"Alendronic acid": cov lus qhia rau kev siv, analogs, xyuas

Uas yuav tsum tau "Alendronic acid"? Lo lus teb rau kev kho mob qhov teeb meem, koj yuav kawm tau los ntawm cov ntaub ntawv ntawm qhov tsab xov xwm. Nyob rau hauv tas li ntawd, peb yuav qhia rau koj txog yuav ua li cas noj cov tshuaj, nyob rau hauv uas tus neeg mob nws tsis yog ntshaw kom siv, thiab yog hais tias lawv muaj kev phiv. Koj kuj yuav kawm txog cov ntawv no nyob rau hauv uas peb xav yog muaj txhais tau tias, yog nws muaj counterparts uas tus neeg mob tham txog nws.

Muaj pes tsawg leeg ntawm cov tshuaj thiab nws tso tawm daim ntawv thiab ntim

"Alendronic acid", yog li ntawd-hu ua tshuaj "Alendronate", yog marketed nyob rau hauv daim ntawv ntawm cov dawb round ntsiav tshuaj. Lub active ingredient ntawm cov tshuaj yog alendronate sodium trihydrate, los yog alendronic acid.

Raws li rau lub ntxiv cov ntsiab, lub active tshuaj muaj raws li nram no: monohydrate, povidone, microcrystalline cellulose, croscarmellose sodium thiab magnesium stearate.

Nyob rau hauv cov khw "Alendronic acid" yuav muaj nyob rau hauv lub hlwv 4 ntsiav tshuaj txhua.

Lub pharmacological thaj chaw ntawm cov tshuaj

Yuav ua li cas yog ib tug "Alendronic acid"? Phau Ntawv Qhia kev npaj hais tias lub cuab tam yog ib qho inhibitor ntawm cov pob txha resorption. Lub mechanism ntawm qhov kev txiav txim ntawm cov tshuaj no yog txuam nrog ib tug txo nyob rau hauv cov kev ua ntawm osteoclasts. Nws progressively tsub kom cov kev ceev (mineral) pob txha ntaub so ntswg, raws li zoo raws li nrog rau nws tsim.

Cov tshuaj ntawm cov tshuaj

Yuav ua li cas absorbed "Alendronic acid"? Cov lus qhia rau kev siv ntawm cov tshuaj no muaj cov lus qhia hais tias thaum muab rau ib qho kev npliag plab (rau 2 teev ua ntej noj tshais), ntawm ib ntau npaum ntawm 70 mg bioavailability ntawm lub active caij nyob rau hauv lub fairer poj niam txiv yog hais txog 0,65%, thiab muaj zog hauv pem teb - txog 0.6%.

Yog hais tias koj noj tshuaj rau ib nrab ib teev los yog ib teev ua ntej ib pluas noj, nws ho txo lub bioavailability (mus txog 0,45% thiab 0.4%, ntsig txog).

Txais ntawm cov tshuaj tsis pub dhau 2 xuab moos tom qab ib tug noj mov tsis cuam tshuam rau bioavailability. Txawm li cas los, tom qab noj tau kas fes thiab txiv kab ntxwv kua txiv txo bioavailability los ntawm kwv yees li 60%.

Thwj toob ntawm tus active ingredient ntawm cov tshuaj noj ntshav cov nqaijrog yog kwv yees li 78%.

Tom qab tau txais cov thawj medicament yog faib nyob rau hauv nqaij mos mos, cov pob txha thiab ces, nyob qhov twg, nyob rau hauv qhov tseeb, yog nws fixation, ob lub raum thiab lub remnants.

Lub concentration ntawm kev siv yeeb tshuaj nyob rau hauv cov ntshav txhais tau tias tom qab tau txais ib tug kho koob tshuaj nram qab no yog cov kev ntsuas kev txwv (tsawg tshaj li 5 ng / ml).

Lub medicament yog biotransformation. Nws yog tas los rau ntawm lub cev unchanged. Cov kev npaj yog yus muaj los ntawm ib tug sai txo nyob rau hauv cov ntshav concentration, thiab ib tug heev qeeb tso tawm ntawm tus pob txha cov ntaub so ntswg.

Indications rau kev siv ntawm cov ntsiav tshuaj

Tam sim no koj paub tias dab tsi yog ib tug "Alendronic acid". Vim li cas peb yuav tsum tau qhov cuab tam? Raws li daim ntawv cov lus qhia, cov tshuaj muaj cov nram qab indications:

• txha nyob rau hauv lub fairer poj niam txiv nyob rau hauv postmenopausal cov poj niam (raws li ib tug tiv thaiv ntawm cov pob txha lov, xws li tus txha nqaj thiab lub duav);
• txha nyob rau hauv lub muaj zog nrog txiv neej pw;
• Txha, uas yog tshwm sim los ntawm lub caij nyoog siv glucocorticoid agents;
• Paget tus kab mob.

"Alendronic acid": contraindications rau kev siv ntawm

Thaum peb xav tias yuav cov tshuaj yuav siv tsis tau? Cov lus qhia rau kev siv ntawm cov tshuaj hais tias cov tshuaj no muaj cov nram qab contraindications:

• hypocalcemia;
• Nce neeg mob medicament rhiab heev rau tshuaj;
• lub cev tsis muaj tus neeg mob yog nyob rau hauv ib tug upright txoj hauj lwm (zaum ncaj los yog sawv) rau ib nrab ib teev;
• mob loj heev mob nyob rau hauv cov mineral metabolism;
• mob loj heev raum tsis ua hauj lwm;
• hypoparathyroidism hnyav;
• esophageal stricture los yog achalasia li zoo li lwm yam kev mob uas ua rau txhaws ntawm cov hlab pas zaub mov;
• glucose-galactose malabsorption, lactase tsis muaj peev xwm los yog lactose intolerance ;
• lactation;
• Calcium malabsorption;
• cev xeeb tub;
• cov me nyuam lub hnub nyoog.

Ceev faj kev tshuaj

Nyob rau hauv tej rooj plaub, "Alendronic acid" yog muab nrog ceev faj? Nyob rau hauv nruj kho mob saib xyuas yuav tsum tau hais tias qeb ntawm cov neeg mob, uas yog tej sib txawv nyob rau hauv cov hnyuv (xws li, xws ailments li esophagitis, dysphagia, duodenitis, gastritis, peptic rwj kab mob 12 duodenal rwj thiab lub plab). Nyob rau hauv tas li ntawd, cov tshuaj yuav tsum tau nrog huab ceev faj nyob rau hauv cov neeg mob uas muaj ib tug tsis muaj peev xwm ntawm vitamin D.

"Alendronic acid": cov lus qhia rau kev siv ntawm cov tshuaj

Medicament "Alendronate" yuav tsum tsuas yog noj ntawm ncauj nyob rau hauv ib tug npaum li ntawm 1 ntsiav tshuaj. Thaum cov tshuaj no yog tsis pom zoo kom zom, los yog yaj. Nws nqa mus yoo mov rau 2 teev ua ntej noj tshais (yam tsawg kawg ib nrab ib teev ua ntej lub thawj koob tshuaj ntawm cov zaub mov, dej, los yog lwm yam kev kho mob pab kiag li lawm).

Cov tshuaj yuav tsum haus dej haus dej ntshiab xwb. Qhov no yog vim lub fact tias lwm yam dej (xws li, ntxhia dej, tshuaj yej, kas fes, txiv kab ntxwv kua txiv) markedly txo qhov haum ntawm lub active tshuaj.

Cov pom zoo ntau npaum ntawm lub medicament yog 1 ntsiav tshuaj (los yog 10 mg) ib hnub twg ib zaug hauv. Nyob rau hauv tej rooj plaub, cov kws kho mob lwm koob tshuaj muab rau ib tug neeg mob, uas yog raws li nram no: 1 ntsiav tshuaj (los yog 70 mg), 1 lub sij hawm rau ib lub lim tiam.

Rau cov kev kho mob ntawm kab mob nyob rau hauv cov txiv neej thiab cov poj niam (nyob rau hauv postmenopausal cov poj niam), raws li zoo raws li txha, uas yog tshwm sim los ntawm heev siv cov glucocorticoid agents, cov tshuaj yog npaum li cas los 10 mg txhua hnub los sis 70 mg ib zaug ib lub lim tiam.

Nrog rau qhov no kev mob nkees li Paget tus kab mob, xam tau tias yog los ntawm peb cov tshuaj muab nyob rau hauv ib tug ntau npaum ntawm 40 mg ib hnub twg. Lub caij ntawm txoj kev kho yog 6 lub hlis.

Yog hais tias koj ntawd tsis yog kev npaj siab hom 1 rau ib lub lim tiam, cov ntsiav tshuaj yuav tsum tau noj nyob rau hauv thaum sawv ntxov hnub tom ntej. Nws yog txwv tsis pub siv cov tshuaj nyob rau hauv tus nqi ntawm ob ntsiav tshuaj ib hnub ib zaug.

Overdose ntawm yeeb tshuaj

Yuav ua li cas tshwm sim yog hais tias tus neeg mob yuav uncontrollably coj xws li "Alendronic acid"? Npaj ntawm no hom muaj cov tsos mob ntawm ib qho kev overdose raws li hypophosphatemia, kub siab, hypocalcemia, erosive thiab ulcerative txhab ntawm tus mob huam, esophagitis, raws plab.

Nyob rau hauv cov ntaub ntawv ntawm tus neeg mob uas nthuav lub txim yuav tsum tau muab tag nrho cov mis nyuj los yog poov hlau-muaj antacids. Nws yog tsim nyog rau cov losis tswvyim dabtsi ntawm cov tshuaj. Nyob rau hauv view ntawm lub ntau dua uas tsim esophageal mucosa voos yog tsis pom zoo kom ntxias ntuav. Nyob rau hauv cov ntaub ntawv ntawm overdose tus neeg mob yuav tsum tau nyob rau hauv ib tug upright txoj hauj lwm.

Phiv los sawv tom qab tau txais medicament

Yuav ua "Alendronic acid" tsis zoo tshwm sim? Xyuas ntawm cov neeg mob thiab cov kws kho mob hais tias cov tshuaj muaj ib tug kuj loj tus naj npawb ntawm kev phiv. Yuav ua li cas raws nraim, peb saib ib tug me ntsis ntxiv.

• Digestive system: esophagitis, raws plab, dysphagia, dyspepsia, mob plab, tsam plab, quav tawv, thiab kub siab. Heev tsis tshua tom qab noj nyob rau hauv cov neeg mob muaj ntuav, melena, xeev siab, esophageal stricture, gastritis, esophageal rwj, rwj lub caj pas thiab lub qhov ncauj kab noj hniav txheej week, esophageal rwj perforation nrog lub advent ntawm los ntshav.
• Lub paj hlwb: mob taub hau.
• Licas: mob nyob rau hauv cov nqaij, cov pob txha thiab pob qij txha.
• Kabmob uas tsis pom kev: scleritis thiab uveitis.
• Kev tsis haum tshuaj: edema angioedema, tawm pob, Stevens-Johnson syndrome thiab lom epidermal necrolysis (nyob rau hauv uas tsis tshua muaj neeg mob).
• Lwm yam kev phiv: erythema, tawm pob, photodermatosis, khaus thiab symptomatic hypocalcemia. Tseem muaj mob ntawm osteonecrosis ntawm lub qis thiab sab sauv lub puab tsaig nyob rau hauv cov neeg mob uas mob cancer uas yauv anticancer txoj kev kho uas yuav siv cov bisphosphonates. Yog li, qhov tshwm sim ntawm osteonecrosis muaj tej yam xws li: cov kws khomob, cancer, kev kho mob nrog corticosteroids, tawg txoj kev kho, cov neeg pluag qhov ncauj, lub zos kab mob los yog mob, xws li osteomyelitis.
• Kuaj kev ntsuam xyuas: nraum thiab me ntsis txo nyob rau hauv lub concentration ntawm calcium thiab phosphate.

Peb tsis tau hais tias tus raug cov tsos mob thaum pib ntawm yeeb tshuaj kho yog cov nram no: malaise, myalgia, thiab kub ib ce.

Sis nrog lwm yam tshuaj

Ua ke nrog rau tej tshuaj rau cov neeg mob yeej tsis muab "Alendronic acid", nws txhais?

Raws li cov kev qhia ntawv, nws tsis yog haum rau lub simultaneous txais tos ntawm lub cuab tam nrog tshuaj uas muaj calcium nyob rau hauv cov qauv thiab antacids (vim ib tug ua tau tsawg dua qub haum ntawm lub active tshuaj tshuaj).

Lub caij nyoog nruab nrab thawj coj ntawm cov tshuaj "Alendronate" thiab siv ntawm lwm cov tshuaj yuav tsum tau tsis tsawg tshaj li ib nrab ib teev.

Nonsteroidal agents, raws li zoo raws li acetylsalicylic acid yuav ho ua rau kom cov kev phiv los ntawm cov tshuaj nyob rau hauv lub mob huam kabmob.

Ua ke txais tos "alendronate" (tab sis tsis ob leeg) nrog cov tshuaj no yog tsis nrog los ntawm ib tug kev hloov ntawm lawv ua thiab txoj kev loj hlob ntawm kev phiv.

Cov kev txais tos ntawm xws li ib tug yeeb tshuaj, raws li ib tug "prednisolone", yog peb tsis koom nrog tseem ceeb kev hloov nyob rau hauv bioavailability acid.

Tshwj xeeb cov lus qhia txog kev txais ib tug kho mob ntaus ntawv

Yuav ua li cas koj yuav tsum paub ua ntej koj pib tau txais ib lub cuab tam xws li "Alendronic acid"? Analogs, thiab nws suav hais tias cov tshuaj yuav adversely muaj feem xyuam rau txoj hnyuv kabmob. Yog li ntawd, kom tsis txhob muaj lub irritant nyhuv ntawm cov tshuaj yog pom zoo kom noj nyob rau hauv thaum sawv ntxov nyob rau ib npliag plab ib khob ntawm cov dej.

Tom qab tau txais cov tshuaj uas tsim nyog rau ib nrab ib teev nyob rau hauv ib tug upright txoj hauj lwm. Siv cov kab rov tav txoj hauj lwm los yog thaum mus pw tsub kom kev pheej hmoo ntawm xws deflection li esophagitis.

Tus neeg mob yuav tsum tau paub txog cov kev discontinuation ntawm cov tshuaj thaum kub siab tshwm sim, cov tsos mob nyob rau hauv lub hauv siab thiab nqos, raws li zoo raws li cov kev loj hlob ntawm dysphagia.

Yog hais tias hypocalcemia yuav tsum ua nws cov kev kho ua ntej pib ntawm txoj kev kho. Nws kuj pom zoo kom tshem tawm cuam tshuam ntawm mineral metabolism uas ua rau qhov no txawv.

Thaum lub sij hawm siv bisphosphonates rau tus neeg mob yuav tsum tau xyuas kom meej qhov tsawg ntawm cov txaus cov nqi ntawm cov vitamin D thiab calcium.

Thaum lub sij hawm txoj kev kho vim hais tias ntawm lub zoo ntxim rau cov acid ntawm cov pob txha ntxhia ceev nyob rau hauv ib tug neeg mob tej zaum yuav muaj ib tug me ntsis txo nyob rau hauv lub concentration ntawm ntsev thiab calcium nyob rau hauv cov ntshav.

Ua ntej rau kev kho mob nrog bisphosphonates nyob rau hauv cov neeg mob uas concomitant muaj tej yam (muaj mob cancer niaj kws khomob, tawg txoj kev kho, lwm yam). Nco ntsoov kom dhau cov kev kho hniav xeem.

Nqe thiab analogues ntawm cov tshuaj

Tam sim no koj paub yuav ua li cas cov tshuaj no yuav tsum tau coj raws li "Alendronic acid". Yuav ua li cas li no tshuaj kho los ntawm tus kws kho mob, peb kuj pom. Txawm li cas los, feem ntau ntawm cov neeg mob uas tau muab tshuaj no, yeej ib txwm txhawj xeeb txog tib lo lus nug: yuav ua li cas npaum li cas yog nws nqi?

Niaj hnub no "Alendronic acid" yuav raug muas 350 rubles (4 ntsiav tshuaj). Muab lub dosing lub sij hawm (ib zaug ib lub lim tiam), tus nqi yog tsis heev.

Yog hais tias ua ntej peb cov tshuaj tsis haum rau koj li cas los xij, nws yuav tsum tau hloov los ntawm sib npaug. Cov no muaj xws tshuaj xws li "Tevanat", "Ostalon", "Alendronate", "Strongos", "Alendrokern", "Ostealen", "Lindron", "Alental", "Foroza", "Osterepar ',' FOSAMAX "thiab thiaj on.

Xyuas ntawm cov neeg mob thiab cov kws kho mob txog cov tshuaj

Yuav ua li cas cov neeg mob thiab cov kws kho mob hais txog lub tsev no raws li "Alendronic acid"? Raws li lawv cov lus teb, cov tshuaj copes nrog neeg ua hauj lwm. Nws yog zoo yuav ntxiv zog rau cov pob txha ntaub so ntswg, hlub txha thiab Paget tus kab mob.

Txawm li cas los, nws yog tsis yooj yim sua tsis kom nco ntsoov qhov tseeb hais tias cov tshuaj no muaj ib tug kuj loj tus naj npawb ntawm kev phiv. Yog li ntawd, cov tshuaj yuav tsum tau noj tsuas yog nyob rau lub sij hawm ntawm cov kws txawj. Cov yav tas yuav tsum nco ntsoov qhia rau tus neeg mob txog lub contraindications.

Qhov loj tshaj plaws pes tsawg tus ntawm tsis zoo xyuas nyob rau hauv qhov chaw nyob "alendronic acid" los ntawm cov neeg mob uas muaj teeb meem nrog lub digestive ib ntsuj av. Qhov no yog vim lub fact tias cov tshuaj no tej zaum yuav cuam tshuam rau lub plab, txoj hlab nqos mov thiab cov hnyuv.