Khoom "Amikacin": xyuas ntawm cov kws kho mob

Yuav ua li cas puas xws li ib tug yeeb tshuaj raws li "Amikacin" (tshuaj)? Tswv yim rau cov hauj lwm zoo ntawm cov tshuaj hauv qab no. Cov tsab xov xwm kuj pib lub indications rau kev siv ntawm lub cuab tam, nws cov tshuaj nta thiab txoj kev siv.

Form, muaj pes tsawg leeg

Nyob rau hauv dab tsi daim ntawv no yog manufactured tshuaj "Amikacin"? Teb qhia hais tias qhov no neeg sawv cev yuav tsum tau muas raws li ib tug ntshiab, me ntsis dawb lias los yog tsis muaj kob tshuaj, uas yog tso dej raws leeg saib xyuas thiab intramuscular thawj coj.

Lub active caij ntawm amikacin formulation yog nyob rau hauv daim ntawv ntawm cov sulfate. Tsis tas li ntawd lub Cheebtsam ntawm cov tshuaj muaj xws li cov khoom xyaw xws li nta sulfuric acid, sodium bisulfite, dej d / u thiab sodium citrate d / u.

Nyob rau hauv lub muag khoom ntshai cov tshuaj los nyob rau hauv vials ua los ntawm lub khob, uas yog tau ntim rau hauv daim ntawv thawv.

Peb tsis tau hais tias cov tshuaj "Amikacin", xyuas uas muaj ntau tshaj li zoo, yuav muaj nyob rau hauv daim ntawv ntawm ib tug hmoov npaj rau tov rau kev txhaj tshuaj.

mechanism ntawm qhov kev txiav txim

Yuav ua li cas yog "Amikacin"? Xyuas ntawm cov kws kho mob hais tias ib tug semi-hluavtaws tshuaj tua kab mob tus neeg saib xyuas, uas belongs rau cov pab pawg neeg ntawm aminoglycosides thiab ua bactericidal.

Xam tias yog ib tug yeeb tshuaj mas active tiv thaiv kab-tsis zoo aerobic kab mob thiab tej yam Gram-zoo kab mob. Nws yuav tsum tau muab sau tseg hais tias nws muaj zoo stability co microorganisms.

Tshuaj "Amikacin" uas xyuas muaj peev xwm tawm tag nrho cov neeg mob, tsis plam txoj kev nyob rau hauv tus ntawm enzymes uas inactivate lwm aminoglycosides, thiab muaj peev xwm kuj adversely cuam tshuam lub hom ntawm Pseudomonas aeruginosa, uas muaj siab kuj mus gentamicin, tobramycin thiab netilmicin.

Kev tig tau muaj peev xwm tshuaj

ib tug kho "Amikacin" sucked? Xyuas tau qhia hais tias tom qab intramuscular thawj coj ntawm cov tshuaj yog absorbed kiag li thiab sai sai. Qhov nruab nrab kho concentration ntawm lub active tshuaj ntawm lub cuab tam khaws cia rau 11-12 teev.

"Amikacin" uake rau ntshav cov nqaijrog, nws yog zoo faib nyob rau hauv lub extracellular kua nyob rau hauv bronchial kua, zis, hnoos qeev, kua tsib, aqueous lom zem nrig txog kev pom nruab nrog cev, niam cov kua mis, thiab hlwb txha nqaj qaum kua.

Qhov no tshuaj yog tsis metabolized. Nws yog tas los ntawm ob lub raum nyob rau hauv unchanged daim ntawv.

Indications rau kev tswj hwm ntawm lub tshuaj

Nyob rau hauv tej rooj plaub, siv yeeb tshuaj siv "Amikacin" (tshuaj)? Cov me nyuam (cov tswv yim hais txog qhov cuab tam, tawm hauv ntau cov neeg mob) thiab cov neeg laus uas cov tshuaj yog tshuaj rau kab thiab inflammatory kab mob, uas yog tshwm sim los ntawm Gram-tsis zoo micro-kab los yog lawv koom haum ua teb:

• sepsis;
• kab mob ntawm cov pa ib ntsuj av tau;
• Cns kab mob (xws li meningitis);
• lub taub dej khawb endocarditis;
• mob plab kab noj hniav kab mob;
• kab mob (kua paug) daim tawv nqaij thiab nqaij mos;
• Mob txeeb zig (xws li cystitis, pyelonephritis, urethritis);
• biliary ib ntsuj av tau;
• qhov txhab kab mob;
• kab mob ntawm cov pob qij txha thiab cov pob txha;
• postoperative kab mob.

Bans cov kev taw qhia ntawm

Nyob rau hauv tej rooj plaub, koj muaj peev xwm tsis nkag mus rau hauv lub tshuaj "Amikacin"? Mob Ntsws Txheem Dej (xyuas ntawm cov tshuaj no muaj nyob hauv qab no), qhov no tshuaj khoom zoo heev. Txawm li cas los, tej zaum nws yuav siv tsis tau los yog thaum:

• cev xeeb tub;
• neuritis ntawm lub hnov paj ;
• mob loj heev mob raum tsis ua hauj lwm xws li uremia thiab azotemia;
• siab rhiab heev mus rau yeeb tshuaj tshuaj;
• siab rhiab heev rau lwm aminoglycosides.

Nrog kev saib xyuas lub tsev no yuav tsum tau siv nyob rau hauv cov me nyuam mos, lub cev qhuav dej, Parkinson tus kab mob thiab botulism, raum tsis ua hauj lwm, nyob rau hauv cov neeg laus cov neeg mob, nyob rau hauv lub neonatal lub sij hawm, thaum lub sij hawm lactation, thiab nyob rau hauv ntxov ntxov cov me nyuam mos.

Tshuaj "Amikacin": daim ntawv qhia

Xyuas tau tshaj tawm hais tias nws yuav zoo dua kho miv nyuas siv zug ntawm cov tshuaj nyob rau hauv lo lus nug yuav tsum tsuas yog siv nyob rau hauv kws kho mob lub kev txiav txim.

Cov tshuaj no yog muab intravenously los yog intramuscularly rau cov neeg laus thiab cov me nyuam los ntawm rau xyoo ntawm lub hnub nyoog.

Qhov siab tshaj plaws ntau npaum ntawm no tshuaj tua kab mob rau cov neeg laus yog 15 mg / kg ib hnub twg. Lub caij ntawm kev kho mob nyob rau hauv kev saib xyuas txhais tau tias thaum muab intravenously yog lub lim tiam, thiab intramuscular - 9-10 hnub.

Raws li hais cov me nyuam, cov thawj zaug ib koob tshuaj ntawm cov tshuaj rau lawv yog 10 mg / kg, thiab ces - 7.5 mg / kg txhua txhua 20-24 teev.

Tso dej raws leeg thawj coj, active tshuaj yuav tsum xub muab diluted nrog 5% dextrose los yog 0.9% sodium chloride tshuaj.

phiv

Thaum uas siv cov tshuaj "Amikacin" tej zaum yuav tshwm sim xws tshwm sim raws li xeev siab, nkees nkees, ntuav, mob taub hau, impaired siab muaj nuj nqi, anemia, ototoxicity, nephrotoxicity, daim tawv nqaij ua pob liab vog, mob ntawm kev txhaj tshuaj rau ntawm qhov chaw, khaus, dermatitis, daim tawv nqaij liab liab, phlebitis, ua npaws , periphlebitis, angioedema.

Xyuas

Xyuas tshwj xeeb hais txog cov kev tshuaj "Amikacin" cam hais tias nyob rau hauv feem ntau cov tshuaj proves zoo heev. Nws yog zoo mus sib ntaus sib tua tiv thaiv ntau yam kab mob thiab zoo heev tswj lub zog ntawm tus neeg mob. Txawm li cas los, nws yuav tsum tau muab sau tseg hais tias muaj ntau cov kws kho mob muaj kev txhawj xeeb hais tias pom tau hais tias cov tshuaj yuav ua rau muaj ntau yam tshwm sim. Nyob rau hauv no hais txog, feem ntau cov kws txawj ntshai muab cov tshuaj no thiab hloov nws nrog kev ruaj ntseg analogues.