Benzathine benzylpenicillin: hauj lwm, lub zog thiab daim ntawv thov, analogs

Benzathine Benzylpenicillin yog ib tug tshuaj tua kab mob thiab belongs rau lub penicillin pab pawg neeg. Siv los kho tag nrho cov hom ntawm kis kab mob tshwm sim los ntawm cov kab mob raug rau qhov kev txiav txim. Nyob rau hauv no tsab xov xwm peb yuav teem tawm nyob rau hauv kom meej cov lus qhia rau kev siv, indications thiab contraindications mus rau yeeb tshuaj, raws li zoo raws li daim ntawv teev ib tug ob peb tus phooj ywg.

Benzathine benzylpenicillin: piav qhia ntawm cov tshuaj

Qhov no tshuaj yog ib tug ntawm thawj pab pawg neeg ntawm penicillin tshuaj tua kab mob. Dua li ntawm qhov ntev heev lub sij hawm daim ntawv thov, nws tsis tau poob nws qhov tseeb vim rau ntau yam kev ua thiab muaj peev xwm mus tua tau ib tug ntau yam ntawm pathogenic cov kab mob. Cov tshuaj, piv txwv li, yuav tiv nrog anthrax, meningococci, syphilis thiab ib tug plurality ntawm streptococci thiab staphylococci. Twb txhaj raws li nyob rau hauv cov hnyuv yog tsis absorbed benzathine benzylpenicillin.

Daim ntawv qhia nyob rau hauv Latin yog feem ntau cov kws kho qhov kws kho mob, thiab ces tus neeg mob yog yooj yim to taub dab tsi nws tau muab. Kom tsis txhob no tsis meej pem, koj cia li yuav tsum tau paub lub npe ntawm cov tshuaj nyob rau hauv cov lus no - Benzathine benzylpenicillinum.

Feem ntau, cov tshuaj yog muab intravenously los yog intramuscularly. Tab sis nws yog ua tau thiab tshuaj tus me nyuam mus rau hauv lub cev los ntawm cov leeg nrob kwj dej, subcutaneously los yog los ntawm lub cheeb tsam cov.

Benzylpenicillin - tshuaj tua kab mob muaj li ntawm cov tib yam kom nquag plias substance. Tab sis nws nkag mus rau hauv lub tshuaj nyob rau hauv daim ntawv ntawm cov ntsev. Yog li ntawd, yam khoom uas yuav tsum khaws cia rau ib ntev lub sij hawm tsis muaj txhawm cia. Thiab tom qab cov kev taw qhia ntawm penicillin G yog tso tawm los ntawm lub cev ntawm ntsev thiab pib nws antibacterial kev txiav txim.

Nyob rau qhov kev txiav txim nyob rau hauv uas lub ntsev yog ib tug active tshuaj, ntau ntau hom ntawm cov tshuaj. Dua li no, tag nrho lawv muaj roughly cov nyhuv tib yam, thiab ntau hom ntawv thiab qhov ntev ntawm cov nyhuv.

zaj lus tim khawv

Benzathine benzylpenicillin yog kws kho rau cov nram qab no cov kab mob:

• Cov kab mob ntawm cov pa kabmob (pleurisy, mob ntsws, bronchitis, empyema , thiab li ntawd.).
• Kab mob ntawm cov genitourinary system (syphilis, gonorrhea, urethritis, cystitis, adnexitis, salpingitis).
• Cov kab mob ntawm Upper pa ib ntsuj av tau (scarlet fever, tonsillitis, sinusitis, otitis media, sinusitis, laryngitis, etc.).
• Purulent kab mob ntawm lub nrig txog kev pom cov kabmob, cov pob txha thiab tej tawv nqaij, txheej week (ophthalmia, dacryocystitis, blepharitis, osteomyelitis, mediastinitis, erysipelas, cellulitis, qhov txhab kab mob, thiab li ntawd.).
• Hlwb rwj.
• Purulent meningitis.
• Septicemia, sepsis.
• Mob caj dab.
• Peritonitis.
• Cov kab mob tshwm sim los ntawm spirochetes (yaws, anthrax, etc.).
• Npaws tshwm sim los ntawm nas tom.
• Cov kab mob tshwm sim los ntawm Listeria, Clostridium, Pasteurella.

Tsis tas li ntawd, cov tshuaj yog muab nyob rau hauv prophylactically postoperative teeb meem thiab teeb meem nrog streptococcal kab mob (endocarditis, rheumatic fever, glomerulonephritis thiab thiaj li nyob.).

tshuaj

Benzathine benzylpenicillin (Latin Benzathine benzylpenicillinum) sai li sai tau tom qab thawj coj pib tawg ua me me, tso lub active tshuaj. Nyob rau tib lub sij hawm cov tshuaj nyob rau hauv cov ntshav rau tom ntej no 3 lub lis piam tom qab txhaj tshuaj. Cov kua tshuaj penetrates zoo npaum li cas tshaj nyob rau hauv cov ntaub so ntswg. Nws yuav tsum tau borne nyob rau hauv lub siab hais tias benzyl penicillin yog tau kov yeej lub placental barrier thiab tshwm sim nyob rau hauv cov mis nyuj ntawm niam. Tas los ntawm ob lub raum nyob rau hauv unchanged daim ntawv. Thaum lub sij hawm ua ntej 8 hnub tso hais txog 33% ntawm cov muab koob tshuaj.

Cev xeeb tub thiab pub niam mis

Raws li sau tseg saum toj no, cov tshuaj yog tau txeem lub tsho me nyuam thiab nkag mus rau hauv niam cov kua mis. Yog li ntawd, kev pub niam mis yuav tsum tau txiav thaum muab cov tshuaj.

Thaum lub sij hawm cev xeeb tub, lub sij hawm ntawm cov tshuaj yog tau tsuas yog tias cov kev pab rau cov poj niam yog ntau tshaj qhov txaus ntshai rau tus me nyuam. Qhov kev txiav txim yuav tsum tau ua los ntawm ib tug kws kho mob, cov lus ceeb toom yav tom ntej leej niam hais txog tag nrho cov tau zoo.

Contraindications

Benzathine benzylpenicillin (daim ntawv qhia tej zaum yuav muab ib tug kws kho mob) muaj ib tug xov tooj ntawm contraindications. Nws yuav tsum tsis txhob muab rau cov neeg uas muaj nram qab no mob:

• Intolerance rau penicillin los yog cephalosporin, ib tug tsis haum cov tshuaj tiv thaiv rau lawv.
• Cov theem siab ntawm poov tshuaj nyob rau hauv cov ntshav (hyperkalaemia).
• Arrhythmia.
• Nyab ua npaws.
• Bronchial hawb pob.
• Raum insufficiency.
• Pseudomembranous mob plab.

Ceev faj medicament los siv rau cov me nyuam mus txog rau lub hlis thiab prematurely.

phiv

Benzathine benzylpenicillin yuav ua rau ib txhia undesirable los, sau lawv hauv qab no.

Ntau yam kev tsis haum tshuaj:

• kub taub hau;
• ua xua;
• cov pob liab liab rau hauv txheej week thiab daim tawv nqaij;
• mob tej pob txha;
• eosinophilia;
• erythema multiforme;
• Angioedema;
• exfoliative dermatitis;
• anaphylactic poob siab.

Phiv tshua ntawm cov hlab plawv system:

• thrombocytopenia;
• anemia;
• coagulation mob;
• leukopenia.

Nyob rau hauv tas li ntawd:

• stomatitis;
• mob taub hau;
• glossitis;
• mob nyob rau hauv lub cheeb tsam ntawm cov thawj coj
• paug;
• infiltrates;
• jade peripheral;
• fistulas.

Nrog heev siv cov teeb meem fungi thiab micro-kab muaj peev xwm tsim kuj, ces cov tshuaj yuav poob nws cov hauj lwm zoo.

Benzathine benzylpenicillin: cov lus qhia rau kev siv

Cov neeg mob laus tshaj 12 xyoo, cov tshuaj raws li ib tug tiv thaiv kev ntsuas thiab kev kho mob ntawm cov kab mob kis yog tsim los siv ib zaug ib lub lim tiam rau ib lub tshuaj ntawm 300 mus 600 txhiab. Chav los yog ob zaug ib lub hlis ntawm 1.2 lab units.

Raws li kev tiv thaiv rau rheumatism prick tshuaj rau 6 lub lis piam, ib zaug ib lub lim tiam rau 600 txhiab units. Nyob rau tib lub sij hawm muab cov tshuaj aspirin los yog lwm yam narcotics yuav muab.

Cov neeg mob muaj hnub nyoog yau tshaj 12 xyoo, cov tshuaj yog muab ib zaug ib lub lim tiam ntawm lub nqi ntawm 5-10 txhiab. Chav ib 1 kg.

Ntawm tshuaj yuav tsum muab qhov chaw tsawg kawg yog 8 hnub. Qhov nruab nrab ntau npaum ntawm 2.3 lab units.

Ua ntej siv, cov tshuaj twb yaj nyob rau hauv saline, dej rau txhaj ad hoc los yog novocaine (2.5% los yog 5%).

Tswvcuab cov tshuaj tej zaum yuav nyob rau hauv lub nram qab no:

• intramuscular;
• tso dej;
• subcutaneous;
• Lumbar (ntawm cov leeg nrob kwj dej);
• pleural (los ntawm cov pulmonary pleura);
• subconjunctival (ntawm lub ocular ntaub so ntswg);
• nrog kua los ntawm lub pob ntseg;
• nrog kua los ntawm lub qhov ntswg;
• ncaj qha rau cov hloov khoom nruab nrog cov ntaub so ntswg.

Thaum lawv tseem nrog lwm yam tshuaj

Benzathine benzylpenicillin (qhia ncaj qha raws li qhia) tej zaum yuav koom tau nrog lwm cov tshuaj. Yog li nws benzylpenicillin yuav muaj cov nram qab cov kauj ruam: ib synergistic, antagonistic thiab bacteriostatic.

Nyob rau hauv tas li ntawd, cov tshuaj yuav tsub cov hauj lwm zoo ntawm cov tshuaj, teej tug mus rau indirect anticoagulants. Thiab thiaj li muaj cov hauj lwm zoo ntawm ethinyl estradiol thiab ntau yam qhov ncauj contraceptives.

Siv ua ke nrog narcotics yuav muab, allopurinol, diuretics tau nyob rau hauv txo tubular secretion thiab muaj zog ntau ntawm active ingredient. Nyob rau hauv tas li ntawd, allopurinol heev tsub kom kev pheej hmoo ntawm kev tsis haum tshuaj loj.

precautionary ntsuas

Tas ua ntej thawj txhaj tshuaj yog tsim nyog los aspirate. Yog hais tias cov tshuaj ntawd tau txais mus rau hauv cov hlab ntsha, tej zaum nws yuav ua rau ischemia los yog embolism. Nyob rau hauv tas li ntawd, tej zaum yuav muaj ib tug kev xav ntawm kev ntxhov siab vim, kev nyuaj siab, nraum qhov muag plooj tsis pom kev.

Nyob rau hauv tus neeg mob qhov twg koj yuav tau ua ob tug tshuaj ntawm ib lub sij hawm, cov tshuaj yog muab nyob rau hauv txawv caj npab los yog pob tw.

Thaum tus thawj ces tsis haum txoj kev kho yuav tsum tau tu ncua tam sim ntawd. Raws li tej yam tus kws kho mob yuav muab tshuaj rau tsis haum tshuaj tshuaj.

Feem ntau nrog benzylpenicillin taw "Levorinum" los yog "Nystatin", raws li muaj txoj kev pheej hmoo ntawm fungal kab mob. Nws yog yog li ntawd ntev-lub sij hawm kev kho yeeb tshuaj tej zaum yuav tshwm sim inhibition ntawm plab hnyuv microflora uas generates vitamins B. Nyob rau hauv no hais txog, yuav muab rau intramuscular thawj coj ntawm cov vitamins.

ceev faj

Benzathine benzylpenicillin muab nrog ceev faj nyob rau hauv cov neeg mob uas tau pom ib tug ntau yam ntawm lub raum muaj nuj nqi, muaj yog ib tug predisposition mus tsis haum ces, muaj kev mloog tau tus active ingredient. Cov txiav txim zaum kawg yeej ib txwm rests nrog tus kws kho mob, uas yuav tsum tau paub lub keeb kwm ntawm nws tus neeg mob.

Tsis pom zoo tshuaj rau cov kev kho mob ntawm neurosyphilis, txij li thaum tus kab mob no yuav tsis tau tiav rau yam concentration ntawm active tshuaj nyob rau hauv tus neeg mob cov ntshav.

analogs

Muaj lwm yam tshuaj uas muaj cov nyhuv tib li benzathine benzylpenicillin. Analogs, ntawm chav kawm, kuj zwm rau lub penicillin pab pawg neeg. Peb sau nto moo tshaj plaws thiab zoo:

• "Gramoks-D" - yog ua nyob rau hauv daim ntawv ntawm ib tug hmoov npaj rau yug me nyuam thiab lub qhov ncauj thawj coj.
• "Amosin" - yog ua nyob rau hauv tsiav tshuaj, ntsiav tshuaj thiab hmoov rau qhov ncauj thawj coj.
• "Smallpox" - yog ua nyob rau hauv daim ntawv ntawm cov phoov.
• "Hikontsil" - muaj nyob rau hauv daim ntawv ntawm cov hmoov thiab tsiav tshuaj rau qhov ncauj thawj coj.
• Azlocillin sodium ntsev - hmoov tshuaj uas ua rau ib cov tshuaj tso dej raws leeg txhaj tshuaj.
• "Ampicillin" - yog muaj nyob rau hauv cov ntsiav tshuaj, tsiav tshuaj, granules, qhov tseeb ua ib tug slurry, thiab yog coj hais lus.
• "Ekobol" - ua ntsiav tshuaj.
• "Ospamoks" - yog ua nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj, tsiav tshuaj thiab hmoov rau qhov ncauj thawj coj.
• "Phenoxymethylpenicillin" - yog muaj nyob rau hauv cov ntsiav tshuaj, dragees, granules thiab cov hmoov.
• "Star-Pen" - yog ua nyob rau hauv daim ntawv ntawm granules, uas yog diluted thiab coj lus.
• "Oxacillin" - yog ua nyob rau hauv daim ntawv ntawm cov ntsiav tshuaj, tsiav tshuaj, ib cov hmoov, los ntawm uas, ib tug tov rau kev txhaj tshuaj.
• "Standatsillin" - yog muaj nyob rau hauv tsiav tshuaj.
• Carbenicillin disodium ntsev - yog ua nyob rau hauv cov hmoov daim ntawv no rau qhov siv thiab ua txhaj tshuaj.

Yog li, txawm cov kuj ntev-lub sij hawm kev siv ntawm cov tshuaj nyob rau hauv cov tshuaj, nws tseem nyob ib tug ntawm qhov zoo tshaj cov neeg ua hauj tiv thaiv ib tug ntau yam ntawm tus kab mob.