Cov tshuaj 'calcium pantothenate': tus yam ntxwv thiab siv nyob rau hauv cov tshuaj

Pantothenic acid (ntau npaum daim ntawv - lub tshuaj "Calcium pantothenate") muaj nyob rau hauv cov pab pawg neeg ntawm vitamin B. Qhov no oily, optically active kua, mas soluble nyob rau hauv dej, yog nkag cleaved nyob rau hauv qhov kev txiav txim ntawm tshav kub, acids thiab alkalis.

Pantothenic acid yog pom nyob rau hauv cov zaub mov thiab yog tsim los ntawm plab hnyuv microflora (Escherichia). Tom qab haum nws nkag mus rau hauv cov hlab ntsha thiab yog nqa rau tag nrho cov nruab nrog cev thiab cov nqaij, yog tso rau hauv lub siab, tej nyob rau hauv myocardium, raum thiab skeletal leeg. Nyob rau hauv lub cev, dua li acid txuam nrog cov nqaijrog thiab ib feem ntawm cov CoA (Coenzyme A). neej puas khoom ntawm cov tshuaj "calcium pantothenate" tas nyob hauv cov zis thiab feces. Nws yuav tsum tau hais tias tus xov tooj ntawm xaiv pantothenic acid yog ib txwm zoo tshaj qhov ntawd uas nkag mus rau hauv lub cev nrog cov zaub mov. Qhov no yog vim nws kab mob synthesis.

Pantothenic acid yog ib feem ntawm CoA, uas muaj peb qhov chaw: hauv lub residue tiolamina, pantothenic acid, 3-phospho-5adenozin-5-diphosphate. CoA yog ib qho tseem ceeb nyob rau hauv metabolism, koom nyob rau hauv lub hauj lwm ntawm lub Krebs voj voog nyob rau hauv lub lom synthesis thiab oxidation ntawm carbohydrates, lipids, glucosamine tsim, acetylcholine, hippuric acid, porphyrins, etc.

Tshuaj "Calcium pantothenate" - me ntsis yellowish los yog dawb hmoov nrog ib tug ntsim saj, ntxhiab, soluble nyob rau hauv cov dej. Aqueous lub ntsiab ntawm thermally ruaj khov, tab sis sai zom thaum raug acid thiab alkali. Cov kws npaj ua raws li cov ntsiav tshuaj, hmoov thiab cov kev daws nyob rau hauv vials.

Nws pharmacological kev ua kev npaj "Calcium pantothenate" qhia tau hais tias tom qab pantothenic acid transformed rau hauv Coenzyme A, uas muab beta-oxidation, fatty acid synthesis, oxidative decarboxylation, thiab hloov pyruvic acid thiab ketoglutaric acetyl. Nws yuav pab kom cov haum ntawm zib nyob rau hauv cov hnyuv, tsub kom txog qib ntawm glycogen nyob rau hauv lub siab, normalizes lub hormonal raws li txoj cai ntawm tus kab mob, tshwj xeeb tshaj yog thaum lub sij hawm cev xeeb tub.

Thaum tsis muaj peev xwm ntawm pantothenic acid nyob rau hauv lub cev yog inhibited hormone muaj nuj nqi pituitary, adrenal caj pas thiab txiav. Lub adrenal qog thiaj li cov theem ntawm steroid cov tshuaj hormones, uas muab pigmentation ntawm cov plaub hau thiab tej tawv nqaij. Metabolic teeb meem provokes dermatitis, daim tawv nqaij depigmentation. Sib hloov cai nyob rau hauv lub adrenal qog thiab tshee cov ntaub so ntswg. Lawv muaj peev xwm kuj yuav tawg lub cev muaj zog sib haum, paug raum tus kab mob, lub plawv, hnyuv thiab plab. Lub hom ua rau vitamin tsis yog tsis txaus cov nqi ntawm cov no vitamin nyob rau hauv cov zaub mov, plob tsis so tswj kab mob, thiab lub caij nyoog siv tshuaj tua kab mob (sulfonamides, tshuaj tua kab mob).

Lub ntsiab kev soj ntsuam tej yam tshwm sim ntawm ib tug tsis muaj pantothenic acid nyob rau hauv lub cev - kev nyuaj siab, qaug zog, qaug zog, insomnia, mob taub hau thiab mob mob, xeev siab, raws plab, kais ntawm daim tawv nqaij nres, duodenal rwj. Thaum tsis muaj peev xwm ntawm vitamin txo immunological kuj tau tus kab mob. Tiv thaiv no tom qab, ntau heev muaj ua pa kab mob.

heev feem ntau, cov kws kho mob muab cov tshuaj "calcium pantothenate" rau cov kev cai ntawm metabolic dab. Txais ntawm hais tias medicament polyneuritis, paresthesia, neuralgia, bronchitis, eczema, dermatitis, kub nyhiab, trophic ulcers, cev xeeb tub toxicosis, tuberculosis, hypothyroidism, pancreatitis, gastroduodenitis, etc. Tshuaj "calcium pantothenate" zoo-taus los ntawm lub cev. Rau enteral thawj coj yuav dyspeptic cov tsos mob, los ntawm parenteral (intramuscular txhaj) - hnov mob.

Oversupply ntawm calcium (hypercalcemia) yuav tshwm sim vim kawg ntawm lub endocrine qog (parathyroid caj pas). Hypercalcemia yog sau npe nyob rau hauv cov neeg laus. hypercalcemia Clinic yuav manifest li cov tsis muaj zog, tsis qab los noj mov, tej zaum cai tu-sauv thiab cem quav.