Phospholipid: nws yog dab tsi, yog vim li cas koj xav tau lub cev, dab tsi yog qhov mob pathology

Cov tib neeg lub cev - yog ib tug complex system, qhov twg txhua leej txhua tus, txawm lub me tshaj lub caij, muab nws tus kheej lub luag hauj lwm. Nyob rau hauv Feem ntau, lawv tag nrho cov ua hauj lwm thiaj li mus xyuas kom meej lub cev nruab nrog cev thiab ib tug ntev lub neej. Tab sis tej zaum muaj tsi xam pom tuag tsawg feempua sibtsoo, thiab ib co ntsiab ntawm lub cev pib rhuav tshem cov lwm yam, li no endangering tib neeg noj qab haus huv thiab lub neej. Tshuaj rau phospholipids - ib tug tiag tiag li piv txwv.

Yog vim li cas phospholipids

Cov tib neeg lub cev yog tsim los ntawm cov hlwb, uas yog ib txwm tam sim no nyias nyias phospholipids.
Cov lug yog muab kev koom tes nyob rau hauv lub tsheb thauj mus los ntawm roj thiab roj uas txhaws taus, yog kuab tshuaj ntawm hydrophobic tshuaj. Phospholipid - yog dab tsi? Los ntawm qhov seem yus pom ntawm cov organic Science News for KIDS nws yog ib tug complex mix ntawm esters ntawm polyhydric alcohols thiab fatty acids muaj nyob rau hauv lub molecule raws li ib tug phosphoric acid residue. Figuratively nyob rau hauv lawv yog tus Tsov tus tw-hydrophobe, sim kom tsis txhob kov cov dej, thiab lub taub hau-hydrophile txig nyob rau hauv kev sib cuag nrog dej. Amphiphilicity Qhov no yog ib tug tseem ceeb feature, txiav txim yog vim li cas lub cev tseem ceeb heev rau txhua tus phospholipid. Ua li cas nws txhais li cas? Firstly, cov tshuaj yog yaj cholesterol thaum tswj cov ductility ntawm cell week, thiab "kho" lawv nyob rau hauv cov kev tshwm sim ntawm deformation. Ob, kev cuam tshuam rau cov ntshav coagulation, ntaub so ntswg lwm. Nrog ib tug tshaj ntawm phospholipids puas hlwb tsis tau rov qab, ua rau ib tug ntau yam ntawm cov kab mob. Raws li lawv xwb, cov tshuaj no yog zoo, tsis zoo thiab nruab nrab.

antiphospholipid syndrome

Tus kab mob no tshwm sim thaum lawv pib tsim tshuaj rau phospholipids. Xws li ib tug mob hu ua antiphospholipid syndrome (APS). Yog vim li cas:

- kis kab mob;

- sab nyhuv ntawm psychotropic tshuaj thiab hormonal pov;

- periarteritis nodosa ;

- qog nqaij hlav;

- lupus erythematosus;

- AIDS;

- ib co vascular kab mob;

- ib tug kev tshuaj ntsuam genetic predisposition.

Sawv daws yeej paub yuav ua li cas pab tau cov tshuaj. Qhov no yog ib tug tshwj xeeb ntawm cov protein, hu ua mus cawm cov neeg los ntawm ib tug ntau yam ntawm txawv teb chaws tej khoom xws li kab mob, cov kab mob thiab lwm yam. Tab sis tej zaum lawv pib ua hauj lwm kom zoo thiab nres ib qho tseem ceeb rau lub cev ntsiab, rhuav tseg lawv thiab tiv thaiv kom tej metabolism. Nyob rau hauv cov ntaub ntawv ntawm mas phospholipids tshuaj khi nrog tsis zoo hom (cardiolipin thiab phosphatidylserine). Lawv kuj muaj kev cuam tshuam hauv nruab nrab phospholipid. Qhov no entail? Ib tug ntawm cov loj tshaj teeb meem yog nyob rau hauv yuam cai ntawm platelet week thiab hlwb nyob rau hauv cov hlab ntsha. Nyob rau hauv no hais txog, muaj yog:

- thrombosis;

- ncuav me nyuam tau thiab ntxov ntxov yug;

- fading ntawm lub fetus;

- kab mob;

- lub plawv muaj teeb meem, xws li mob stroke.

APS nrog ib tus nqi ntawm hais txog 5 rau ib 100 nyob rau hauv cev xeeb tub cov poj niam, thiab 3-4 rau ib puas - nyob rau hauv cov neeg laus.

cov tsos mob

Tu siab, tej zaum cov neeg mob yog tsis txawm paub hais tias lawv muaj lub tshuaj nyob rau hauv lub cev es tsis txhob ntawm cov kab mob thiab cov kab mob ua kom puas tseem ceeb rau lub neej ntawm cov tshuaj yeeb dej caw, xws li ib tug phospholipid. Yuav ua li cas tshwm sim, cov neeg paub tsuas yog los ntawm cov analyses. Cov tsos mob qhia tias lub xub ntiag ntawm APS, yog raws li nram no:

- tshwm sim ntawm vascular qauv ntawm lub cev (tshwj xeeb heev nws tshwm nyob rau hauv lub duav thiab ob txhais ceg);

- yuav txo tau ntawm (vim hais tias thrombi tshwm sim nyob rau hauv lub retina);

- muaj protein ntau nyob rau hauv cov zis;

- tawg;

- raum tsis ua hauj;

- abortions thiab cia li laus zuj zus feem ntau tsim fetus;

- ntxov ntxov yug.

diagnostics

Tshuaj rau cardiolipin yog xav tau lub ntsiab feem ntawm cov tshuaj rau phospholipids. Qhov no txhais li cas? Tej tshuaj yog ob peb chav kawm - IgM, IgA thiab IgG. Ib tug me me muaj pes tsawg tus ntawm lawv nyob rau hauv tib neeg lub cev yog ib txwm tam sim no. Cov cai no yog cov nrhiav kom tau nyob rau hauv cov ntshiab :

- IgG - 19 IU / ml;

- IgM - 10 IU / ml;

- IgA - 15 IU / ml.

Nyob rau hauv feem ntau kuaj kev tshawb fawb qhia lub xub ntiag ntawm IgG tshuaj (40-45%) thiab IgA (17-55%). Lub xub ntiag ntawm ntshiab IgM yog tsis tshua muaj heev (5-30%). Tus nqi ntawm cov tshuaj yog significantly txo tom qab kev kho mob nrog APS. Tsis tshua muaj lawv cov nqi kuj cai nyob rau hauv cov neeg mob uas syphilis, lupus, mob caj dab (rheumatoid) thiab Sjogren lub syndrome.

Ib tug ntshav kuaj yuav raug muab coj los tsuas yog nyob rau ib qho kev npliag plab. Tom qab qhov kawg noj mov yuav tsum coj los ntawm 8 rau 12 teev.

Qhov tseem ceeb phospholipids - dab tsi yog nws

Qhov tseem ceeb phospholipids npe hu ua vim hais tias ntawm lawv cov qhov tseem ceeb thiab qhov tseem ceeb rau cell metabolism. Tam sim no muaj cov tshuaj muaj cov tshuaj. Lawv yog siv nyob rau hauv hepatology, Cardiology thiab kev kawm txoj tib neeg lub hlwb. Rau yav tom ntej regenerative tej yam lawv muaj nyob rau hauv lub week ntawm mob hlwb, raws li phospholipids yog 65%. Lawv kuj siv nyob rau hauv:

- kab mob siab;

- intoxication;

- atherosclerosis;

- mob ischemia;

- kab mob ntawm lub digestive ib ntsuj av tau;

- toxicosis;

- kab mob ntawm daim tawv nqaij;

- irradiation.

Muaj pov thawj hais tias muaj ntshav qab zib thiab pab tau cov ntaub ntawv ntawm qhov tseem ceeb phospholipids.

Qhov tshuaj nyob rau hauv tsiav tshuaj thiab cov kev daws cov kev txhaj tshuaj. Thov cov tshuaj nyob rau hauv ua ke nrog nrog lwm yam tshuaj.