Cov tshuaj "Acyclovir-AKOS" (tshuaj). Cov lus qhia siv rau menyuam thiab cov neeg laus, xyuas

Hauv koob tshuaj dab tsi koj tau sau cov tshuaj "Acyclovir-Acos"? Cov lus qhia rau kev siv cov ntsiav tshuaj no yuav raug nthuav tawm hauv qab no. Tsis tas li ntawd, koj yuav pom tias qhov kev kho no yog siv rau, txawm tias nws muaj kev phiv thiab teeb meem, qhov no muaj nyob rau hauv nws cov lus uas nws sau tseg, thiab ua li cas ntim nws mus muag.

Muaj pes tsawg leeg, kev piav qhia, ntim ntawm lam tshuaj

Cov Acyclovir Acos zoo li cas (cov ntsiav tshuaj)? Cov lus qhia rau kev siv tau hais tias cov khoom noj muaj hauv cov tshuaj no yog acyclovir. Nws kuj muaj ntxiv cov khoom xyaw rau hauv daim ntawv ntawm talc, magnesium stearate thiab qos yaj ywm starch.

"Acyclovir-Acos" - cov ntsiav tshuaj (tus neeg mob xyuas yuav raug piav qhia hauv qab no) dawb-cylindrical dawb nrog ib qho kev pheej hmoo thiab lub ntsej muag. Hauv kev muag yeeb ntawm cov tshuaj tuaj hauv cov kab mob ntawm cov kab mob, uas yog muab tso rau hauv cov thawv ntawv. Tsis tas li ntawd, cov tshuaj no tuaj yeem pom hauv cov tsev txhab nyiaj uas tsaus nti.

Pharmacological thaj chaw ntawm medicinal khoom

"Acyclovir Acos" (ntsiav tshuaj) ua haujlwm li cas? Lus qhia rau kev siv hais tias qhov no antigipertic antiviral. Qhov no yog ib qho hluavtaws analogue ntawm purine nucleoside. Nws yog tau inhibit tus kab mob replication ntawm herpes simplex, cytomegalovirus, thiab Epstein-Barr virus thiab Varicella zoster.

Ntais ntawm cov tshuaj

Raws li cov kws kho mob tshwj xeeb, "Acyclovir-Agos", nws cov kev ntsuam xyuas pom zoo, qhia tau hais tias muaj kev nyab xeeb rau cov kab mob uas ua rau cov kab mob shingles thiab qoob.

Tom qab noj cov tshuaj nyob rau hauv cov hlwb mob, phosphorylation begins. Acyclovir yog hloov dua siab tshiab rau acyclovir monophosphate. Nyob rau hauv tus ntawm guanylate cyclase, lub tom kawg hloov mus rau hauv ib tug diphosphate, uas, nyob rau hauv lem, yog hloov dua siab tshiab rau triphosphate.

Qhov kev txuam xim ntawm cov tshuaj nyob rau kab mob, nrog rau nws cov co toxicity tsawg rau hauv lub cev, vim yog qhov tseeb tias nws cov khoom siv yam tsis sawv cev rau lub substrate rau lub enzyme thymidine kinase. Hauv qhov no, nws tsis yog tshuaj lom rau cov hlwb mammalian.

Tom qab qhov hloov ntawm acyclovir rau acyclovir triphosphate, nws inhibits cov synthesis ntawm DNA los ntawm tus kab mob 3 ntawm cov mechanisms:

• Hloov deoxyguanosine triphosphate;
• Yog tso rau hauv DNA saw, thiab tom qab ntawd nres nws cov elongation;
• Ua rau lub hlwb ntawm tus mob herpes simplex, ua rau lwm tus.

Raws li ib tug ntawm cov nyhuv no, kev luam ntawm tus kab mob no yuav tsis ua.

Kev ua haujlwm ntawm acyclovir kuj yog vim nws txuam rau hauv hlwb uas twb raug tus kab mob no lawm. Nrog rau herpes, cov tshuaj tiv thaiv kom tsis txhob muaj cov kab ua pob tshiab, thiab ua kom lub qhov txhab zoo kho, txo qhov mob thiab muaj ib qho kev tiv thaiv kab mob hauv immunostimulating.

Pharmacokinetic indices ntawm antiherpetic ntsiav tshuaj

Qhov twg yog qhov nqus ntawm cov tshuaj "Acyclovir-Acos"? Kev qhia rau kev siv cov ntawv qhia tias tom qab noj tshuaj, nws yog absorbed me me los ntawm txoj hnyuv. Nyob rau tib lub sij hawm, qhov ntau ntxiv (dose-dependent) yog tsim, uas yog txaus rau kev kho mob ntawm cov kab mob viral.

Cov zaub mov tsis muaj txiaj ntsim zoo rau qhov nqus ntawm cov khoom ua ub no. Raws li cov koob tshuaj tau ntau ntxiv, qhov bioavailability ntawm cov tshuaj yuav txo.

Qhov siab tshaj plaws concentration ntawm cov tshuaj tom qab nws qhov kev tswj hwm nyob rau hauv ib qho nyiaj ntawm 200 mg 5 zaug ib hnub yog 0.75 μg / ml, thiab qhov tsawg tshaj plaws concentration yog 0.45 μg / ml. Cov kev ntseeg no tau sau tseg tom qab ob xuab moos.

Nrog cov ntshav proteins, cov khoom nquag khi rau 10-35%. Nws nkag mus rau hauv cov ntshav thiab lub hlwb (lub ntsws, hlwb, lub hlwb, lub plab, cov hnyuv, kab mob, cov leeg nqaij, cov kua mis, kua mis, kua qaub, tus kabmob, amniotic kua, uterus, zais thiab mucous membrane Qhov chaw mos, thiab tseem nyob rau hauv cov ntsiab lus ntawm herpetic vesicles).

Cov tshuaj yog metabolized nyob rau hauv daim siab. Lub metabolite, hu ua 9-carboxymethoxymethyl guanine, yog tsim.

Yeeb tshuaj yog rho tawm los ntawm ob lub raum (62-91% ntawm koob) thiab los ntawm cov hnyuv. Tsis tas li ntawd, cov kab mob hauv cov kab mob yog txiav txim siab hauv cov pa tau los ntawm tus neeg mob.

Thaum noj tshuaj hauv nws lub neej ib nrab (hauv cov neeg laus) yog 3.4 teev, thiab hauv cov menyuam yaus (1-18 xyoo) - 2.4 teev. Yog li, nws muaj peev xwm yuav xyuam xim muab sau hais tias tus nqi ntawm kev ua qoob loo ntawm cov tshuaj txo qis nrog hnub nyoog.

Cov kev qhia rau kev siv tshuaj

Thaum twg lawv xaiv Acyclovir-Acos? Kev siv cov tshuaj no yog qhia rau kev tiv thaiv thiab kev kho mob ntawm cov kab mob uas yog tshwm sim los ntawm cov kab mob Varicella zos thiab Herpes simplex (2 thiab 1 hom). Yog li, cov tshuaj no zoo sib cav tiv thaiv:

• Yooj yim herpes ntawm daim tawv nqaij thiab mucous daim nyias nyias (rov ua dua thiab thawj);
• Shingles;
• Koj qhov chaw mos herpes (thawj zaug thiab rov qab);
• Herpes zos;
• Kab mob qoob (thawj hnub tom qab tsos mob pob liab liab).

Nws kuj tseem yuav tsum tau muab sau tseg tias cov tshuaj no yog cov kws kho mob tau siv rau cov neeg mob uas muaj kev tiv thaiv kabmob (piv txwv li, cov neeg muaj kab mob HIV, tom qab kev yug me nyuam thiab thaum txais tos cov tshuaj tiv thaiv kab mob).

Contraindications rau kev siv

Nyob rau hauv dab tsi mob yog nws txwv tsis pub thov "Acyclovir-Acos" (ntsiav tshuaj)? Qhov kev qhia qhia tau hais tias qhov kev tsis sib haum nram no:

• Cov menyuam yaus lub hnub nyoog (txog li peb xyoos);
• Hypersensitivity mus rau active khoom, raws li tau zoo raws li valaciclovir.

Nrog kev saib xyuas tshwj xeeb, cov tshuaj no yog tshuaj rau kev xeeb tub, lub raum tsis ua hauj lwm thiab lub cev qhuav, thiab thaum lub sijhawm pub niam mis.

Cov tshuaj "Acyclovir-Acos": yuav ua li cas coj tus neeg laus?

Ntsiav tshuaj yuav tsum tau noj ntawm ncauj, tsis hais txog khoom noj, nrog ib khob dej dawb.

Cov neeg laus rau kev kho mob ntawm herpes simplex nyob rau hauv lub xoos mucous thiab cov tawv nqaij xaiv 200 mg ntawm lub tshuaj tsib zaug ib hnub twg. Noj cov tshuaj txhua plaub teev (tsis xam pw tsaug zog).

Feem ntau, qhov ntev ntawm txoj kev kho nrog xws li ib txoj kev siv tshuaj yog tsib hnub. Tab sis yog tias tsim nyog, nws tuaj yeem raug ntev (raws li tus kws kho mob pom zoo).

Hauv kev kho ntawm cov neeg uas muaj kev tiv thaiv kab mob, kev noj tshuaj ib zaug xwb yuav nce mus rau 400 mg, thiab lub sijhawm kawm txog li 10 hnub lossis ntau dua.

Cov neeg laus cov neeg muaj mob herpes yog pom zoo kom siv 200 mg ntawm cov tshuaj li 5 zaug ntawm ib hnub (txhua 4 teev) rau 10 hnub (yog tias tsim nyog, kev kho mob ntxiv tau ntxiv). Kev kho yuav tsum tau pib ua sai li sai tau tom qab thawj cov cim kab mob ntawm tus kab mob. Yog tias muaj cov kev rov hlais rov qab, cov tshuaj no raug tshuaj nyob hauv lub sijhawm prodromal.

Txhawm rau tiv thaiv tus kab mob rov qab ua kom kis los ntawm tus kab mob herpes simplex, cov tshuaj tau sau rau 200 mg plaub zaug ib hnub (txhua 6 teev). Cov neeg uas muaj kev tiv thaiv zoo tuaj yeem siv cov tshuaj rau ntawm 400 mg ob zaug ib hnub (txhua 12 teev). Yog tias qhov kev tiv thaiv kabmob tsis txaus siab tau hais, qhov noj seem tseem zoo li qub, tabsis qhov nquag nce mus txog tsib zaug hauv ib hnub.

Txhua xyoo herpes rov hla (tsawg dua 6 zaus ntawm ib xyoo) yuav tsum tau kho qhov kev kho mob nram qab no: 200 mg tsib zaug ib hnub twg rau tsib hnub. Yog tias lub sijhawm ua rau ntau tshaj rau zaus hauv ib xyoos, ces tus neeg mob tau sau 400 mg ob zaug ib hnub rau 12 lub hlis. Lub sij hawm ntawm kev tiv thaiv yog feem ntau txiav txim siab los ntawm lub sij hawm ntawm lub sij hawm thaum muaj ib qho kev pheej hmoo ntawm tus kab mob.

Thaum kho nws tus mob herpes zos los yog tshem tawm tus neeg mob, 800 mg ntawm cov tshuaj tau sau tsib zaug ib hnub twg (txhua 4 teev) rau 7-10 hnub.

Qhov ntau tshaj ib koob tshuaj no yog 800 mg.

Cov tib neeg noj cov tshuaj txhaj loj tshaj plaws ntawm cov tshuaj yuav tsum tau txais ib qho dej loj.

"Acyclovir Acos" (ntsiav tshuaj): kev qhia ntawv rau cov me nyuam

Cov menyuam moslab uas nws muaj hnub nyoog tau 3 xyoos, cov tshuaj no yuav tsum tau qhia tsuas yog cov kws paub txog menyuam yaus. Feem ntau, cov tshuaj rau lawv zoo ib yam li cov neeg laus.

Kev kho kab mob qoob hlwv, cov me nyuam muaj hnub nyoog tshaj 6 xyoo tau muab 800 mg ntawm cov tshuaj plaub zaug ib hnub twg, thiab tus me nyuam muaj hnub nyoog 3-6 xyoos - 400 mg plaub zaug ib hnub. Yog xav paub ntxiv, cov kws kho mob siv cov qauv nram qab no: 20 mg ntawm ib tus me nyuam qhov hnyav. Noj tshuaj ntau tshaj 800 mg ntawm plaub zaug ib hnub twg raug txwv.

Lub sijhawm kho ntawm cov neeg mob me yog tsib hnub.

Cov neeg uas muaj kev tsis taus lub plab yuav tsum tau hloov cov tshuaj, nrog rau kev tso cai ntau zaus. Nws nyob ntawm seb hom kab mob thiab tus nqi ntawm creatinine clearance.

Cov kev mob tshwm sim tom qab noj tshuaj

Cov tshuaj "Acyclovir-Acos" tsis tshua muaj feem ua rau muaj kev phiv. Tab sis, raws li txoj kev qhia, lawv tseem muaj chaw rau.

1. Xeev siab, ua kom paub bilirubin, raws plab, mob plab, ntuav, rov qab tuaj yeem nce nyob rau theem ntawm daim siab ntawm daim siab enzymes.
2. Kev mob plob tsis ua hauj lwm, nce qib ntawm creatinine nyob rau hauv cov ntshav thiab urea.
3. Leukopenia, ntshav tsis txaus, thrombocytopenia.
4. Mob taub hau, kev hnov mob, kev puas siab ntsws ntshuam, kev xav tsis meej, kiv taub hau, tshaib plab, nkees, coma, convulsions.
5. Kev sib kis, kev mob plab, mob hnyuv, qhov ua kom thev taus, tus mob ua npaws, mob ua npaws, mob ua npaws, mob ntsws, mob ntsws, ua pa, ntxhov siab, tsis pom kev, ua mob hauv plab.
6. Pheej sai, alopecia.

Nws kuj tseem yuav tsum tau sau tseg tias nyob rau hauv cov neeg uas tau txais tshuaj antiretroviral, qhov ntxiv ntawm kev siv yeeb tshuaj "Acyclovir-Acos" tsis ua rau muaj kev cuam tshuam txog kev mob loj.

Cov tswv yim tshwj xeeb ntawm kev siv cov tshuaj antiherpetic

Kuv yuav tsum paub dab tsi ua ntej noj Acyclovir-Acos (tshuaj)? Cov kev qhia ntawv hais tias kev kho mob ntev los yog rov qab ua rau cov neeg uas tsis muaj zog lawm tuaj yeem ua rau muaj cov kab mob voos uas ua rau nws tsis txaus siab.

Cov kev tshawb fawb soj ntsuam kev nyab xeeb ntawm txoj kev siv cov tshuaj no thaum lub sijhawm cev xeeb tub tsis tau ua. Hauv qhov no, kev siv cov yeeb tshuaj "Acyclovir-Acos" tsuas yog tshwm sim rau cov xwm txheej thaum muaj txiaj ntsim los ntawm leej niam uas muaj txiaj ntsim zoo tshaj plaws rau tus me nyuam hauv plab.

Nyob rau hauv txoj kev kho mob nrog kev noj tshuaj hauv siab, tus neeg mob yuav tsum haus dej haus txaus.

Thaum pub niam mis, kev noj tshuaj tsuas yog sau rau cov mob hnyav thiab ib chav luv xwb. Qhov no yog vim qhov tseeb tias cov tshuaj yeeb tshuaj me me nkag mus rau hauv cov kua mis.

Cov tshuaj "Acyclovir-Acos" tsis tiv thaiv kev kis ntawm herpes los ntawm txoj kev sib deev. Yog li, thaum lub sij hawm kho mob, tus neeg mob yuav tsum tsis txhob sib deev.

Cov neeg mob cov lus hais txog cov tshuaj

Tam sim no koj paub tias yuav ua li cas thiab rau lub hom phiaj twg cov tshuaj "Acyclovir-Acos". Cov lus qhia rau kev siv cov cuab yeej no tau piav qhia hauv cov ncauj lus saum toj saud.

Raws li kev xyuas ntawm feem ntau cov neeg mob, cov tshuaj nyob rau hauv nqe lus nug zoo manifests nws tus kheej nyob rau hauv herpetic pob. Yog tias koj noj cov tshuaj ntsiav tam sim ntawd tom qab koj pom tus kab mob thawj zaug ntawm herpes, ces tus neeg mob rov qab los sai dua.

Nws kuj yuav tsum tau sau tseg tias "Acyclovir-Akos" ua tau zoo los kho cov kab mob shingles thiab nqaij qaib.

Ntxiv nrog rau txoj kev kho, cov tshuaj no feem ntau yog siv los ua tus neeg sawv cev tiv thaiv. Nws txoj kev txais tos pab kom txo tau cov xov tooj ntawm cov kev mob rov qab kom tsawg.

Nqe ntawm medicinal khoom

Nws kuj yuav tsum tau hais tias ntxiv nrog rau kev ua haujlwm siab, cov tshuaj "Acyclovir-Acos" pleases cov neeg mob thiab nws cov nqi pheej yig. Koj tuaj yeem muas 20 ntsiav tshuaj rau 30-40 Lavxias rub. Cov nyiaj no yog txaus rau txoj kev kho mob tag nrho.

Los ntawm txoj kev, analogues ntawm cov tshuaj no muaj nqis tsawg tsawg.