Cov tshuaj "Tamsulosin": cov lus qhia rau kev siv, nqe, xyuas thiab analogues

"Tamsulosin" antidizuricescoe yog cov tshuaj txiav txim thiab yog siv raws li ib tug symptomatic urinary modulator txheej txheem nyob rau hauv urological kab mob tshwm sim los ntawm cell-phem prostate hlav cim. Cov tshuaj tiv thaiv mechanism yog qhia los ntawm ib tug gradual txo nyob rau hauv kev siv nyob rau hauv lub tiaj nqaij ntawm lub prostate, raws li zoo raws li lub so ntawm lub zais zis caj dab. Nyob rau hauv tas li ntawd, muaj ib tug xim thaiv cov hlab urethral alpha 1A-adrenretseptorov, uas ua rau minimization ntawm cov teebmeem cai rhuav txhua - ib tug natural txim ntawm txoj kev loj hlob ntawm adenomas.

Pharmacological nta ntawm "Tamsulosin"

Haum ntawm cov tshuaj active cov khoom xyaw rau hauv lub mob huam yuav ua tau mus rau 100%. Experimentally paub tseeb tias cov haum yog nce thaum peb noj lub tshuaj sai li sai tau tom qab ib tug noj mov. Lub degree ntawm assimilation proportional rau lub sij hawm tom qab txij li thaum tau ntawm cov tshuaj (i.e., muaj yog ib tug linear kinetics). Lub ncov concentration ntawm cov reactants nyob rau hauv cov ntshav yog attained tom qab rau lub sij hawm (ib koob tshuaj 400 mg). Txawm li cas los, qhov no lub sij hawm lub sij hawm tej zaum yuav txawv nyob ntawm seb muaj hnub nyoog ntawm tus neeg mob.

Nws yog muab sau tseg tias txais tos ntawm chav kawm ntawm tsib hnub, lub concentration ntawm lub Cheebtsam nyob rau hauv cov ntshav nce los ntawm 60-70%. Tamsulosin hydrochloride sufficiently maj mam nkag mus rau hauv metabolic dab: uptake nrog lub tsim ntawm ruaj metabolites uas muaj siab selectivity rau lub alpha 1A-adrenoceptor.

indications

Cov tshuaj "Tamsulosin" phau ntawv qhia dlhos li ib tug neeg sawv cev rau cov kev kho mob ntawm cov benign prostatic hyperplasia, mob symptomatic (adenoma, dysuria, thiab lwm yam sab qhov chaw mos huam kab mob).

Txij li thaum tus soj ntsuam kev tshawb fawb tsis tau qhia tej qho tseem ceeb tshua ntawm lwm yam ntawm hais tias kws pab pawg neeg, ces muaj yog tsis muaj kev txwv nyob rau hauv daim ntawv thov ntawm "tamsulosin" raws li ib tug pab catalyst nrog kev kho mob thaiv cov hlab xim alpha-1a adrenergic receptor.

Pom zoo npaum thiab tus qauv ntawm koom haum saib xyuas

Qhov uas tsis muaj hypotensive nyhuv - ib tug yam ntxwv feature ntawm cov tshuaj "Tamsulosin". Cov lus qhia rau kev siv hais tias cov kev xav tau kev koob xaiv ib leeg yog tsis - sufficiently lus muab 400 micrograms ntawm cov tshuaj tom qab noj tshais (2 tsiav tshuaj / ntsiav tshuaj uas 200 mg txhua, los yog 1 capsule / ntsiav tshuaj uas 400 mg). Ntxiv mus, qhov no txhua txhua hnub tus nqi yuav tsum tsis txhob yuav kho, txawm yog hais tias tus neeg mob tau cai me deviations nyob rau hauv lub raum lossis daim siab. Cuaj kaum, tus pib ntawm lub tshuaj kawg yuav tsum tau preceded los ntawm ib tug caij nyoog mob nyob rau hauv thiaj li yuav cais tau ntawm prostate cancer. Tsis tas li ntawd nyob rau tag nrho thaum lub sij hawm kev kho mob yuav tsum qhov quav xeem.

Tsiav tshuaj thiab cov ntsiav tshuaj "tamsulosin" yuav tsum tsis txhob zom - ua txhaum ntawm lub hnab ntawv tej zaum yuav cuam tshuam qhov kev tso tawm tus nqi ntawm lub active reagents. Tam sim ntawd tom qab noj cov tshuaj no yog pom zoo kom haus dej haus dej. Nws yog nruj me ntsis txwv tsis pub siv "Tamsulosin" nyob rau hauv lub supine txoj hauj lwm.

Uas twb muaj lawm cov kev txwv thiab contraindications

Cov tshuaj "Tamsulosin", tus nqi ntawm uas, nyob ntawm seb lub chaw tsim tshuaj paus thiab ntim tawm tswv yim, yog hom twg 400-1700 rubles, tsim heev dua lwm yam rau cov txiv neej. Yog li ntawd, kev tshawb fawb nyob rau hauv nws cov teebmeem rau lub fetus tsis tau ua thaum lub sij hawm cev xeeb tub. tsuas tshuaj yog muab rau cov ntsiav tshuaj cov ntaub ntawv, uas yog, qhov mob ntawm "benign prostatic hyperplasia" yuav tsum tau muab tso rau hauv lub daim ntawv ntsuam xyuas (nrog ib tug yuav tsum pre-test rau mob cancer).

Cov contra - meem kev txhawj xeeb mus rau lub "Tamsulosin" tshuaj (Neeg daim ntawv thov muaj ib tug ncauj lus kom ntxaws daim ntawv teev cov tag nrho cov koom haum pab reagents). Nws yog undesirable rau siv ntawm hais tias neeg sawv cev rau orthostatic hypotension thiab mob cov kab mob ntawm lub siab los yog ob lub raum (nyob rau hauv xws li mob, tus kws kho mob yuav tsum kwv yees lub peev xwm kev pab cuam ntawm kev siv "tamsulosin" thiab txiav txim seb cov twg tau tsis zoo los ntawm ib tug kho cov hoob kawm).

Nrog kev txais tos permissible teeb kiv taub hau, tej zaum hloov semiconscious lub xeev. Cov neeg tsav tsheb uas tsav tsheb thiab neeg ua hauj lwm, uas nws kev hauj lwm koom nrog ib tug kev hem thawj ntawm kev raug mob, yuav tsum soj ntsuam huab ceev faj nyob rau hauv txoj kev siv cov tshuaj yeeb dej caw.

phiv

Zoo li lwm yam kev siv yeeb tshuaj, muaj kev phiv thiab tshuaj "Tamsulosin" (tus nqi ntawm cov txiv neej noj qab haus huv yog high school, thiab kev tsis haum tshuaj yog menyuam yaus, yog li ntawd lub phiv tshuaj xam tau tias yog raws li ib tug tseem ceeb tsis muaj nws tsis yog tsim nyog).

Nyob rau hauv thaum uas tig mus nrog lub zoo cov nyhuv yuav muab qhov chaw:

• mob taub hau;
• voos ntawm cov tawv nqaij;
• ntev ntawm raws plab;
• mob arrhythmias;
• pelvic mob.

"Tamsulosin" Tej zaum, analogues ntawm uas yog lug muaj nyob rau ntawm lub lag luam, yuav ua insomnia cov neeg mob los yog, conversely, ntau tsaug zog. Nyob rau hauv tsawg zaus - ib ntus ua txhaum ntawm lub rooj zaum thiab lub weakening ntawm potency.

Overdose, nws tshwm sim thiab cov neutralization

Cov tsos mob ntawm overdose, uas tau ua ib tug txais ntawm txoj kev siv yeeb tshuaj yog "Tamsulosin" (cov lus qhia rau kev siv ceeb toom ntawm no), nws yuav qhia tau mob hypotension. Thiab txawm hais tias tus yuav ua rau muaj qhov no scenario yog tsis tshua muaj tsis tshua muaj, lub algorithm pab cuaj kaum ua:

• tam sim ntawd muab tus neeg mob ib tug kab rov tav txoj hauj lwm;
• Yog hais tias tsim nyog, nqa tawm ib tug complex ntawm kev ntsuas tsom ntawm lub normalization ntawm cov hlab plawv system ntawm lub cev;
• kom paub tseeb lub zog ntawm ob lub raum (lub kev twb kev txuas apparatus ntawm dag ntshav purification impractical vim hais tias cov active ingredient yog txig txuam nrog cov ntshav protein tebchaw);
• ua ntuav nyob rau hauv ib tug neeg mob nyob rau hauv kev txiav txim kom tsis txhob ntxiv haum ntawm reactants (kuj muaj tseeb pais plab lavage nrog thaum uas tig mus siv ntawm cov tshuaj ntaus cev);
• nyob rau hauv lub qhaj ntawv ntawm lub zog ntawm txoj kev txhim kho kom muab cov tshuaj uas kov cov ntshav ncig.

Tshuaj kev sib tshuam: qhov xwm ntawm lub tshua

"Warfarin" thiab "Diclofenac" qualitatively cuam tshuam cov qhov tso zis ceev ntawm lub cev "Tamsulosin" tshuaj (tshuaj nqi txiav txim siab, tab sis cov no nws muaj nqis). Txawm li cas los, heev pom txog tus txha siv cov tshuaj nyob rau hauv lub tsev kho mob yog tsis nqa tawm, raws li ib tug tsim nyog tau, huab ceev faj yog pom zoo. "Atenolol" thiab "Enalapril" tsis nrog hais tias cov ntaub ntawv uas, "cimetidine" txhawb concentration "tamsulosin" ntshav, thiab "Furosemide" muab lig opposite tshwm sim.

Cov txheej txheem ntawm tej ntshav siab provoked los ntawm tsawg ntawm cov medicament tej zaum yuav kho kom zoo vim lub txhawb kev siv ntawm lwm yam alpha-1A adrenoblokatorovv los yog diuretics thiab anesthetics. Tseem ceeb ntxim rau cov pharmacological kinetics ntawm free fractions "Diazepam" thiab "chlormadinone" los ntawm kev npaj "Tamsulosin" phau ntawv qhia (nqi saum toj no txhais tau tias -. 500-1400 tshiav) tsis txhais.

Cia tej yam kev mob thiab txee lub neej

Nyob rau hauv cia tej yam kev mob ntawm cov tshuaj "Tamsulosin" qhia hais hauv qab no:

• muaj kev nyab xeeb kub ntau - 15-25 degrees Celsius;
• optimum av noo - 70%.

Yuavtsum tau kawm uantej yog tus cia cov ntaub ntawv uas nyob rau hauv cov ntim (nyob rau hauv ib qhov chaw muab tsis cuag rau cov me nyuam, uas yog zoo muaj kev tiv thaiv los ntawm ncaj qha tshav ntuj).

Thaum uas tag nrho cov ntsiab lus qhia rau hauv lub chaw tsim tshuaj paus guarantees tias cov kho nyhuv "Tamsulosin" yuav tsis muaj zog nyob rau hauv lub ob lub xyoos txij li thaum nws tso tawm.

Drug analogues "Tamsulosin"

Daim ntawv teev cov "doubles" yog sawv cev los ntawm ob pab pawg ntawm cov tshuaj. Cov thawj pab pawg neeg no muaj xws li tshuaj, ntau, lub thib ob - ib tug tsawg pauv npe.

Pej xeem cov nyiaj:

• "Omnic" (nyob rau hauv tus thawj - Omnic), tsim kom muaj - lub Netherlands, qhov kev tso tawm daim ntawv - cov ntsiav tshuaj / tsiav tshuaj 10/30 daim ib pob, nqi ntau - 380-1700 rubles.
• "Proflosin" (Proflosin), lub teb chaws Yelemees, hlwv ntawm 30 tsiav tshuaj, cov nqi kwv yees li - 500 rubles.
• "Sonizin" (Sonizin), Lub teb chaws ntawm hauv paus chiv keeb - Romania, ib tug txheej txheem pob ntawm 10 los yog 30 tsiav tshuaj, qhov nruab nrab nqi - 450 rubles.

Lwm yam trademarks thiab pauv npe ntawm cov tshuaj "Tamsulosin" (analogs uas yog tsis tshua muaj heev los yog tso cov ntaub ntawv tau twb coj tawm ntawm ntau lawm):

• "Omsulozin" (Omsulosin), Is Nrias teb, tsiav tshuaj 0.4 mg (30 pcs.) Nqe yog hom twg los ntawm 350 mus 550 rubles.
• "Tamsulosin-Teva" (Tamsulosin-TEVA), "Tamar-Actavis" lub tuam txhab khoom, tim Nkij teb chaws, qhov zoo ntawm lub ntim thiab tus nqi yog tib yam li nyob rau hauv lub yav dhau los cov ntaub ntawv.
• "Tamsulosin-Retard" ( "understudy" pab tso tawm tivthaiv), cov ntau lawm kab tswm nyob rau hauv Russia, ntsiav tshuaj 400 mg, tus nqi - txog 300-360 rubles.

"Tamsulosin": xyuas ntawm cov kws kho mob thiab cov neeg mob

Kev kho mob kho nrog cov tshuaj no yog feem ntau muaj kev vam meej thiab yog qhia nyob rau hauv ib tug regression kab zauv xam qhovkev rau uas tsis yog-phem prostate hlav.

Tom qab hais txog 90 hnub ntawm cov tsos mob tau txo nyob rau hauv 2 lub sij hawm, nrog rau cov thawj hnov hloov twb cai nyob 14-21 hnub. Tomqab kawm tas cov tsos mob ntawm lub Performance index kev uas yuav ntog los ntawm 75% (nyob rau hauv kev sib piv nrog rau cov pib theem), uas yog yeej muaj ib qho tau tshwm sim.

Zoo nkauj tolerability "Tamsulosin" (daim ntawv qhia nqi thiab feem ntau generic tshuaj yuav muab saum toj no) yuav ua rau nws yooj yim heev siv thaum muab neeg mob rau kev kho mob. Txawm li cas los, mus cuag nyiaj pab ntau tshaj tej zaum nyhuv uas cov tshuaj yeeb dej caw yog tsis txaus, nws yog pom zoo kom hais tias txhawb txoj kev kho nrog rau lwm cov kev thiab cov kws tshuaj.