Indapamide - cov lus qhia rau kev siv

Indapamide "- ib qho yeeb tshuaj ntawm cov neeg thiazide zoo li lub diuretics, muaj ib qho kev ntxim rau antihypertensive. Kev kho mob "Indapamide" yog qhia rau kev siv thaum muaj kev kub ntxhov siab.

Pharmacotherapy ntawm yeeb tshuaj "Indapamide"

Cov kev qhia sau tseg tias cov khoom siv tshuaj ntawm cov yeeb tshuaj muaj feem xyuam nrog thiazide diuretics. Cov nyhuv ntawm cov tshuaj, muaj peev xwm xaiv ntawm blocking ntawm cov "calcium" uas yog qeeb, muaj txiaj ntsim rau qhov nce hauv lub tsho ntawm cov kab mob arterial, ua kom txo tau tag nrho peripheral vascular resistance.

"Indapamide" tsis hloov cov kabmob carbohydrate, uas yog siv rau cov neeg mob ntshav qab zib mellitus, thiab tseem tsis cuam tshuam rau qhov concentration ntawm lipids hauv plasma. Tablets "Indapamid" pab txo kev hypertrophy nyob rau sab laug lub plawv ntawm lub plawv, txo qhov kho siab ntawm cov kab mob vascular mus rau noradrenaline thiab angiotensin II, tsim kho cov synthesis ntawm prostaglandin E2, txo cov zus tau ntawm cov pa radicals. Feem ntau, ntawm 5 hnub-7th hnub ntawm kev kho mob, cov tshuaj yuav pom tias muaj cov tshuaj tua kab mob, uas pheej nrog ib koob ib zaug thoob plaws hnub.

Tshuaj "Indapamide" tshuaj

Cov kev qhia no hais tias cov tshuaj yog tus cwj pwm (bioavailability) (93%) thiab nqus tau hauv cov hnyuv. Qhov kev nqes dej yog qhov cuam tshuam los ntawm kev noj mov. Qhov loj tshaj plaws ntawm cov tshuaj nyob rau hauv cov ntshav yog tsim nyob rau hauv ib teev los yog ob tom qab noj cov tshuaj nyob rau hauv ib qho nyiaj ntawm 2.5 mg. Cov tshuaj metabolized los ntawm daim siab. 60% -80% ntawm cov khoom uas siv los ntawm ob lub raum nyob rau hauv daim ntawv ntawm metabolites, kwv yees li 20% - los ntawm cov hnyuv. Cov tshuaj muaj tsis muaj peev xwm.

Cov kev qhia siv "Indapamide"

Cov lus qhia no siv cov tshuaj siv los txo cov ntshav siab. Tsis tas li ntawd, cov tshuaj yog pom zoo rau cov neeg uas ri to lub plawv tsis ua hauj lwm.

Contraindications

"Indapamide" yog qhov tseem ceeb hauv:

- hypersensitivity rau nws thiab lwm derivatives ntawm sulfonamide pab pawg neeg,

- anuria,

- hypokalemia,

- cim kab mob ntsws los sis mob plab tsis zoo,

- lub sijhawm ntawm lactation,

- mob txoj hlab ntsws ntawm mob hlwb,

- cev xeeb tub,

- muaj hnub nyoog 18 xyoo (vim yog tsis paub),

- simultaneous siv cov tshuaj uas ua rau lub sij hawm QT ntxiv.

Nrog ceeb toom xaiv cov tshuaj no nyob rau hauv qhov muaj cov kab mob gout thiab diabetes nyob rau hauv qhov decompensation stage.

Txoj kev ntawm daim ntawv thov thiab kev siv tshuaj ntau npaum li cas "Indapamide"

Qhov kev qhia no pom zoo kom noj cov ntsiav tshuaj sab hauv tsis pub noj mis. 2.5 mg (txhua hnub txhaj tshuaj) yog zoo dua los siv thaum sawv ntxov los yog tav su. Nyob rau hauv rooj plaub thaum lub caij 1-2-lub hlis ntawm txoj kev kho mob nrog ib lub tshuaj tsis tuaj yeem cuam tshuam cov kev kho mob, qhov nce ntawm qhov txhaj tshuaj tsis raug pom zoo vim muaj kev pheej hmoo ntawm kev phiv. Nyob rau hauv cov ntaub ntawv no, ib tug ntxiv antihypertensive tus neeg sawv cev, uas tsis yog ib tug diuretic, yuav tsum tau ntxiv rau lub tswvyim ntawm kev kho mob siab ntawm kub siab. Thaum kho ob lub tshuaj antihypertensive, lub koob tshuaj "Indapamide" tseem zoo li qub.

Overdose

Cov tsos mob ntawm overdose manifest tsis muaj zog, ua txhaum ntawm lub functions ntawm gastrointestinal ib ntsuj av, xeev siab, ntuav, dej-electrolyte mob. Qee zaum, ib qho kev nyuab siab dhau ntawm kev nyuab siab thiab txo qis ntshav siab yuav tshwm sim. Nyob rau hauv cov neeg mob uas mob npuas paug ntawm lub siab muaj peev xwm tshwm sim hepatic coma.

Yog tias muaj ntau dhau lawm, nws yuav tsum tau ua kom tiav ib qho kev txhim kho kom haum rau cov dej-electrolyte balance: gastric lavage thiab symptomatic therapy.

Kev sib tham

Txhim kho cov txiaj ntsim ntawm lwm cov tshuaj kom muaj zog ntxiv ntshav. Nws tsis pom zoo los ua ke nrog kev npaj muaj lithium, vinamine, potassium-release diuretics.

Cov kev mob tshwm sim ntawm yeeb tshuaj "Indapamide"

Zoo li, zoo li hauv qee zaum dhau ntawm overdose. Ua yuam kev ntawm lub plawv atherosclerosis vim qhov poob ntawm potassium. Tsis tas li ntawd, cov kev mob tshwm sim tuaj yeem tshwm sim tsis zoo, txo qis hauv siab thaum sim sawv ntsug, xeev siab, mob plab, raws plab, qaug dab peg, tsis haum tshuaj. Nyob rau hauv qee zaum, tej zaum yuav muaj kev ntxiv dag zog ntawm gout, convulsions.