Analogue "vilprafen" - yog hais tias nws yog leejtwg?

Cov ntawv pov thawj txawm noj tshuaj thiab tshuaj "Vilprafen" yog lub npe hu ua ib tug tshuaj tua kab mob teej tug mus rau lub pharmacological pab pawg neeg ntawm macrolides, lincosamides thiab streptogramin. Nws yog feem ntau kws kho rau combating kab mob kab mob, uas yog tshwm sim los ntawm raug microorganisms. Cai los ntawm cov tshuaj zoo nyob rau hauv tus neeg mob ua pa zig thiab kho hniav thiab qhov txhab ntawm lub urogenital system thiab dermal kab mob ntawm nqaij mos mos thiab ntaub so ntswg thiab ureaplasmosis gonorrhea, chlamydia thiab syphilis mikroplazmoze thiab zoo sib xws kab mob. Analogue "Vilprafen" - kev npaj "clarithromycin" - yog tsuas yog siv raws li ib tug lwm txoj.

pharmacological los

Vilprafen los yog nyob rau hauv lwm yam lus - Josamycin muaj siab ua si tiv thaiv intracellular kab mob, tab sis nrog rau qhov tshwm sim ntawm erythromycin kuj yog tsis yuam. High tshuaj concentration nyob rau hauv cov ntaub so ntswg txhab muaj ib tug meej bactericidal kev txiav txim ntawm enterobacteria thiab muaj me ntsis cov nyhuv. Qhov no txhais tau tias lub plab tsis hloov lub natural kab mob muaj.

kinetics txais tos

Noj kiag li tsis tiv thaiv kom txhob lub bioavailability ntawm lub zog ntawm cov tshuaj. vim hais tias nws yog absorbed yooj yim thiab fleeting los ntawm tus mob huam mus rau hauv lub hlab ntsha. Twb ib ob peb teev tom qab haus ntawm cov tshuaj "Vilprafen" nyiaj pab ntau tshaj cov ntshiab concentration yog tiav. Ntshav cov nqaijrog khi rau molecules dzhosamitsina, lub ntsiab active khoom sib ua zaub mov ntawm cov tshuaj, thiab nws cov concentration nce mus txog 15%. Tshwj xeeb tshaj yog feem pua cai nyob rau hauv lub tonsils thiab mob ntsws, hnoos qeev, lacrimal kua. Cov tshuaj yuav noog nyob rau hauv cov pob txha, cov nqaij thiab secreted nyob rau hauv niam cov kua mis tom qab dhau los ntawm lub placental barrier. Metabolism hauv dzhosamitsina rau weakly active metabolites nyob rau hauv lub siab. Qhov xaus los ntawm lub bile. Feem ntawm lub qhov zis yog hais txog 20%.

Dzhosamitsin - lub ntsiab tivthaiv ntawm cov tshuaj "Vilprafen"

Nws yog qhov tseeb hais tias Dzhosamitsin yog tib tug tseem ceeb tshaj plaws tshuaj nyob rau hauv nyob tus yeees ntawm cov tshuaj, ib tug analog ntawm "vilprafen" tsis muaj nyob.

Qhov loj tshaj plaws uas bothers neeg thaum yuav vilprafen - nws yog heev ib qho kim kev kho mob uas kav ntev tshaj li 10 hnub. Dhau nws nyob rau hauv thiaj li yuav ua tau ib tug zoo ntxim yuav tsum tau siab thiab coj yus kev noj tshuaj txhua txhua hnub. "Vilprafen" nrog tag nrho cov zoo xyuas txog cov tshuaj muaj ib tug high txaus nqe, kom cov neeg tas li tab tom nrhiav rau ib tug pheej yig thiab muaj tib yam li ib tug piv txwv. Ib txhia kws txawj pom zoo raws li ib tug analog "vilprafen" siv yeeb tshuaj "clarithromycin", tab sis tsuas yog raws li ib tug lwm txoj.

Nrhiav analogue "vilprafen" ntau ntau tsiv uas nws siv tsis yog txwv tsis pub rau cev xeeb tub cov poj niam, nws muaj peev xwm yuav siv tau los pub niam mis niam, thiab nws muaj kev ruaj ntseg rau cov me nyuam yaus. Nrog rau cov paub tsis tuaj kawm ntawv ntawm embryotoxic los "Vilprafen" cov tshuaj yog tshuaj, tsuas yog ua tib zoo soj ntsuam cov kev txaus ntshai thiab cov kev pab ntawm kev kho mob.

Tshuaj "Vilprafen" thiab nws cov nrog haus dej haus cawv

Cov kev cai annexed mus rau yeeb tshuaj, tsis muaj tej yam hais txog ntawm cov cawv thiab tshuaj yeeb dej caw active sis dzhosamitsina. Tshuaj "Vilprafen" thiab haus dej haus cawv - li thaum lawv tseem. Paub tab paub xav tus neeg yuav tsum tsis txhob hnov qab hais tias haus dej haus cawv yog ib txwm pheev ib phiv ntxim rau cov siab - lub ntsiab txoj cai lub luag hauj lwm rau lub feem ntawm cov tshuaj los ntawm lub cev. Nws yog xav hais tias mob loj heev kev ua txhaum ntawm daim siab kev ua yuav ua rau ib qho txawv txav khiav ntawm cov kua tsib thiab haus dej haus cawv kom tsawg yog tsis tshua muaj undesirable. Nyiaj pub them rau txhua hnub tus nqi yuav mus txog tsuas yog hais tias 200 milligrams ntawm dej cawv thiab hais tias nyob rau hauv lub qhaj ntawv uas muaj zog siab enzymes nyob rau hauv ntshav.