaj yaj.

Vim xav tshuaj zaj duab xis loj rau 60-80% yog tso tawm nyob rau hauv txoj hnyuv loj, thiab 15-30% - nyob rau hauv cov hnyuv. Nyob rau hauv rooj plaub no tus active tshuaj nce mus txog lub mauj kev xwb nyob rau hauv ib tug npaum li ntawm 10% ntawm cov tshuaj. Mesalazine concentration nyob rau hauv cov ntshav yog tsawg heev li.

Kev sib txuas lus ntawm lub active ingredient rau ntshav cov nqaijrog yog 43%. Xam tias yog ib tug yeeb tshuaj thiab nws cov metabolites rau hauv niam cov kua mis.

Metabolism hauv mesalazine ua nyob rau hauv cov hnyuv thiab daim siab. Qhov no ua N-acetyl-5-aminosalicylic acid.

Lub ib nrab-lub neej ntawm 60-120 feeb (nyob ntawm seb lub koob). Tso tawm cov tshuaj mob raum thiab los ntawm cov hnyuv.

Indications yuav tau txais tshuaj

Uas hlub cov kab mob ntawm cov tshuaj "Mesakol"? Xyuas ntawm cov kws kho mob qhia tias qhov cuab tam heev zoo manifests nws tus kheej nyob rau hauv Crohn tus kab mob thiab ulcerative mob plab.

Nws yuav tsum tau muab sau tseg hais tias qhov suav hais tias medicament yog siv tsis tsuas yog rau cov kev kho mob ntawm lub aforementioned kab mob tab sis kuj rau kev tiv thaiv ntawm exacerbations.

Contraindications tshuaj

Prescribers "Mesakol" tsis pom zoo:

• nyob rau hauv peptic rwj ntawm lub digestive system;
• ntshav kab mob;
• mob loj heev raum insufficiency;
• hemorrhagic diathesis;
• nyob rau hauv thaum yau;
• mob loj heev hepatic puas;
• npau taws me ntsis rau cov khoom xyaw tshuaj;
• tsis muaj glucose-6-phosphate dehydrogenase.

Nrog zoo saib xyuas cov tshuaj siv nyob rau hauv lub me me mus rau ntsis heev ntawm lub raum tsis ua hauj lwm, raws li zoo raws li tsawv thiab me me hepatic insufficiency.

Ntsiav tshuaj "Mesakol": cov lus qhia rau kev siv

Ntawm cov nyiaj coj lus xwb tom qab ib tug noj mov.

Thaum lub sij hawm exacerbation ntawm tus kab mob nws yog muab nyob rau hauv ib tug npaum li ntawm 400-800 mg (i.e., 1-2 ntsiav tshuaj) peb zaug ib hnub twg. Cov kev kho yog nqa tawm rau 9-12 lub lis piam.

Rau kev tiv thaiv ntawm exacerbations ntawm yeeb tshuaj siv los ntawm 400 mg peb zaug ib hnub twg. Cov ntsiav tshuaj no yog feem ntau nyob rau hauv daim ntawv ntawm cov, haus zoo tib yam dej.

Yuav ua li cas mus muab cov me nyuam ib tug yeeb tshuaj "Mesakol"? Taws tswm ciab, microclysters thiab ncua kev kawm ntawv - nyob rau hauv daim ntawv no yog qhia cov tshuaj rau cov me nyuam.

phiv tshua

Tu siab, noj tshuaj xam tau tias yog feem ntau heev ua rau kev phiv. Cov no muaj xws li nram qab no:

• pericarditis, tachycardia, mob conduction mob, kub siab, mob hauv siab, hypotension, palpitations, ua tsis taus pa;
• xeev siab, tsis qab los noj mov, ntuav, nce nyob rau hauv daim siab transaminases, kub siab, stomatitis, raws plab, kab mob siab, mob plab, pancreatitis, qhov ncauj qhuav;
• oliguria, proteinuria, crystalluria, hematuria, nephrotic syndrome, anuria;
• kiv taub hau, mob taub hau, hallucinations, tinnitus, insomnia, polyneuropathy, convulsions, co, kev nyuaj siab;
• eosinophilia, thrombocytopenia, anemia (haemolytic, aplastic, los yog megaloblastic), agranulocytosis, anemia, hypoprothrombinemia;
• oligospermia, impotence;
• tsis muaj zog, photosensitivity, mumps, txo zus tau tej cov kua muag kua, lupus zoo li syndrome, alopecia;
• daim tawv nqaij ua pob ua xyua, dermatitis, pruritus, bronchospasm, erythema.

Cov tsos mob ntawm overdose

Cov tsos mob overdose xam tau tias yog txhais tau tias protrude tej yam kev mob xws li xeev siab, gastralgia, ntuav, tsaug zog thiab tsis muaj zog. Yuav kom tshem tawm lawv yog tshuaj pais plab lavage, cov tshuaj ntaus cev thiab symptomatic txoj kev kho.

Compatibility nrog rau lwm cov khoom

Tshuaj "Mesakol" thiaj li muaj cov nyhuv ntawm "spironolactone" "Furosemide", "rifampicin" thiab sulfonamides. Nws kuj tej hypoglycemic los ntawm sulfonylurea derivatives, lub toxicity ntawm methotrexate thiab corticosteroids ulzerogennosti.

Nws yuav tsum tau muab sau tseg kuj tau hais tias cov tshuaj slows qhov haum ntawm cyanocobalamin thiab kuj yuav tsub cov nyhuv ntawm uricosuric agents (ie, blockers tubular secretion) thiab tej cov nyhuv ntawm anticoagulants.

tej tswv yim pom zoo

• Zawv plab tshwm sim thaum lub sij hawm kev kho mob "Mesakolom" tsis yeej ib txwm nyiam cov sab nyhuv ntawm cov tshuaj. Xws li ib tug mob tej zaum yuav ua tau ib tug kos npe rau ntawm lwm tus kab mob.
• Thaum lub sij hawm txais tos, lub cuab tam yuav tsum tsis tu ncua nqa tawm ntau cov ntshav thiab zis kev ntsuam xyuas.
• Yog hais tias cov tshuaj tau mus ntsib tsis tau, cov nram qab no yuav tsum tau coj lwm lub sij hawm.
• Thaum lub sij hawm kev kho mob nrog cov tshuaj no thiab tus neeg mob cov zis kua muag kua tej zaum yuav dawb lias nyob rau hauv ib tug daj-txiv kab ntxwv xim.

Tshuaj "Mesakol": counterparts thiab nqi

Hloov cov hais tias cov tshuaj yuav ua tau los ntawm txhais tau tias xws li "salazopiridazina", "5-ASA", "Tidokol" "Asacol", "Samezil", "salofalk", "Mesalazine", "Salozinal", "pentasil".

Yuav ua li cas npaum li cas yog cov "Mesakol" ntsiav tshuaj? Tus nqi ntawm cov tshuaj no yog 600-680 rubles (50 ntsiav tshuaj).

neeg xyuas

Cov neeg mob tawm hauv lub "Mesakol" npaj yog heev mixed xyuas. Ib txhia ntawm lawv qhia tias cov tshuaj zoo, khoom plab hnyuv kab mob. Lwm tus neeg cam hais tias cov tshuaj yog useless. Yog li, peb yuav xyuam xim xaus hais tias "Mesakol" nyias muaj nyias los ntawm cov sib txawv cov neeg mob.

Lub ntsiab drawback ntawm cov tshuaj no yog cov loj tus naj npawb ntawm contraindications thiab phiv tshua.