Lipid peroxidation (LPO) yog ib tug tseem ceeb heev link nyob rau hauv lub metabolic pauv. Cov yooj yim muaj nuj nqi ntawm nws yog los mus hloov cov lipids ntawm cell week.
Nyob rau hauv ib tug neeg noj qab nyob lipid peroxidation tswj los ntawm thiaj li hu ua antioxidant system uas regulates lub ceev thiab ntsev ua si los ntawm kev ruaj provoking yam los yog neutralize txaus qhov ntau ntawm peroxides los mus tiv thaiv ib tug overabundance kawg khoom ntawm metabolism. Amplification oxidation txheej txheem tej zaum yuav pib taw tes nyob rau hauv lub pathophysiological dab tseem ceeb nqi cov kab mob. Qhov no txoj kev no muaj xws li ib kauj ruam ntawm enzymatic thiab uas tsis yog-enzymatic autoxidation.
hom
Yuav kom hloov cov phospholipid bilayer ntawm lub cell daim nyias nyias extends enzymatic oxidation. Nyob rau hauv tas li ntawd, nws yog muab kev koom tes nyob rau hauv lub tsim ntawm biologically active tshuaj, detoxification, metabolic tshua. Tsis-enzymatic oxidation puas manifests nws tus kheej raws li ib tug puas tau nyob rau hauv lub neej ntawm lub cell. Vim tus tsim ntawm loj nyiaj ntawm cov dawb radicals thiab peroxides txuam nrog antioxidant system ua si decreases thiab raws li ib tug tsim nyog tau, yog kev puas tsuaj ntawm kab hlwb.
PAUL voj voog
Yuav pib lipid peroxidation tsim nyog muaj cov pa dawb radicals, muaj lub zog ntawm cov huab ib unpaired electron. Tom qab rov qab los ntawm cov pa molecules ua superoxide uas reacts nrog hydrogen atoms, xa mus rau hauv hydrogen peroxide. Rau kev tswj tus nqi ntawm cov superoxide hauv hlwb nyob superoxide dismutase, txoj kev ua hydrogen peroxide thiab catalase, peroxidase neutralize nws mus rau dej. Yog hais tias ib tug nyob kab mob raug ionizing tawg, tus xov tooj dawb hydroxyl radicals yuav ua rau kom dramatically. Tsis tas li ntawd hydroxide oxygen thiab nws lwm yam kom nquag plias ntaub ntawv tej zaum pib lub startup txheej txheem ntawm lipid peroxidation.
Cov khoom ntawm lipid peroxidation los yog kab mob pov tseg, los yog siv rau cov synthesis ntawm prostaglandins (tshuaj muab kev koom tes nyob rau hauv o tshua), thromboxanes (muaj thrombogenic cascade kev tshua), adrenal cov tshuaj hormones.
tswj system
Nyob rau hauv lub cell daim nyias nyias qauv base ceev, thiab tus nqi ntawm cov kev ua si ntawm lub resulting oxidation khoom tej zaum yuav txawv. Piv txwv li, cov kev ua ntawm lipids peroxidation saum toj no qhov twg ib tug yog ib feem ntawm lub cell phab ntsa yog yeej unsaturated fatty acids, thiab qeeb qeeb, yog lub hauv paus ntawm lub COP yog cholesterol. Tsis tas li ntawd, qhov zoo tshaj yuav tswj tus nqi thiab tus nqi ntawm tsim ntawm free oxygen radicals, raws li zoo raws li siv peroxides, yog metabolic enzymes. Txawm nyob rau hauv cov tshuaj tiv thaiv ntawm lipids peroxidation koom tshuaj rau lub cell daim nyias nyias lipid muaj pes tsawg leeg thiab arbitrary hloov nyob rau hauv raws li cov kev xav tau ntawm tus kab mob. Cov no muaj xws vitamin E thiab K, thyroxine (thyroid hormone), hydrocortisone, cortisone thiab aldosterone (tswv yim). Destabilizing cell phab ntsa hlau ions, vitamins C thiab D.
txhaum ntawm tus txheej txheem
Metabolic khoom ntawm lipid peroxidation yuav noog nyob rau hauv cov ntaub so ntswg thiab lub cev tshwj tsis yog tias antioxidant system tsis pov tseg ntawm lawv nrog rau cov tsim nyog tshaj tawm. Thiaj li cuam tshuam thauj ntawm ions nyob rau hauv lub cell daim nyias nyias, uas yog kov tej zaum yuav cuam tshuam lub ionic muaj pes tsawg leeg ntawm cov kua feem ntawm cov ntshav, tus nqi ntawm polarization thiab depolarization ntawm cov nqaij cell daim nyias nyias (tawg conduction ntawm paj impulses, lawv contractility, tom lub refractory lub sij hawm), pab txhawb lub nkag teb chaws ntawm cov kua rau hauv lub extracellular qhov chaw (edema, ntshav txhaws, ntsha tsis txaus). Nyob rau hauv tas li ntawd, cov khoom tseem ceeb ntawm lipid peroxidation, tom qab ib tug series ntawm biochemical kev tig cev, yog hloov dua siab tshiab rau aldehydes, ketones, acids thiab li ntawd. Cov tshuaj muaj ib tug tshuaj lom nyhuv ntawm lub cev, uas manifests nws tus kheej nyob rau hauv lub yuav txo tau tus nqi ntawm DNA synthesis, ua rau kom capillary permeability, ua rau kom oncotic siab, raws li thiaj li, sludge-syndrome.
Txoj kev ua nyob rau hauv lub tsev kho mob
Txij li thaum lub nce ntawm cov pa dawb radicals muaj puas tsuaj rau lub cell phab ntsa, thiab cov metabolic khoom cuam tshuam rau cov metabolism hauv thiab synthesis ntawm nucleic acids thiab tshuaj lom lub cev, lawv yog pathophysiologic ceeb nyob rau hauv txoj kev loj hlob ntawm ib tug xov tooj ntawm cov kev soj ntsuam tej yam kev mob. Lub luag hauj lwm ntawm lipid peroxidation nyob rau hauv daim siab yog ib qho tseem ceeb kab mob ntawm cov pob qij txha, cab kab mob, hemodynamic mob, oncological kab mob, traumas thiab kub yus. Pol yog ib tug ntawm cov yam tseem ceeb rau atherosclerosis. Dawb radicals oxidize cov roj cholesterol thiab nws tsis tshua muaj molecular yuag feem tsim khoom uas hais tias puas vascular phab ntsa. Qhov no pib ib tug cascade ntawm pathological tshua raug nyob rau kev puas tsuaj. Qhov no provokes ntshav txhaws, txuam nrog ntawm cov ntshav txhaws nyob rau hauv lub lumen ntawm me me hlab ntsha los yog txuas mus rau lawv cov phab ntsa. Raws li ib tug tshwm sim ntawm lub zog ntawm cov ntshav nyob rau hauv cov cheeb tsam no slows cia, raws li tau twb ua ib tug txog ntsha lumen. Qhov no muaj txhawb rau qhov ntxiv txuam nrog ntawm cov ntshav txhaws. Qhov tseem raug rau cov kev pauv nyob rau hauv lub coronary hlab ntsha, cov aorta, manifested nyob rau hauv lub tsev kho mob cov tsos mob ntawm coronary mob ntawm lub plawv.
tiv thaiv kev ntsuas
Practitioners yuav tsum nco ntsoov hais tias tus cwj pwm ntawm diagnostic thiab kho cov txheej txheem yuav qhib lub mechanism ntawm lipid peroxidation. Qhov no yuav tsum ceeb toom rau tus neeg mob. Los ntawm provoking yam xws li tawg txoj kev kho (ua rau mob cancer), ultraviolet lub teeb (nrog rickets, inflammatory kab mob ntawm lub sinuses, antibacterial kev kho mob chav), magnetic teb (MRI, CT, lub cev txoj kev kho) zaug nyob rau hauv ib tug hyperbaric chamber (nyob rau hauv poliomyelitis, altitude kev mob kev nkeeg).
Kev tiv thaiv thiab kev kho
Cov neeg ua hauj lwm nyob rau hauv rentgenkabinetom, orderlies thiab cov neeg tu mob, tshwj xeeb nyob rau hauv physiotherapy, mountaineers, cov neeg uas muaj ntau heev hnyav koj yuav tsum noj cov khoom noj uas muaj tej yam ntuj tso antioxidants: ntses, paj noob hlis los yog cov roj txiv roj, tshuaj ntsuab, qe, cov tshuaj yej ntsuab. Nyob rau hauv tas li ntawd mus hloov cov khoom noj, cov tshuaj yuav siv tau uas khi rau tej pab pawg los yog dawb radicals ke nrog co ntawm nce mus nce los valency. Yog li lawv sawv free ntawm active oxygen molecules, tiv thaiv lawv los ntawm losis tswvyim dabtsi rau lipid peroxidation amplifiers.
diagnostics
Thaum lub tam sim no theem ntawm kev loj hlob ntawm laboratory kev tshawb fawb peb muaj peev xwm mus ntes peroxide nyob rau hauv nyob tus yeees ntawm lom kua ntawm tus tib neeg lub cev. Ua li no, nqa tawm fluorescence microscopy. Cias muab, kom paub tias cov lipid peroxidation. Tus nqi ntawm no diagnostic kuaj xav tau kev pab tsis muaj kev tshab txhais txog. Tseeb, nyob rau hauv ib tug tseem ceeb npaum li cas raws li tus kab mob yog ntau yam kev ua si ntawm lipid peroxidation. Nov ntawm lub xeev no thiab txiav txim seb kev kho mob.
Los ntawm cov foundations hauv lub cev physiology ntawm lipid peroxidation yog tsim nyog rau cov tsim ntawm steroid cov tshuaj hormones, inflammatory kev sib kho, cytokines thiab thromboxanes. Tab sis thaum lub xov tooj ntawm tshuaj cov ntaub ntawv pauv cov khoom tshaj qhov pub tus nqi thiab peroxide kev puas tsuaj ntawm tes organelles, DNA thiab cuam tshuam rau synthesis ntawm cov nqaijrog, nyob rau hauv cov nyhuv nkag antioxidant system uas txo tus nqi ntawm cov dawb cov pa radicals thiab ions ntawm co kuj tsis paub meej valency. Nyob rau hauv tas li ntawd, nws yuav tsub kom lub synthesis ntawm catalase thiab peroxidase rau pov tseg ntau heev peroxides thiab cov khoom ntawm lawv ntxiv metabolism.